Hua Su, MD

Professor
Anesthesia
+1 415 476-0141

My research interests include: (1) adeno-associated viral vector (AAV)-mediated tissue specific gene transfer and gene expression; (2) the pathogenesis of cerebrovascular malformation; (3) development of new therapies for ischemic stroke and arteriovenous malformation; and (4) the impact of aging, peripheral injury (such as bone fracture), and innate immune response on stroke recovery.

Interests: Impact of bone fracture on stroke recovery, the influence of stroke on bone health, neuroinflammaiton, stroke, vascular malformation, monocyte polarization, gene therapy, target gene delivery, angiogenesis

Publications: 

Abstract 116: Increased Collagen I/Collagen III Ratio is Associated With Hemorrhage in Brain Arteriovenous Malformations in Human and Mouse.

Stroke

Zahra Shabani nabikandi, Joana Schurger, Alka Yadav, Rich Liang, Kelly Press, Shantel Weinsheimer, Annika Schmidt, Helen Kim, Hua Su

Abstract TMP3: Overexpression of Alk1 in Brain Endothelial Cells Alleviates the Severity of Brain Arteriovenous Malformations in Alk1 Mutant Mice.

Stroke

Alka Yadav, Rich Liang, Kelly Press, Annika Schmidt, Zahra Shabani nabikandi, Sally Huang, Trevor Gonzalez, Aravind Asokan, Hua Su

Abstract TMP5: Mutation of Pdgfrß Enhances the Severity of Brain Arteriovenous Malformation on Endoglin Mutant Mice Through Exacerbation of Angiogenesis and Inflammation.

Stroke

Alka Yadav, Leandro Barbosa Do Prado, Chaoliang Tang, Sonali Shaligram, Rich Liang, Kelly Press, Jasneet Dhaliwal, Ethan A Winkler, Hua Su

Abstract TP2: Increase of EphrinB2/EphB4 Signaling Reduces the Severity of Brain Arteriovenous Malformation in Endoglin Deficient Mice Through Reduction of Angiogenesis and Inflammation.

Stroke

Zahra Shabani nabikandi, Leandro Barbosa Do Prado, Alka Yadav, Rui Zhang, Wan Zhu, Sonali Shaligram, Joana Schuger, Rich Liang, Kelly Press, Hua Su

Increased Collagen I/Collagen III Ratio Is Associated with Hemorrhage in Brain Arteriovenous Malformations in Human and Mouse.

Cells

Shabani Z, Schuerger J, Zhu X, Tang C, Ma L, Yadav A, Liang R, Press K, Weinsheimer S, Schmidt A, Wang C, Sekhar A, Nelson J, Kim H, Su H

Abstract 52: Prevalence Of Somatic Activating Kras Mutations In Pediatric And Adult Sporadic Brain Arteriovenous Malformations.

Stroke

Ethan A Winkler, Joseph Garcia, Cynthia Tsang, Jeffrey Nelson, Charles McCulloch, Shantel Weinsheimer, Christine K Fox, Heather Fullerton, Nerissa Ko, Hua Su, Tomasz Nowakowski, Daniel L Cooke, Steven Hetts, Ekin Guney, MELIKE PEKMEZCI, Tarik Tihan, Michael Lawton, Adib Abla, Nalin Gupta, Helen Kim

Cellular loci involved in the development of brain arteriovenous malformations.

Frontiers in human neuroscience

Shabani Z, Schuerger J, Su H

Remodeling of the Neurovascular Unit Following Cerebral Ischemia and Hemorrhage.

Cells

Sato Y, Falcone-Juengert J, Tominaga T, Su H, Liu J

N-Oleoyl dopamine induces IL-10 via central nervous system TRPV1 and improves endotoxemia and sepsis outcomes.

