Systems Biology

My research interests include: (1) adeno-associated viral vector (AAV)-mediated tissue specific gene transfer and gene expression; (2) the pathogenesis of cerebrovascular malformation; (3) development of new therapies for ischemic stroke and arteriovenous malformation; and (4) the impact of aging, peripheral injury (such as bone fracture), and innate immune response on stroke recovery.

Dr. Dolores Shoback cares for patients with a variety of disorders related to the endocrine system, focusing particularly on metabolic bone disease, parathyroid disorders and osteoporosis. She also directs UCSF's physician training program in diabetes, endocrinology and metabolism.

Shoback's research interests include metabolic bone disease, the calcium-sensing receptor and parathyroid hormone.

Dr. Schwartz's research focuses on the epidemiology and etiology of fractures, osteoporosis, and falls in older adults with diabetes. She is currently the PI of ACCORD BONE, an ancillary study to the ACCORD trial in older adults with type 2 diabetes, examining the effects of intensive glycemic control and TZD use on skeletal health. She is pursuing investigations into the reasons for reduced bone strength in type 2 diabetes, including the role of marrow fat, advanced glycation endproducts, and cortical porosity. Dr.

Mary Nakamura received her B.A. from Swarthmore College, her M.D. from Yale and trained in internal medicine at the University of California, San Francisco. She completed her rheumatology training at Johns Hopkins and UCSF. She did her post doctoral work at UCSF under the mentorship of Bill Seaman. She is a basic-translational researcher focused on studies in the field of osteoimmunology. She leads the Rheumatoid Arthritis Clinic at UCSF Parnassus and is a clinical attending at the SF VA HCS.

Dr. Meir T. Marmor has a strong clinical interest in treatment of complex fractures, fracture complications, and fractures in the elderly population as well as in joint replacement surgery. His clinical practice involves use of advanced imaging techniques, computer assisted and minimally invasive surgery. Dr. Marmor practice includes treatment of all long-bone and intra-articular fractures and their complications, such as infected fracture fixations and fracture non-unions. Dr.

Abnormal excitability contributes to neurologic disease pathogenesis either by impairing cell function or by increasing cellular susceptibility to injury. In most neurologic diseases, the pathologic process does not involve the entire neuromuscular unit. Instead, only specific subsets of neurons, glial cells, or muscle fibers are injured or die, and the nature of this selective injury determines the symptoms and clinical course of each disease.

Ralph Marcucio was born in and grew up in Amsterdam, N.Y. Ralph began his research career as an intern at The Boyce Thompson Institute while he was an undergraduate at Cornell University in Ithaca, NY. After receiving his Bachelor's Degree from Cornell University in 1990, Ralph was accepted intoCornell University's School of Agriculture PhD program. He completed his PhD in 1995.

Dr. Ma is Director of the UCSF IBD Center and Chief of the Division of Gastroenterology. He oversees translational and basic research in IBD and related inflammatory diseases.