Edward Hsiao, MD, PhD

Associate Professor
Medicine
+1 415 476-9732

Academic:
My research is driven by a desire to understand how major hormonal and regulatory pathways determine the specification, differentiation, and morphogenesis of mesenchymal tissues such as bone, cartilage, muscle, and fat. Mis-regulation of these pathways leads to significant medical diseases, including the inappropriate formation of mineralized tissues in atherosclerosis, heterotopic ossification, and cancer.

My research focuses on understanding how these regulatory signals control normal and pathologic tissue formation as a way to identifying new therapeutic avenues for treating human diseases. Our laboratory takes a comprehensive approach to understanding hormone signaling in human diseases using synthetic biology approaches, mouse models, and human stem cell models.

By combining multiple approaches with state-of-the art methods, our laboratory is working to develop a broader understanding of the biology underlying skeletal development, devise novel therapeutic approaches for treating human skeletal disorders and bone injuries, and examine how hormone signals affect important tissues such as fat, muscle, bone, cartilage, and blood vessels.

Clinical:
General Endocrinology with an interest in inherited skeletal diseases, including fibrous dysplasia of the bone (FD), McCune-Albright syndrome (MAS), and fibrodysplasia ossificans progressiva (FOP).

Interests: Metabolic bone diseases, human genetics, skeletal dysplasias, human iPS cells, skeletogenesis

Publications: 

MMP-9 deficiency confers resilience in Fibrodysplasia Ossificans Progressiva in a man and mice.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Lounev V, Groppe JC, Brewer N, Wentworth KL, Smith V, Xu M, Schomburg L, Bhargava P, Al Mukaddam M, Hsiao EC, Shore EM, Pignolo RJ, Kaplan FS

Wnt Pathway Inhibition with the Porcupine Inhibitor LGK974 Decreases Trabecular Bone but not Fibrosis in a Murine Model with Fibrotic Bone.

JBMR plus

Hsuan Lung, Kelly L Wentworth, Tania Moody, Ariane Zamarioli, Apsara Ram, Gauri Ganesh, Misun Kang, Sunita Ho, Edward C Hsiao

Overall survival with [177Lu]Lu-PSMA-617 versus cabazitaxel in metastatic castration-resistant prostate cancer (TheraP): secondary outcomes of a randomised, open-label, phase 2 trial.

The Lancet. Oncology

Hofman MS, Emmett L, Sandhu S, Iravani A, Buteau JP, Joshua AM, Goh JC, Pattison DA, Tan TH, Kirkwood ID, Ng S, Francis RJ, Gedye C, Rutherford NK, Weickhardt A, Scott AM, Lee ST, Kwan EM, Azad AA, Ramdave S, Redfern AD, Macdonald W, Guminski A, Hsiao E, Chua W, Lin P, Zhang AY, Stockler MR, Williams SG, Martin AJ, Davis ID, TheraP Trial Investigators and the Australian and New Zealand Urogenital and Prostate Cancer Trials

Study methodology and insights from the palovarotene clinical development program in fibrodysplasia ossificans progressiva.

BMC medical research methodology

Pignolo RJ, Al Mukaddam M, Baujat G, Brown MA, De Cunto C, Hsiao EC, Keen R, Le Quan Sang KH, Grogan DR, Marino R, Strahs AR, Kaplan FS

Frontal bone loss following coronal brow lift: A mimicker of head variant linear morphea.

JAAD case reports

Kazmi M, Zhang WR, Hsiao E, Gross A, Grouse K, Link TM, Tetzlaff M, Theodosopoulos P, Haemel A

Modeling and therapeutic targeting of inflammation-induced hepatic insulin resistance using human iPSC-derived hepatocytes and macrophages.

Nature communications

Groeger M, Matsuo K, Heidary Arash E, Pereira A, Le Guillou D, Pino C, Telles-Silva KA, Maher JJ, Hsiao EC, Willenbring H

EML4::ALK fusions in complex lymphatic malformations.

Pediatric blood & cancer

Apsel Winger B, Devine WP, Hsiao EC, Zapala M, Van Ziffle J, Gupta N, Frieden IJ, Shimano KA

A Case of Hypercalcemia from PTHrP-Producing Fibromyxoid Sarcoma Responsive to Glucocorticoid Therapy.

Calcified tissue international

Niu I, Hsiao EC, Wustrack R, Wysolmerski JJ, Dann P, Masharani U

Improving care pathways for people living with rare bone diseases (RBDs): outcomes from the first RBD Summit.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

Chandran M, Alves I, Carpenter T, Davis M, Hsiao EC, Petryk A, Semler JO, Sleiman M

CO32 Heterotopic Ossification in Palovarotene-Treated and Untreated Individuals with Fibrodysplasia Ossificans Progressiva: Matched and Weighted Analyses.