Journal of neuroinflammation

Joffre J, Wong E, Lawton S, Lloyd E, Nguyen N, Xu F, Sempio C, Kobzik L, Zlatanova I, Schumacher M, Klawitter J, Su H, Rabl K, Wilhelmsen K, Yeh CC, Hellman J

Abstract 19: Long-lasting Post-stroke Memory Dysfunction In Aged Mice Is Like Due To Exacerbated Hippocampal Inflammation And Synapses Removing.

Stroke

Peipei Pan, Qifeng Li, Zhanqiang Wang, Rich Liang, Kang Huo, Eric Ding, Chandler Beon, Kelly Press, Hua Su

Abstract TMP5: Bone Marrow-derived And Clonally Expanded Alk1- Endothelial Cells Contribute To Brain Arteriovenous Malformation In Mice.

Stroke

Sonali Shaligram, Rui Zhang, Wan Zhu, Li Ma, Man Luo, Qiang Li, Miriam Weiss, Thomas Arnold, Santander Grez NG, Rich Liang, Leandro Predo, Chaoliang Tang, Peipei Pan, Hua Su

Bone Marrow-Derived Alk1 Mutant Endothelial Cells and Clonally Expanded Somatic Alk1 Mutant Endothelial Cells Contribute to the Development of Brain Arteriovenous Malformations in Mice.

Translational stroke research

Shaligram SS, Zhang R, Zhu W, Ma L, Luo M, Li Q, Weiss M, Arnold T, Santander N, Liang R, do Prado L, Tang C, Pan F, Oh SP, Pan P, Su H

Somatic mosaicism in the MAPK pathway in sporadic brain arteriovenous malformation and association with phenotype.

Journal of neurosurgery

Gao S, Nelson J, Weinsheimer S, Winkler EA, Rutledge C, Abla AA, Gupta N, Shieh JT, Cooke DL, Hetts SW, Tihan T, Hess CP, Ko N, Walcott BP, McCulloch CE, Lawton MT, Su H, Pawlikowska L, Kim H

Review of treatment and therapeutic targets in brain arteriovenous malformation.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Pan P, Weinsheimer S, Cooke D, Winkler E, Abla A, Kim H, Su H

Proof-of-concept single-arm trial of bevacizumab therapy for brain arteriovenous malformation.

BMJ Neurology Open

Muster R, Ko N, Smith W, Su H, Dickey MA, Nelson J, McCulloch CE, Sneed PK, Clarke JL, Saloner DA, Eisenmenger L, Kim H, Cooke DL

Abstract P795: Activating Transcription Factor 3 Improves Stroke Recovery Through Reduction of Neuronal Damage and Neuroinflammation.

Stroke

Zhanqiang Wang, Peipei Pan, Rich Liang, Qifeng Li, Janothon Pan, Zhonghui Guan, Hua Su

Reduction of neuroinflammation alleviated mouse post bone fracture and stroke memory dysfunction.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Huo K, Wei M, Zhang M, Wang Z, Pan P, Shaligram SS, Huang J, Prado LBD, Wong J, Su H

Bone Fracture Enhanced Blood-Brain Barrier Breakdown in the Hippocampus and White Matter Damage of Stroke Mice

International Journal of Molecular Science.

J Huang, H Lyu, K Huo, LB Do Prado, C Tang,Z Wang, Q Li, J Wong, and H Su

Bone Fracture Enhanced Blood-Brain Barrier Breakdown in the Hippocampus and White Matter Damage of Stroke Mice.

International journal of molecular sciences

Huang J, Lyu H, Huo K, Do Prado LB, Tang C, Wang Z, Li Q, Wong J, Su H

The role of mural cells in hemorrhage of brain arteriovenous malformation.

Brain Hemorrhages

Pan P, Shaligram SS, Do Prado LB, He L, Su H

Reduction of endoglin receptor impairs mononuclear cell-migration.

Exploration of medicine

Han Z, Shaligram S, Faughnan ME, Clark D, Sun Z, Su H

Concurrent presentation of brain arteriovenous malformation, peripheral arteriovenous malformation, and cerebellar astrocytoma: Case report.

