Current Research

Current Research

Pilot/Feasibility Projects

wentworth

Kelly Wentworth, MD

Department of Medicine
Identifying Therapies for Fibrous Dysplasia of the Bone Using a Drug Repositioning Strategy

 

Tools & Technology Projects

yoon

Daehyun Yoon, PhD

Department of Radiology & Biomedical Imaging
Ultra-short Echo Time MRI for Aiding in the Detection of Vessels in Cortical Bone Pore Space

 


Past CCMBM Projects 

Pilot/Feasibility Projects

2022-2023
kim

Tiffany Kim, MD

Department of Medicine
Bone marrow fat and skeletal health in type 2 diabetes

 

feeley

Brian Feeley, MD

Department of Orthopaedic Surgery
Cellular heterogeneity and sex based differences in human ACL injuries

 

 

2021-2022
moroika

Kazuhito Morioka, MD, PhD

Department of Orthopaedic Surgery
Nociplastic spinal cord-muscle loop in degenerative disc disease (DDD)

 

christine

Christine Hong, DMD, MS

 

Department of Orofacial Sciences
Role of p75NTR in Osteogenic Differentiation and Skeletal Development using Mouse Model
 

 

souza

Richard Souza, PhD, PT
 

Department of Physical Therapy & Rehabilitation Science
The Relationship between Gait Biomechanics and Exercise Induced Pain Flares in Patellofemoral Joint Osteoarthritis

 

 

 

2020-2021

Janet Lee, MD, MPH

Department of Medicine
Advanced ultrasound techniques for the evaluation of total knee arthroplasty

peodia

Valentina Pedoia, PhD

Department of Radiology and Biomedical Imaging
Multi-Task Deep Learning to Develop Automatic Scrapular Shape Extraction from Clinical MR

 

landsdwon

Drew Lansdown, MD

Department of Orthopaedic Surgery
Multi-Task Deep Learning to Develop Automatic Scrapular Shape Extraction from Clinical MR

 

2019-2020

Jeannie Bailey, PhD

Department of Orthopaedic Surgery
The mechanistic pathophysiology associated with paraspinal muscular degeneration and chronic low back pain

 

2018-2019
doug

Douglas Gould, PhD

Department of Opthamalogy
Mechanistic and Therapeutic Examination of Congenital Skeletal Defects in Col4a1 Mutant Mice

 

alfered

Alfred Kuo, MD PhD 

Department of Orthopaedic Surgery
Advanced ultrasound techniques for the evaluation of total knee arthroplasty

 


2017-2018

Edward Hsiao, MD, PhD 

Department of Medicine
Linking Innate Immune Dysfunction to Abnormal Bone Formation

 

 

 

2016-2017
brian

Brian Feeley, MD

Department of Orthopaedic Surgery
Co-Investigator: Jason Pomerantz, MD
Evaluation of satellite cell function and transplantation in rotator cuff injury

 

 

 

2015-2017
IMG

Wenhan Chang, PhD

Department of Medicine
Co-Investigator: Farzana Perwad, MD
Central Regulation of Ion transport and Skeletal Mineralization by FGF23 and Klotho

 

IMG

Sergey Magnitsky, PhD

Department of Radiology & Biomedical Imaging
Preclinical MR imaging and spectroscopy of bacteria infection in spinal disc

 

 

2015-2016
IMG

Douglas Gould, PhD

Department of Opthamalogy
Characterizing skeletal defects in Col4a1 mutant mice

 

 

 

2014-2015
IMG

Chelsea Bahney, PhD

Department of Orthopaedic Surgery
Building a Better Bone: Promoting Endochondral Ossification to Stimulate Vascularized Bone Regeneration

IMG

Xiaojuan Li, PhD

Departments of Radiology & Biomedical Imaging, Orthopaeic Surgey
Collaborator: Benjamin Ma, MD
In search of preventive measures for post-traumatic osteoarthritis: Synovial fluid characterization after anterior cruciate ligament injuries using novel techniques and approaches

 