Value in Health

M. Al Mukaddam, G. Baujat, A.M. Cheung, C. De Cunto, E.C. Hsiao, R. Keen, J. Marden, J. Signorovitch, E. Boing, R. Marino, A. Strahs, R.J. Pignolo

Most Fractures Treated Nonoperatively in Individuals With Fibrodysplasia Ossificans Progressiva Heal With a Paucity of Flareups, Heterotopic Ossification, and Loss of Mobility.

Clinical orthopaedics and related research

Lindborg CM, Al Mukaddam M, Baujat G, Cho TJ, De Cunto CL, Delai PLR, Eekhoff EMW, Haga N, Hsiao EC, Morhart R, de Ruiter R, Scott C, Seemann P, Szczepanek M, Tabarkiewicz J, Pignolo RJ, Kaplan FS

Human iPSC-Derived Proinflammatory Macrophages cause Insulin Resistance in an Isogenic White Adipose Tissue Microphysiological System.

Small (Weinheim an der Bergstrasse, Germany)

Qi L, Matsuo K, Pereira A, Lee YT, Zhong F, He Y, Zushin PH, Gr?ger M, Sharma A, Willenbring H, Hsiao EC, Stahl A

Reduction of New Heterotopic Ossification (HO) in the Open-Label, Phase 3 MOVE Trial of Palovarotene for Fibrodysplasia Ossificans Progressiva (FOP).

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Pignolo RJ, Hsiao EC, Al Mukaddam M, Baujat G, Berglund SK, Brown MA, Cheung AM, De Cunto C, Delai P, Haga N, Kannu P, Keen R, Le Quan Sang KH, Mancilla EE, Marino R, Strahs A, Kaplan FS

The effects of palovarotene in patients with fibrodysplasia ossificans progressiva: a plain language summary.

Future Rare Diseases

Robert J Pignolo, Edward C Hsiao, Mona Al Mukaddam, Geneviève Baujat, Staffan K Berglund, Matthew A Brown, Angela M Cheung, Carmen De Cunto, Patricia Delai, Nobuhiko Haga, Peter Kannu, Richard Keen, Kim-Hanh Le Quan Sang, Edna E Mancilla, Rose Marino, Andrew Strahs, Frederick S Kaplan

Functional Testing of Bone Morphogenetic Protein (BMP) Pathway Variants Identified on Whole-Exome Sequencing in a Patient with Delayed-Onset Fibrodysplasia Ossificans Progressiva (FOP) Using ACVR1R206H -Specific Human Cellular and Zebrafish Models.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Wentworth KL, Lalonde RL, Groppe JC, Brewer N, Moody T, Hansberry S, Taylor KE, Shore EM, Kaplan FS, Pignolo RJ, Yelick PC, Hsiao EC

PSAT208 A Case of Hypercalcemia From PTHrP-Producing Fibromyxoid Sarcoma Responsive to Glucocorticoid Therapy.

Journal of the Endocrine Society

Isabella Niu, Edward Hsiao, Rosanna Wustrack, John Wysolmerski, Pamela Dann, Umesh Masharani

Suppression of heterotopic ossification in fibrodysplasia ossificans progressiva using AAV gene delivery.

Nature communications

Yang YS, Kim JM, Xie J, Chaugule S, Lin C, Ma H, Hsiao E, Hong J, Chun H, Shore EM, Kaplan FS, Gao G, Shim JH

The natural history of fibrodysplasia ossificans progressiva: A prospective, global 36-month study.

Genetics in medicine : official journal of the American College of Medical Genetics

Pignolo RJ, Baujat G, Brown MA, De Cunto C, Hsiao EC, Keen R, Al Mukaddam M, Le Quan Sang KH, Wilson A, Marino R, Strahs A, Kaplan FS

Identification of Risk Factors in the Development of Heterotopic Ossification after Primary Total Hip Arthroplasty.

The Journal of clinical endocrinology and metabolism

Singh S, Morshed S, Motamedi D, Kidane J, Paul A, Hsiao EC, Wentworth KL

Palovarotene for Fibrodysplasia Ossificans Progressiva (FOP): Results of a Randomized, Placebo-Controlled, Double-Blind Phase 2 Trial.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Pignolo RJ, Baujat G, Hsiao EC, Keen R, Wilson A, Packman J, Strahs AL, Grogan DR, Kaplan FS

Gene therapy for Fibrodysplasia Ossificans Progressiva (FOP): feasibility and obstacles.

Human gene therapy

Eekhoff EMW, de Ruiter RD, Smilde BJ, Schoenmaker T, Vries TJ, Netelenbos C, Hsiao EC, Scott C, Haga N, Grunwald Z, De Cunto CL, Di Rocco M, Delai P, Diecidue R, Madhuri V, Cho TJ, Morhart R, Friedman C, Zasloff M, Pals G, Shim JH, Gao G, Kaplan F, Pignolo RJ, Micha D

An ACVR1 activating mutation causes neuropathic pain and sensory neuron hyperexcitability in humans.