Interdisciplinary neurosurgery : Advanced techniques and case management

Gautam A, Sun Z, Winkler E, Su H, McCalmont TH, Kim H, Tihan T, Hoffman WY, Dowd CF, Frieden IJ, Cooke DL

Abstract TP118: Activation of Alpha-7 Nicotinic Acetylcholine Receptor Improved Long-Term Cognitive Function of Mice With Long-Bone Fracture and Stroke.

Stroke

Kang Hou, Meng Wei, Meng Zhang, Zhanqiang Wang, Sonali Shaligram, Jinhao Huang, Leandro Barbosa Do Prado, Julia Wong, Rose Carion, Tuanpeng Sun, Lei Zhan, Hua SU

Abstract TP119: Tibia Fracture Leads to Long-Lasting Memory Dysfunction in Mice Through Enhanced Blood-Brain Barrie Breakdown in the Hippocampus and White Matter Damage.

Stroke

Jinhao Huang, Haiyan Lyu, Kang Hou, Leandro Barbosa Do Prado, Chaoliang Tang, Zhanqiang Wang, Julia Wong, Hua Su

Recent Advances in Basic Research for Brain Arteriovenous Malformation.

International journal of molecular sciences

Barbosa Do Prado L, Han C, Oh SP, Su H

Risk factors for hemorrhage of brain arteriovenous malformation.

CNS neuroscience & therapeutics

Shaligram SS, Winkler E, Cooke D, Su H

Effect of elevation of vascular endothelial growth factor level on exacerbation of hemorrhage in mouse brain arteriovenous malformation.

Journal of neurosurgery

Cheng P, Ma L, Shaligram S, Walker EJ, Yang ST, Tang C, Zhu W, Zhan L, Li Q, Zhu X, Lawton MT, Su H

Abstract 66: Reduction of the Number of Endothelial Cells Harboring Mutations of AVM Causative Genes Lessens Brain AVM Severity.

Stroke

Sonali S Shaligram, Rui Zhang, Cameron M McDougall, Wan Zhu, Wan Zhu, Li Ma, Michael L Lawton, Hua Su

Abstract TMP105: Elevation of VEGF Exacerbates Hemorrhage in Mouse Brain Arteriovenous Malformation.

Stroke

Li Ma, Philip Cheng, Sonali Shaligram, Espen J Walker, Shun-Tai Yang, Chaoliang Tang, Wan Zhu, Qiang Li, Xiaonan Zhu, Hua Su

Fracture shortly before stroke in mice leads to hippocampus inflammation and long-lasting memory dysfunction.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Li Z, Wei M, Lyu H, Huo K, Wang L, Zhang M, Su H

Induction of Brain Arteriovenous Malformation Through CRISPR/Cas9-Mediated Somatic Alk1 Gene Mutations in Adult Mice.

Translational stroke research

Zhu W, Saw D, Weiss M, Sun Z, Wei M, Shaligram S, Wang S, Su H

Reductions in brain pericytes are associated with arteriovenous malformation vascular instability.

Journal of neurosurgery

Winkler EA, Birk H, Burkhardt JK, Chen X, Yue JK, Guo D, Rutledge WC, Lasker GF, Partow C, Tihan T, Chang EF, Su H, Kim H, Walcott BP, Lawton MT

Risk factors for ischemic stroke post bone fracture.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

An Q, Chen Z, Huo K, Su H, Qu QM

Impact of Bone Fracture on Ischemic Stroke Recovery.

International journal of molecular sciences

Wei M, Lyu H, Huo K, Su H

Thalidomide Reduces Hemorrhage of Brain Arteriovenous Malformations in a Mouse Model.

Stroke

Zhu W, Chen W, Zou D, Wang L, Bao C, Zhan L, Saw D, Wang S, Winkler E, Li Z, Zhang M, Shen F, Shaligram S, Lawton M, Su H

Animal Models and Prospective Therapeutic Targets for Brain Arteriovenous Malformation.