IMG

Aaron Fields, PhD

Department of Orthopaedic Surgery
Endplate dysfunction in disc degeneration: investigating solute transport kinetics, disc cell viability, and new imaging methods

IMG

 

Xuhui Liu, MD

Department of Orthopaedic Surgery
Neuro-regulation of osteoporosis and heterotopic ossification after spinal cord injury

 

 

Tools and Technology Projects

2022-2023
IMG

Noah Bonnheim, PhD

Department of Orthopaedic Surgery
Biochemical mechanisms affecting T1ρ relaxation times in the intervertebral disc

 

2021-2022
IMG

Saghi Sadoughi, PhD

Department of Radiology
Establishing Time-Lapse HR-pQCT technique for Determining Total Bone Turnover in Patients with CKD 

IMG

 

Liping Wang, MD, PhD

Department of Medicine
Spatial Profiling WNT Signaling Pathway in PTH-treated Mouse Bones

 

2020-2021
IMG

Jinsook Suh, PhD

Department of Orofacial Sciences
Elucidating the epigenetic regulation of p75NTR in skeletal development

 

IMG

Po-Hung Wu, PhD

Department of Radiology & Biomedical Imaging
Cortical Bone Vasculature Imaging via Contrast-enhanced High-resolution Peripheral Quantitative Computed Tomography (HR-pQCT)

 

 

2019-2020

 

IMG

Tamara Alliston, PhD

Department of Orthopaedic Surgery
Development of M2Hbone - a web-based tool for identification of mouse genes relevant to human bone fragility

 

2018-2019
IMG

Musa Zaid, MD

Department of Orthopaedic Surgery
Patient-Specific Pathologic Femur Fracture Risk Assessment Using Geometrically Precise 3D-Printed Biomechanical Phantoms

 

 


2017-2018

Alan Dang, MD

Department of Orthopaedic Surgery
3D printing μCT data

 

 

 

2016-2017
IMG

Debbie Y. Dang, MD PhD 

Department of Orthopaedic Surgery
Collaborator: Alfred C. Kuo, MD PhD
Comparison of fracture healing in Cadherin 11 knockout and wild-type female and male mice

Valentina Pedoia, PhD 

Department of Radiology & Biomedical Imaging
Parallel Computing for Deep Learning Image Features Extraction

 

John B. Imboden, MD

Department of Medicine
Co-Investigators: Dolores M Shoback, MD
Dennis Black, PhD
Database Development for Studies of Disease Activity, Metabolic Indices and Inflammation

IMG

Anne Schafer, MD

Department of Medicine
Co-PI:John Shepherd, PhD
Co-Investigator: Tiffany Kim, MD
Trabecular Bone Score: Examining Vertebral Bone Quality in Gastric Bypass-Induced Bone Loss and in Other Musculoskeletal Conditions

 

 

2015-2016
IMG

Tamara Alliston, PhD

Department of Orthopaedic Surgery
High-throughput genomic analysis of TGFβ-responsive osteocyte mRNA and miR

 

IMG

Aaron Fields, PhD

Department of Orthopaedic Surgery
Measurement of the effect of cartilage endplate permeability on disc cell function using in situ hybridization

 

 

2014-2015
IMG

Ursula Heimeier, MD

Department of Radiology & Biomedical Imaging
The role of miRNAs in human diabetic bone disease and their association with HRpQCT-derived bone microarchitectural parameter

 

IMG

Shingo Kajimura, PhD

Department of Cell & Tissue Biology
Molecular links between BAT and the musculoskeletal system

 

 

Core Voucher Projects

2018-2019
IMG

Daniel Clark, DDS, PhD

Department of Orofacial Sciences
Age-Related Changes of Macrophage: Implications for Immunomodulation in Periodontal Disease

IMG

Caitlin Chambers, MD

Department of Orthopaedic Surgery
Risk Factors For Progressive Degenerative Changes After Meniscal Root Tears as Defined By Longitudinal Magnetic Resonance Imaging

 

Janet Lee, MD, MPH

Department of Medicine
Bone density, structure, and estimated strength in transgender youth receiving pubertal suppression in early puberty