Pain

Yu X, Ton AN, Niu Z, Morales BM, Chen J, Braz J, Lai MH, Barruet E, Liu H, Cheung K, Ali S, Chan T, Bigay K, Ho J, Nikolli I, Hansberry S, Wentworth K, Kriegstein A, Basbaum A, Hsiao EC

Social and clinical impact of COVID-19 on patients with fibrodysplasia ossificans progressiva.

Orphanet journal of rare diseases

Kou S, Kile S, Kambampati SS, Brady EC, Wallace H, De Sousa CM, Cheung K, Dickey L, Wentworth KL, Hsiao EC

The Clinical Significance of Small Vessel Vasculitis on Temporal Artery Biopsies.

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society

Quigley J, Sammel AM, Laurent R, Brewer J, Hsiao E, Schembri G, Fraser CL

A single center evaluation of applicant experiences in virtual interviews across eight internal medicine subspecialty fellowship programs.

Medical education online

Huppert LA, Hsu G, Elnachef N, Flint L, Frank JA, Gensler LS, Hsiao EC, Khanna RR, Qasim A, Schwartz BS, Widera E, Zapata C, Babik JM

Fibrodysplasia Ossificans Progressiva: What Have We Achieved and Where Are We Now? Follow-up to the 2015 Lorentz Workshop.

Frontiers in endocrinology

de Ruiter RD, Smilde BJ, Pals G, Bravenboer N, Knaus P, Schoenmaker T, Botman E, Sánchez-Duffhues G, Pacifici M, Pignolo RJ, Shore EM, van Egmond M, Van Oosterwyck H, Kaplan FS, Hsiao EC, Yu PB, Bocciardi R, De Cunto CL, Longo Ribeiro Delai P, de Vries TJ, Hilderbrandt S, Jaspers RT, Keen R, Koolwijk P, Morhart R, Netelenbos JC, Rustemeyer T, Scott C, Stockklausner C, Ten Dijke P, Triffit J, Ventura F, Ravazzolo R, Micha D, Eekhoff EMW

Modeling the ACVR1R206H mutation in human skeletal muscle stem cells.

eLife

Barruet E, Garcia SM, Wu J, Morales BM, Tamaki S, Moody T, Pomerantz JH, Hsiao EC

Social and Clinical Impact of COVID-19 on Patients with Fibrodysplasia Ossificans Progressiva.

Research square

Kou S, Kile S, Kambampati SS, Brady EC, Wallace H, De Sousa CM, Cheung K, Dickey L, Wentworth KL, Hsiao E

Prevalence of fibrodysplasia ossificans progressiva (FOP) in the United States: estimate from three treatment centers and a patient organization.

Orphanet journal of rare diseases

Pignolo RJ, Hsiao EC, Baujat G, Lapidus D, Sherman A, Kaplan FS

Whole-body Computed Tomography Versus Dual Energy X-ray Absorptiometry for Assessing Heterotopic Ossification in Fibrodysplasia Ossificans Progressiva.

Calcified tissue international

Warner SE, Kaplan FS, Pignolo RJ, Smith SE, Hsiao EC, De Cunto C, Di Rocco M, Harnett K, Grogan D, Genant HK

ACVR1R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophages.

Bone

Matsuo K, Lepinski A, Chavez RD, Barruet E, Pereira A, Moody TA, Ton AN, Sharma A, Hellman J, Tomoda K, Nakamura MC, Hsiao EC

Re-defining the role of surgery in the management of patients with oligometastatic stage IV melanoma in the era of effective systemic therapies.

European journal of cancer (Oxford, England : 1990)

Ch'ng S, Uyulmaz S, Carlino MS, Pennington TE, Shannon KF, Rtshiladze M, Stretch JR, Nieweg OE, Varey AHR, Hsiao E, Kapoor R, Pires da Silva I, Lo SN, Spillane AJ, Scolyer RA, Long GV, Hong AM, Saw RPM, Thompson JF, Menzies AM

Off-on-off-on use of imatinib in three children with fibrodysplasia ossificans progressiva.

Bone

Kaplan FS, Teachey DT, Andolina JR, Siegel DM, Mancilla EE, Hsiao EC, Al Mukaddam M, Rocke DM, Pignolo RJ

Global Wnt Inhibition With a Porcupine Inhibitor Decreases Established Trabecular Bone in a Mouse Model of Fibrous Dysplasia.

Journal of the Endocrine Society

Hsuan Lung, Tania Moody, Kelly Wentworth, Misun Kang, Sunita Ho, Edward Hsiao

[177Lu]Lu-PSMA-617 versus cabazitaxel in patients with metastatic castration-resistant prostate cancer (TheraP): a randomised, open-label, phase 2 trial.