Molecular, Genetic, and Cellular Advances in Cerebrovascular Diseases

Wan Zhu, Rui Zhang, Li Ma, Hua Su

Single-cell RNA sequencing reveals gene expression signatures of breast cancer-associated endothelial cells.

Oncotarget

Sun Z, Wang CY, Lawson DA, Kwek S, Velozo HG, Owyong M, Lai MD, Fong L, Wilson M, Su H, Werb Z, Cooke DL

Inflammation and genetic factors in stroke pathogenesis.

Neuroimmunology and neuroinflammation

Su H

The roles of endoglin gene in cerebrovascular diseases.

Neuroimmunology and neuroinflammation

Zhu W, Ma L, Zhang R, Su H

Endovascular Biopsy: In Vivo Cerebral Aneurysm Endothelial Cell Sampling and Gene Expression Analysis.

Translational stroke research

Cooke DL, McCoy DB, Halbach VV, Hetts SW, Amans MR, Dowd CF, Higashida RT, Lawson D, Nelson J, Wang CY, Kim H, Werb Z, McCulloch C, Hashimoto T, Su H, Sun Z

381 Reductions in Brain Pericytes are Associated with Arteriovenous Malformation Vascular Instability.

Neurosurgery

Ethan A Winkler, Harjus Birk, Jan-Karl Burkhardt, Xiaolin Chen, John K Yue, Diana Guo, William Caleb Rutledge, George Lasker, Tarik Tihan, Edward F Chang, Hua Su, Helen Kim, Brian Patrick Walcott, Michael T Lawton

Higher Flow Is Present in Unruptured Arteriovenous Malformations With Silent Intralesional Microhemorrhages.

Stroke

Chen X, Cooke DL, Saloner D, Nelson J, Su H, Lawton MT, Hess C, Tihan T, Zhao Y, Kim H

Soluble FLT1 Gene Therapy Alleviates Brain Arteriovenous Malformation Severity.

Stroke

Zhu W, Shen F, Mao L, Zhan L, Kang S, Sun Z, Nelson J, Zhang R, Zou D, McDougall CM, Lawton MT, Vu TH, Wu Z, Scaria A, Colosi P, Forsayeth J, Su H

Morbidity after Hemorrhage in Children with Untreated Brain Arteriovenous Malformation.

Cerebrovascular diseases (Basel, Switzerland)

Ma L, Kim H, Chen XL, Wu CX, Ma J, Su H, Zhao Y

Abstract 198: Endovascular Biopsy: in vivo Brain Aneurysm Endothelial Cell Sampling and Gene Expression Analysis.

Stroke

Daniel L Cooke, Van Halbach, Steven Hetts, Matthew Amans, Christopher Dowd, Randall Higashida, Devon Lawson, Jeffrey Nelson, David McCoy, Helen Kim, Tomoki Hashimoto, Zena Werb, Hua Su, Zhengda Sun

Abstract TMP111: Thalidomide and Lenalidomide Treatment Reduces Microhemorrhage in Brain Arteriovenous Malformation in Mice Through Increasing Mural Cell Coverage.

Stroke

Wan Zhu, Dingquan Zou, Wanqiu Chen, Chen Bao, Rui Zhang, Lei Zhan, Zhengxi Li, Meng Zhang, Ethan Winkler, Michael T. Lawton, Hua Su

Abstract TP445: Bevacizumab Therapy for Brain Arteriovenous Malformations.

Stroke

Daniel L Cooke, Helen Kim, Wade Smith, Michael Lawton, Jennifer Clarke, David Saloner, Nerissa Ko, Patricia Sneed, Charles McCulloch, Hua Su

Gene Therapy for Stroke.

Translational Research in Stroke

Fanxia Shen, Hua Su

Activation of Alpha-7 Nicotinic Acetylcholine Receptor Reduces Brain Edema in Mice with Ischemic Stroke and Bone Fracture.