Lancet (London, England)

Hofman MS, Emmett L, Sandhu S, Iravani A, Joshua AM, Goh JC, Pattison DA, Tan TH, Kirkwood ID, Ng S, Francis RJ, Gedye C, Rutherford NK, Weickhardt A, Scott AM, Lee ST, Kwan EM, Azad AA, Ramdave S, Redfern AD, Macdonald W, Guminski A, Hsiao E, Chua W, Lin P, Zhang AY, McJannett MM, Stockler MR, Violet JA, Williams SG, Martin AJ, Davis ID, TheraP Trial Investigators and the Australian and New Zealand Urogenital and Prostate Cancer Trials

A Global Natural History Study of Fibrodysplasia Ossificans Progressiva (FOP): 12-Month Outcomes.

Osteologie/Osteology

M Al Mukaddam, C Stockklausner, RJ Pignolo, G Baujat, MA Brown, C De Cunto, M Di Rocco, EC Hsiao, R Keen, K-H Le Quan Sang, A Strahs, R Marino, FS Kaplan

Longitudinal and Flare-Up-Specific Biomarkers in Fibrodysplasia Ossificans Progressiva (FOP): Data from a Global Natural History Study.

Osteologie/Osteology

RJ Pignolo, JO Semler, M Al Mukaddam, G Baujat, C De Cunto, EC Hsiao, R Keen, K Harnett, R Marino, FS Kaplan

Medications Used by Individuals with Fibrodysplasia Ossificans Progressiva (FOP): Data from a Global Natural History Study.

Osteologie/Osteology

R Keen, C Stockklausner, M Al Mukaddam, G Baujat, C De Cunto, EC Hsiao, RJ Pignolo, K Harnett, R Marino, FS Kaplan

Use of Assistive Devices and Adaptations by Individuals with Fibrodysplasia Ossificans Progressiva (FOP): Data from a Global Natural History Study.

Osteologie/Osteology

EC Hsiao, JO Semler, M Al Mukaddam, G Baujat, C De Cunto, R Keen, RJ Pignolo, K Harnett, R Marino, FS Kaplan

Virtual Interviews at Graduate Medical Education Training Programs: Determining Evidence-Based Best Practices.

Academic medicine : journal of the Association of American Medical Colleges

Huppert LA, Hsiao EC, Cho KC, Marquez C, Chaudhry RI, Frank J, Goglin SE, Hsu G, Kathpalia P, Khanna R, Kompala T, Rao MN, Bower BA, Trafas V, Santhosh L, Schwartz BS, Babik JM

A natural history study of fibrodysplasia ossificans progressiva (FOP): 12-month outcome results.

Bone reports

Robert J. Pignolo, Geneviève Baujat, Matthew A. Brown, Carmen De Cunto, Maja Di Rocco, Edward C. Hsiao, Richard Keen, Mona Al Mukaddam, Kim Hanh Le Quan Sang, Andrew Strahs, Rose Marino, Frederick S. Kaplan

Measuring outcomes in ultra-rare bone diseases: Methodology of the palovarotene fibrodysplasia ossificans progressiva clinical development programme.

Bone reports

Robert J. Pignolo, Geneviève Baujat, Matthew A. Brown, Carmen De Cunto, Maja Di Rocco, Edward C. Hsiao, Richard Keen, Mona Al Mukaddam, Andrew Strahs, Donna R. Grogan, Rose Marino, Frederick S. Kaplan

A global natural history study of Fibrodysplasia Ossificans Progressiva (FOP): 12-month outcomes.

Endocrine Abstracts

Mona Al Mukaddam, Robert J. Pignolo, Geneviève Baujat, Matthew A Brown, Cunto Carmen De, Rocco Maja Di, Edward C. Hsiao, Richard Keen, Quan Sang Kim-Hanh Le, Andrew Strahs, Rose Marino, Frederick S Kaplan

Patients with ACVR1R206H mutations have an increased prevalence of cardiac conduction abnormalities on electrocardiogram in a natural history study of Fibrodysplasia Ossificans Progressiva.

Orphanet journal of rare diseases

Kou S, De Cunto C, Baujat G, Wentworth KL, Grogan DR, Brown MA, Di Rocco M, Keen R, Al Mukaddam M, le Quan Sang KH, Masharani U, Kaplan FS, Pignolo RJ, Hsiao EC

MON-348 Surgical Management of Bilateral Hip Fracture in a Patient with Fibrodysplasia Ossificans Progressiva Treated with Palovarotene.

Journal of the Endocrine Society

Sukhmani Singh, Joseph Kidane, Kelly Lee Wentworth, Daria Motamedi, Saam Morshed, Edward Chiaming Hsiao

MON-710 ACVR1 Activation in Primary and iPS-Derived Human Skeletal Muscle Stem Cells Impairs Myogenic Transcriptional Signature and Function.