Molecular neurobiology

Zou D, Luo M, Han Z, Zhan L, Zhu W, Kang S, Bao C, Li Z, Nelson J, Zhang R, Su H

Integrin ß8 Deletion Enhances Vascular Dysplasia and Hemorrhage in the Brain of Adult Alk1 Heterozygous Mice.

Translational stroke research

Ma L, Shen F, Jun K, Bao C, Kuo R, Young WL, Nishimura SL, Su H

Persistent infiltration and pro-inflammatory differentiation of monocytes cause unresolved inflammation in brain arteriovenous malformation.

Angiogenesis

Zhang R, Han Z, Degos V, Shen F, Choi EJ, Sun Z, Kang S, Wong M, Zhu W, Zhan L, Arthur HM, Oh SP, Faughnan ME, Su H

Morphometric characterization of brain arteriovenous malformations for clinical and radiological studies to identify silent intralesional microhemorrhages.

Clinical neuropathology

Pekmezci M, Nelson J, Su H, Hess C, Lawton MT, Sonmez M, Young WL, Kim H, Tihan T

Bone Fracture Pre-Ischemic Stroke Exacerbates Ischemic Cerebral Injury in Mice.

PloS one

Wang L, Kang S, Zou D, Zhan L, Li Z, Zhu W, Su H

SIRT3 Acts as a Neuroprotective Agent in Rotenone-Induced Parkinson Cell Model.

Neurochemical research

Zhang JY, Deng YN, Zhang M, Su H, Qu QM

Impact and risk factors of post-stroke bone fracture.

World journal of experimental medicine

Huo K, Hashim SI, Yong KL, Su H, Qu QM

Abstract 54: Soluble FLT1 Gene Therapy Through Systemic Viral Delivery Reduces the Severity of Mouse Brain Arteriovenous Malformation.

Stroke

Wan Zhu, Fanxia Shen, Shuai Kang, Lei Mao, Zhengda Sun, Dingquan Zou, Rui Zhang, Lei Zhan, John Forsayeth, Hua Su

Abstract WP111: Activation of a7 Nicotinic Acetylcholine Receptor Improves Blood-Brain Barrier Integrity in Mice with Ischemic Stroke and Bone Fracture.

Stroke

Dingquan Zou, Zhenyi Han, Lei Zhan, Wan Zhu, Shuai Kang, Chen Bao, Alireza Sadighi, Zhao Li, Jeffrey Nelson, Rui Zhang, Hua Su

12 Genetics and Vascular Biology of Angiogenesis and Vascular Malformations.

Stroke

Helen Kim, Ludmila Pawlikowska, Hua Su, William L. Young

Vascular Integrity in the Pathogenesis of Brain Arteriovenous Malformation.

Acta neurochirurgica. Supplement

Zhang R, Zhu W, Su H

Endovascular biopsy: Strategy for analyzing gene expression profiles of individual endothelial cells obtained from human vessels?.

Biotechnology reports (Amsterdam, Netherlands)

Sun Z, Lawson DA, Sinclair E, Wang CY, Lai MD, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Werb Z, Su H, Cooke DL

Review

The role of macrophage in the pathogenesis of brain arteriovenous malformation

Ma L, Guo Y, Zhao YL, Su H

Inhibition of pathological brain angiogenesis through systemic delivery of AAV vector expressing soluble FLT1.

Gene therapy

Shen F, Mao L, Zhu W, Lawton MT, Pechan P, Colosi P, Wu Z, Scaria A, Su H

385. Intravenous Delivery of AAV9-CMV-sFLT1 Reduces the Severity of Brain Arteriovenous Malformation Without Causing Significant Side Effects in a Mouse Model.

Molecular Therapy

Wan Zhu, Fanxia Shen, Lei Zhan, Shuai Kang, Rui Zhang, Dingquan Zou, John Forsayeth, Zhijian Wu, Peter Colosi, Hua Su

Endovascular biopsy: Technical feasibility of novel endothelial cell harvesting devices assessed in a rabbit aneurysm model.