Journal of the Endocrine Society

Emilie Barruet, Steven Garcia, Stanley Tamaki, Blanca M Morales, Jake Wu, Tania Moody, Jason H Pomerantz, Edward Chiaming Hsiao

OR29-05 A Natural History Study of Fibrodysplasia Ossificans Progressiva (FOP): 12-Month Outcomes.

Journal of the Endocrine Society

Mona Al Mukaddam, Robert J Pignolo, Geneviève Baujat, Matthew A Brown, Carmen De Cunto, Maja Di Rocco, Edward C Hsiao, Richard W Keen, Kim-Hanh Le Quan Sang, Andrew Strahs, Rose Marino, Frederick S Kaplan

SUN-344 Patients with Fibrodysplasia Ossificans Progressiva Have an Increased Prevalence of Cardiac Conduction Abnormalities.

Journal of the Endocrine Society

Samuel Kou, Carmen DeCunto, Geneviève Baujat, Kelly Lee Wentworth, Donna Grogan, Matthew A Brown, Maja D Rocco, Richard Keen, Mona Al Mukaddam, Frederick S Kaplan, Robert J Pignolo, Edward Chiaming Hsiao

SUN-368 Wnt Inhibition Decreases Trabecular Bone in a Mouse Model of Fibrous Dysplasia.

Journal of the Endocrine Society

Hsuan Lung, Kelly Wentworth, Tania Moody, Misun Kang, Sunita Ho, Edward Hsiao

Surgical management of bilateral hip fractures in a patient with fibrodysplasia ossificans progressiva treated with the RAR-? agonist palovarotene: a case report.

BMC musculoskeletal disorders

Singh S, Kidane J, Wentworth KL, Motamedi D, Morshed S, Schober AE, Hsiao EC

Self-reported baseline phenotypes from the International Fibrodysplasia Ossificans Progressiva (FOP) Association Global Registry.

Bone

Pignolo RJ, Cheung K, Kile S, Fitzpatrick MA, De Cunto C, Al Mukaddam M, Hsiao EC, Baujat G, Delai P, Eekhoff EMW, Di Rocco M, Grunwald Z, Haga N, Keen R, Levi B, Morhart R, Scott C, Sherman A, Zhang K, Kaplan FS

Advances in Models of Fibrous Dysplasia/McCune-Albright Syndrome.

Frontiers in endocrinology

Lung H, Hsiao EC, Wentworth KL

Inflammation in Fibrodysplasia Ossificans Progressiva and Other Forms of Heterotopic Ossification.

Current osteoporosis reports

Matsuo K, Chavez RD, Barruet E, Hsiao EC

Palovarotene inhibits the development of new heterotopic ossification in fibrodysplasia ossificans progressiva (FOP).

Bone Abstracts

Frederick Kaplan, Edward C Hsiao, Genevieve Baujat, Richard Keen, Cunto Carmen De, Rocco Maja Di, Matthew A Brown, Mukaddam Mona M Al, Donna R Grogan, Robert J Pignolo

Correction to: Natural history of fibrodysplasia ossificans progressiva: cross-sectional analysis of annotated baseline phenotypes.

Orphanet journal of rare diseases

Pignolo RJ, Baujat G, Brown MA, De Cunto C, Di Rocco M, Hsiao EC, Keen R, Al Mukaddam M, Sang KLQ, Wilson A, White B, Grogan DR, Kaplan FS

Natural history of fibrodysplasia ossificans progressiva: cross-sectional analysis of annotated baseline phenotypes.

Orphanet journal of rare diseases

Pignolo RJ, Baujat G, Brown MA, De Cunto C, Di Rocco M, Hsiao EC, Keen R, Al Mukaddam M, Sang KLQ, Wilson A, White B, Grogan DR, Kaplan FS

Effect of donor variation on osteogenesis and vasculogenesis in hydrogel cocultures.

Journal of tissue engineering and regenerative medicine

Pennings I, van Dijk LA, van Huuksloot J, Fledderus JO, Schepers K, Braat AK, Hsiao EC, Barruet E, Morales BM, Verhaar MC, Rosenberg AJWP, Gawlitta D

Therapeutic advances for blocking heterotopic ossification in fibrodysplasia ossificans progressiva.

British journal of clinical pharmacology

Wentworth KL, Masharani U, Hsiao EC

NF-?B/MAPK activation underlies ACVR1-mediated inflammation in human heterotopic ossification.

JCI insight

Barruet E, Morales BM, Cain CJ, Ton AN, Wentworth KL, Chan TV, Moody TA, Haks MC, Ottenhoff TH, Hellman J, Nakamura MC, Hsiao EC

Special considerations for clinical trials in fibrodysplasia ossificans progressiva (FOP).

British journal of clinical pharmacology

Hsiao EC, Di Rocco M, Cali A, Zasloff M, Al Mukaddam M, Pignolo RJ, Grunwald Z, Netelenbos C, Keen R, Baujat G, Brown MA, Cho TJ, De Cunto C, Delai P, Haga N, Morhart R, Scott C, Zhang K, Diecidue RJ, Friedman CS, Kaplan FS, Eekhoff EMW

Fibrodysplasia ossificans progressiva: a current review of imaging findings.

Skeletal radiology

Bauer AH, Bonham J, Gutierrez L, Hsiao EC, Motamedi D

Utilizing 18F-fluoroethyltyrosine (FET) positron emission tomography (PET) to define suspected nonenhancing tumor for radiation therapy planning of glioblastoma.

Practical radiation oncology

Hayes AR, Jayamanne D, Hsiao E, Schembri GP, Bailey DL, Roach PJ, Khasraw M, Newey A, Wheeler HR, Back M

Clinical-pathological correlations in three patients with fibrodysplasia ossificans progressiva.

Bone

Wentworth KL, Bigay K, Chan TV, Ho JP, Morales BM, Connor J, Brooks E, Shahriar Salamat M, Sanchez HC, Wool G, Pignolo RJ, Kaplan FS, Hsiao EC

Sirtuin-3 Promotes Adipogenesis, Osteoclastogenesis, and Bone Loss in Aging Male Mice.

Endocrinology

Ho L, Wang L, Roth TM, Pan Y, Verdin EM, Hsiao EC, Nissenson RA

The FOP Connection Registry: Design of an international patient-sponsored registry for Fibrodysplasia Ossificans Progressiva.

Bone

Mantick N, Bachman E, Baujat G, Brown M, Collins O, De Cunto C, Delai P, Eekhoff M, Zum Felde R, Grogan DR, Haga N, Hsiao E, Kantanie S, Kaplan F, Keen R, Milosevic J, Morhart R, Pignolo R, Qian X, di Rocco M, Scott C, Sherman A, Wallace M, Williams N, Zhang K, Bogard B

Early clinical observations on the use of imatinib mesylate in FOP: A report of seven cases.

Bone

Kaplan FS, Andolina JR, Adamson PC, Teachey DT, Finklestein JZ, Ebb DH, Whitehead B, Jacobs B, Siegel DM, Keen R, Hsiao E, Pignolo RJ

Fibrodysplasia ossificans progressiva: baseline characteristics of 101 subjects participating in a global, longitudinal, natural history study.

Bone Abstracts

Frederick S Kaplan, Edward C Hsiao, Genevieve Baujat, Matthew A Brown, Cunto Carmen De, Rocco Maja Di, Richard Keen, Makkadam Mona Al, Donna R Grogan, Robert J Pignolo

International physician survey on management of FOP: a modified Delphi study.

Orphanet journal of rare diseases

Di Rocco M, Baujat G, Bertamino M, Brown M, De Cunto CL, Delai PLR, Eekhoff EMW, Haga N, Hsiao E, Keen R, Morhart R, Pignolo RJ, Kaplan FS

Fluorescent tagged episomals for stoichiometric induced pluripotent stem cell reprogramming.

Stem cell research & therapy

Schmitt CE, Morales BM, Schmitz EMH, Hawkins JS, Lizama CO, Zape JP, Hsiao EC, Zovein AC

Dual Somatostatin Receptor/FDG PET/CT Imaging in Metastatic Neuroendocrine Tumours: Proposal for a Novel Grading Scheme with Prognostic Significance.

Theranostics

Chan DL, Pavlakis N, Schembri GP, Bernard EJ, Hsiao E, Hayes A, Barnes T, Diakos C, Khasraw M, Samra J, Eslick E, Roach PJ, Engel A, Clarke SJ, Bailey DL

EPHRIN-B1 Mosaicism Drives Cell Segregation in Craniofrontonasal Syndrome hiPSC-Derived Neuroepithelial Cells.

Stem cell reports

Niethamer TK, Larson AR, O'Neill AK, Bershteyn M, Hsiao EC, Klein OD, Pomerantz JH, Bush JO

BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence.

Proceedings of the National Academy of Sciences of the United States of America

Hayashi Y, Hsiao EC, Sami S, Lancero M, Schlieve CR, Nguyen T, Yano K, Nagahashi A, Ikeya M, Matsumoto Y, Nishimura K, Fukuda A, Hisatake K, Tomoda K, Asaka I, Toguchida J, Conklin BR, Yamanaka S

Gs/Gi Regulation of Bone Cell Differentiation: Review and Insights from Engineered Receptors.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme

Hsiao EC, Millard SM, Nissenson RA

A Novel T55A Variant of Gs a Associated with Impaired cAMP Production, Bone Fragility, and Osteolysis.

Case reports in endocrinology

Wentworth K, Hsing A, Urrutia A, Zhu Y, Horvai AE, Bastepe M, Hsiao EC

Loss of Iroquois homeobox transcription factors 3 and 5 in osteoblasts disrupts cranial mineralization.