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences

Cooke DL, Bauer D, Sun Z, Stillson C, Nelson J, Barry D, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Su H, Saeed MM

Endovascular biopsy: Technical feasibility of novel endothelial cell harvesting devices assessed in a rabbit aneurysm model.

Interventional Neuroradiology

Daniel L Cooke, Diana Bauer, Zhengda Sun, Carol Stillson, Jeffrey Nelson, David Barry, Steven W Hetts, Randall T Higashida, Christopher F Dowd, Van V Halbach, Hua Su, Maythem M Saeed

Adult mouse venous hypertension model: common carotid artery to external jugular vein anastomosis.

Journal of visualized experiments : JoVE

Yang ST, Rodriguez-Hernandez A, Walker EJ, Young WL, Su H, Lawton MT

Endovascular Biopsy: Technical Feasibility of Novel Endothelial Cell Harvesting Devices Assessed in a Rabbit Aneurysm Model.

Interventional Neuroradiology

Daniel L. Cooke, Diana Bauer, Zhengda Sun, Carol Stillson, Jeffrey Nelson, David Barry, Steven W. Hetts, Randall T. Higashida, Christopher F. Dowd, Van V. Halbach, Hua Su, Maythem M. Saeed

Endovascular treatment of severe acute basilar artery occlusion

J Clin Neurosci

Wang L, Shi W, Su Z, Liu X, Su H, Liu J, Liu Z

Targeted Gene Therapy for Ischemic Stroke.

Gene Delivery and Therapy for Neurological Disorders

Fanxia Shen, Hua Su

The Role of Macrophage in the Pathogenesis of Brain Arteriovenous Malformation.

International journal of hematology research

Ma L, Guo Y, Zhao YL, Su H

Endothelial cell high-enrichment from endovascular biopsy sample by laser capture microdissection and fluorescence activated cell sorting.

Journal of biotechnology

Sun Z, Su H, Long B, Sinclair E, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Cooke DL

Distinctive distribution of lymphocytes in unruptured and previously untreated brain arterviovenous malformation

Neuroimmunology and neuroinflammation

Guo Y, Tihan T, Lawton MT, Kim H, Young WL, Zhao Y, Su H.

Endovascular treatment of severe acute basilar artery occlusion.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Wang L, Shi W, Su Z, Liu X, Su H, Liu J, Liu Z, Lawton MT

Endoglin deficiency impairs stroke recovery.

Stroke

Shen F, Degos V, Chu PL, Han Z, Westbroek EM, Choi EJ, Marchuk D, Kim H, Lawton MT, Maze M, Young WL, Su H

Brain arteriovenous malformation modeling, pathogenesis, and novel therapeutic targets.

Translational stroke research

Chen W, Choi EJ, McDougall CM, Su H

Abstract W P98: Activation of a7 Nicotinic Acetylcholine Receptor Reduces Pro-Inflammatory Macrophage and Improves Ischemic Stroke Recovery.

Stroke

Zhenying Han, Fanxia Shen, Yue He, Vincent Degos, Marine Camus, Mamta Wankhede, Mervyn Maze, William L. Young, Hua Su

De novo cerebrovascular malformation in the adult mouse after endothelial Alk1 deletion and angiogenic stimulation.

Stroke

Chen W, Sun Z, Han Z, Jun K, Camus M, Wankhede M, Mao L, Arnold T, Young WL, Su H

Development of the central nervous system vasculature and the pathogenesis of brain arteriovenous malformations.

Comprehensive Management of Arteriovenous Malformations of the Brain and Spine

Steven W. Hetts, Hua Su, Tarik Tihan, Tomoki Hashimoto, Ludmila Pawlikowska, Michael T. Lawton

Distinctive distribution of lymphocytes in unruptured and previously untreated brain arteriovenous malformation.