Bone reports

Cain CJ, Gaborit N, Lwin W, Barruet E, Ho S, Bonnard C, Hamamy H, Shboul M, Reversade B, Kayserili H, Bruneau BG, Hsiao EC

Increased Gs Signaling in Osteoblasts Reduces Bone Marrow and Whole-Body Adiposity in Male Mice.

Endocrinology

Cain CJ, Valencia JT, Ho S, Jordan K, Mattingly A, Morales BM, Hsiao EC

Phocine distemper virus: current knowledge and future directions.

Viruses

Duignan PJ, Van Bressem MF, Baker JD, Barbieri M, Colegrove KM, De Guise S, de Swart RL, Di Guardo G, Dobson A, Duprex WP, Early G, Fauquier D, Goldstein T, Goodman SJ, Grenfell B, Groch KR, Gulland F, Hall A, Jensen BA, Lamy K, Matassa K, Mazzariol S, Morris SE, Nielsen O, Rotstein D, Rowles TK, Saliki JT, Siebert U, Waltzek T, Wellehan JF

A Case of Hypercalcemia and Overexpression of CYP27B1 in Skeletal Muscle Lesions in a Patient with HIV Infection After Cosmetic Injections with Polymethylmethacrylate (PMMA) for Wasting.

Calcified tissue international

Hindi SM, Wang Y, Jones KD, Nussbaum JC, Chang Y, Masharani U, Bikle D, Shoback DM, Hsiao EC

Maternal Hypercalcemia Due to Failure of 1,25-Dihydroxyvitamin-D3 Catabolism in a Patient With CYP24A1 Mutations.

The Journal of clinical endocrinology and metabolism

Shah AD, Hsiao EC, O'Donnell B, Salmeen K, Nussbaum R, Krebs M, Baumgartner-Parzer S, Kaufmann M, Jones G, Bikle DD, Wang Y, Mathew AS, Shoback D, Block-Kurbisch I

Loss of Gi G-Protein-Coupled Receptor Signaling in Osteoblasts Accelerates Bone Fracture Healing.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Wang L, Hsiao EC, Lieu S, Scott M, O'Carroll D, Urrutia A, Conklin BR, Colnot C, Nissenson RA

Assessing the osteoblast transcriptome in a model of enhanced bone formation due to constitutive Gs-G protein signaling in osteoblasts.

Experimental cell research

Wattanachanya L, Wang L, Millard SM, Lu WD, O'Carroll D, Hsiao EC, Conklin BR, Nissenson RA

Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory.

Nature neuroscience

Orr AG, Hsiao EC, Wang MM, Ho K, Kim DH, Wang X, Guo W, Kang J, Yu GQ, Adame A, Devidze N, Dubal DB, Masliah E, Conklin BR, Mucke L

Disrupted bone remodeling leads to cochlear overgrowth and hearing loss in a mouse model of fibrous dysplasia.

PloS one

Akil O, Hall-Glenn F, Chang J, Li A, Chang W, Lustig LR, Alliston T, Hsiao EC

Panostotic expansile bone disease with massive jaw tumor formation and a novel mutation in the signal peptide of RANK.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Schafer AL, Mumm S, El-Sayed I, McAlister WH, Horvai AE, Tom AM, Hsiao EC, Schaefer FV, Collins MT, Anderson MS, Whyte MP, Shoback DM

Cell-autonomous correction of ring chromosomes in human induced pluripotent stem cells.

Nature

Bershteyn M, Hayashi Y, Desachy G, Hsiao EC, Sami S, Tsang KM, Weiss LA, Kriegstein AR, Yamanaka S, Wynshaw-Boris A

Induced pluripotent stem cells from patients with human fibrodysplasia ossificans progressiva show increased mineralization and cartilage formation.

Orphanet journal of rare diseases

Matsumoto Y, Hayashi Y, Schlieve CR, Ikeya M, Kim H, Nguyen TD, Sami S, Baba S, Barruet E, Nasu A, Asaka I, Otsuka T, Yamanaka S, Conklin BR, Toguchida J, Hsiao EC

Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche.

Cell stem cell

Schepers K, Pietras EM, Reynaud D, Flach J, Binnewies M, Garg T, Wagers AJ, Hsiao EC, Passegué E

AKAP13 Rho-GEF and PKD-binding domain deficient mice develop normally but have an abnormal response to ß-adrenergic-induced cardiac hypertrophy.

PloS one

Spindler MJ, Burmeister BT, Huang Y, Hsiao EC, Salomonis N, Scott MJ, Srivastava D, Carnegie GK, Conklin BR

Mineral composition is altered by osteoblast expression of an engineered G(s)-coupled receptor.

Calcified tissue international

Kazakia GJ, Speer D, Shanbhag S, Majumdar S, Conklin BR, Nissenson RA, Hsiao EC

Constitutive Gs activation using a single-construct tetracycline-inducible expression system in embryonic stem cells and mice.

Stem cell research & therapy

Hsiao EC, Nguyen TD, Ng JK, Scott MJ, Chang WC, Zahed H, Conklin BR

Gs G protein-coupled receptor signaling in osteoblasts elicits age-dependent effects on bone formation.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Hsiao EC, Boudignon BM, Halloran BP, Nissenson RA, Conklin BR

Ligand-mediated activation of an engineered gs g protein-coupled receptor in osteoblasts increases trabecular bone formation.

Molecular endocrinology (Baltimore, Md.)

Hsiao EC, Millard SM, Louie A, Huang Y, Conklin BR, Nissenson RA

Engineering GPCR signaling pathways with RASSLs.

Nature methods

Conklin BR, Hsiao EC, Claeysen S, Dumuis A, Srinivasan S, Forsayeth JR, Guettier JM, Chang WC, Pei Y, McCarthy KD, Nissenson RA, Wess J, Bockaert J, Roth BL

Marking embryonic stem cells with a 2A self-cleaving peptide: a NKX2-5 emerald GFP BAC reporter.

PloS one

Hsiao EC, Yoshinaga Y, Nguyen TD, Musone SL, Kim JE, Swinton P, Espineda I, Manalac C, deJong PJ, Conklin BR

MicroRNA regulation of cell lineages in mouse and human embryonic stem cells.

Cell stem cell

Ivey KN, Muth A, Arnold J, King FW, Yeh RF, Fish JE, Hsiao EC, Schwartz RJ, Conklin BR, Bernstein HS, Srivastava D

Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass.

Proceedings of the National Academy of Sciences of the United States of America

Hsiao EC, Boudignon BM, Chang WC, Bencsik M, Peng J, Nguyen TD, Manalac C, Halloran BP, Conklin BR, Nissenson RA

Modifying ligand-induced and constitutive signaling of the human 5-HT4 receptor.

PloS one

Chang WC, Ng JK, Nguyen T, Pellissier L, Claeysen S, Hsiao EC, Conklin BR

Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors.

Proceedings of the National Academy of Sciences of the United States of America

Kwon C, Arnold J, Hsiao EC, Taketo MM, Conklin BR, Srivastava D

A Series of RASSLs Activated by a Single Agonist.

The FASEB Journal

Peter Chang, Edward Hsiao, Alex C Zambon, Bruce R Conklin

Growth differentiation factor-15: induction in liver injury through p53 and tumor necrosis factor-independent mechanisms.

The Journal of surgical research

Zimmers TA, Jin X, Hsiao EC, Perez EA, Pierce RH, Chavin KD, Koniaris LG

An unusual development.

The American journal of medicine

Hsiao E, Charles R, Magid C, Nivatpumin P, Wiener CM

Growth differentiation factor-15/macrophage inhibitory cytokine-1 induction after kidney and lung injury.

Shock (Augusta, Ga.)

Zimmers TA, Jin X, Hsiao EC, McGrath SA, Esquela AF, Koniaris LG

Regulation of neuroendocrine differentiation in gastrointestinal carcinoid tumor cells by notch signaling.

The Journal of clinical endocrinology and metabolism

Nakakura EK, Sriuranpong VR, Kunnimalaiyaan M, Hsiao EC, Schuebel KE, Borges MW, Jin N, Collins BJ, Nelkin BD, Chen H, Ball DW

Cases from the Osler medical service at Johns Hopkins University.

The American journal of medicine

Maruthur NM, Hsiao EC, Lee J, Nivatpumin P

Transient absence of hepatic uptake on gallium-67 scintigraphy following fludarabine therapy.

Clinical nuclear medicine

Huynh T, Mansberg R, Hsiao E, Coyle L, Roach P

Pericarditis associated with cryptococcal meningitis on Ga-67 scintigraphy.

Clinical nuclear medicine

Hsiao E, Mansberg R, Huynh T, Roach P

Cytokine-responsive gene-2/IFN-inducible protein-10 expression in multiple models of liver and bile duct injury suggests a role in tissue regeneration.

Journal of immunology (Baltimore, Md. : 1950)

Koniaris LG, Zimmers-Koniaris T, Hsiao EC, Chavin K, Sitzmann JV, Farber JM

Characterization of growth-differentiation factor 15, a transforming growth factor beta superfamily member induced following liver injury.

Molecular and cellular biology

Hsiao EC, Koniaris LG, Zimmers-Koniaris T, Sebald SM, Huynh TV, Lee SJ

Structural and functional conservation of the Drosophila doublesex splicing enhancer repeat elements.

RNA (New York, N.Y.)

Hertel KJ, Lynch KW, Hsiao EC, Liu EH, Maniatis T