Neuroimmunology and neuroinflammation

Guo Y, Tihan T, Kim H, Hess C, Lawton MT, Young WL, Zhao Y, Su H

ERRATUM TO: Induction of Brain Arteriovenous Malformation in the Adult Mouse.

Cerebral Angiogenesis

Wanqiu Chen, William L. Young, Hua Su

Induction of brain arteriovenous malformation in the adult mouse.

Methods in molecular biology (Clifton, N.J.)

Chen W, Young WL, Su H

Endovascular biopsy: evaluating the feasibility of harvesting endothelial cells using detachable coils.

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences

Cooke DL, Su H, Sun Z, Guo Y, Guo D, Saeed MM, Hetts SW, Higashida RT, Dowd CF, Young WL, Halbach VV

Bone fracture exacerbates murine ischemic cerebral injury.

Anesthesiology

Degos V, Maze M, Vacas S, Hirsch J, Guo Y, Shen F, Jun K, van Rooijen N, Gressens P, Young WL, Su H

Abstract TMP116: AAV-sFLT: A Potential Therapeutic Agent for the Treatment of Brain Angiogenic Diseases.

Stroke

Lei Mao, Fanxia Shen, Wanqiu Chen, Babatunde Akinpelu, Michael T. Lawton, William L. Young, Hua Su

Abstract TMP118: Alk1 Deficiency Impairs Mural Cell Recruitment During Brain Angiogenesis.

Stroke

Wanqiu Chen, Yi Guo, Kristine Jun, Mamta Wankhede, Hua Su, William L. Young

Abstract TMP69: Endoglin Deficiency Exacerbates Ischemic Brain Injury.

Stroke

Fanxia Shen, Vincent Degos, Zhenying Han, Eun-Jung Choi, William L. Young, Hua Su

Reduced mural cell coverage and impaired vessel integrity after angiogenic stimulation in the Alk1-deficient brain.

Arteriosclerosis, thrombosis, and vascular biology

Chen W, Guo Y, Walker EJ, Shen F, Jun K, Oh SP, Degos V, Lawton MT, Tihan T, Davalos D, Akassoglou K, Nelson J, Pile-Spellman J, Su H, Young WL

Perlecan domain V is upregulated in human brain arteriovenous malformation and could mediate the vascular endothelial growth factor effect in lesional tissue.

Neuroreport

Kahle MP, Lee B, Pourmohamad T, Cunningham A, Su H, Kim H, Chen Y, McCulloch CE, Barbaro NM, Lawton MT, Young WL, Bix GJ

Ferumoxytol-enhanced MRI to Image Inflammation within Human Brain Arteriovenous Malformations: A Pilot Investigation.

Translational stroke research

Hasan DM, Amans M, Tihan T, Hess C, Guo Y, Cha S, Su H, Martin AJ, Lawton MT, Neuwelt EA, Saloner DA, Young WL

Perlecan domain V is upregulated in human brain arteriovenous malformation and could mediate the vascular endothelial growth factor effect in lesional tissue.

Neuroreport

Michael P. Kahle, Boyeon Lee, Tony Pourmohamad, Austin Cunningham, Hua Su, Helen Kim, Yongmei Chen, Charles E. McCulloch, Nicholas M. Barbaro, Michael T. Lawton, William L. Young, Gregory J. Bix

Minimal homozygous endothelial deletion of Eng with VEGF stimulation is sufficient to cause cerebrovascular dysplasia in the adult mouse.

Cerebrovascular diseases (Basel, Switzerland)

Choi EJ, Walker EJ, Shen F, Oh SP, Arthur HM, Young WL, Su H

Silent intralesional microhemorrhage as a risk factor for brain arteriovenous malformation rupture.

Stroke

Guo Y, Saunders T, Su H, Kim H, Akkoc D, Saloner DA, Hetts SW, Hess C, Lawton MT, Bollen AW, Pourmohamad T, McCulloch CE, Tihan T, Young WL, University of California, San Francisco Brain Arteriovenous Malformation (UCSF bAVM) Study Project

Abstract 2217: Magnetic Resonance Blood-Brain Barrier Permeability Measurements To Predict Hemorrhagic Transformation In A Rat Model Of Ischemic Stroke.

Stroke

Angelika Hoffmann, Jo¨rg Bredno, Michael F Wendland, Nikita Derugin, Jason Hom, Hua Su, Peter T Ohara, William L Young, Max Wintermark

Abstract 3190: Increased Inflammatory Response in Aged Mice is Associated with More Severe Neuronal Injury at the Acute Stage of Ischemic Stroke.

Stroke

Fanxia Shen, Lidan Jiang, Robert Kuo, Vincent Degos, Espen J. Walker, Hua Su, William L. Young

Sca-1+ cardiosphere-derived cells are enriched for Isl1-expressing cardiac precursors and improve cardiac function after myocardial injury.

PloS one

Ye J, Boyle A, Shih H, Sievers RE, Zhang Y, Prasad M, Su H, Zhou Y, Grossman W, Bernstein HS, Yeghiazarians Y

Cerebrovascular Casting of the Adult Mouse for 3D Imaging and Morphological Analysis.

Journal of visualized experiments : JoVE

Walker EJ, Shen F, Young WL, Su H

Cerebrovascular casting of the adult mouse for 3D imaging and morphological analysis.

Journal of visualized experiments : JoVE

Walker EJ, Shen F, Young WL, Su H

Oligogenesis and oligodendrocyte progenitor maturation vary in different brain regions and partially correlate with local angiogenesis after ischemic stroke.

Translational stroke research

Jiang L, Shen F, Degos V, Schonemann M, Pleasure SJ, Mellon SH, Young WL, Su H

Coexpression of angiopoietin-1 with VEGF increases the structural integrity of the blood-brain barrier and reduces atrophy volume.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Shen F, Walker EJ, Jiang L, Degos V, Li J, Sun B, Heriyanto F, Young WL, Su H

Arteriovenous malformation in the adult mouse brain resembling the human disease.

Annals of neurology

Walker EJ, Su H, Shen F, Choi EJ, Oh SP, Chen G, Lawton MT, Kim H, Chen Y, Chen W, Young WL

Brain arteriovenous malformation pathogenesis: a response-to-injury paradigm.

Acta neurochirurgica. Supplement

Kim H, Su H, Weinsheimer S, Pawlikowska L, Young WL

Treatment of focal brain ischemia with viral vector-mediated gene transfer.

Methods in molecular biology (Clifton, N.J.)

Su H, Yang GY

Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124.

Science (New York, N.Y.)

Kuhnert F, Mancuso MR, Shamloo A, Wang HT, Choksi V, Florek M, Su H, Fruttiger M, Young WL, Heilshorn SC, Kuo CJ

Evidence of endothelial progenitor cells in the human brain and spinal cord arteriovenous malformations.

Neurosurgery

Gao P, Chen Y, Lawton MT, Barbaro NM, Yang GY, Su H, Ling F, Young WL

VEGF Induces More Severe Cerebrovascular Dysplasia in Endoglin than in Alk1 Mice.

Translational stroke research

Hao Q, Zhu Y, Su H, Shen F, Yang GY, Kim H, Young WL

MicroRNA-9 coordinates proliferation and migration of human embryonic stem cell-derived neural progenitors.

Cell stem cell

Delaloy C, Liu L, Lee JA, Su H, Shen F, Yang GY, Young WL, Ivey KN, Gao FB

Endothelial progenitor cell transplantation improves long-term stroke outcome in mice.

Annals of neurology

Fan Y, Shen F, Frenzel T, Zhu W, Ye J, Liu J, Chen Y, Su H, Young WL, Yang GY

Reduced expression of integrin alphavbeta8 is associated with brain arteriovenous malformation pathogenesis.

The American journal of pathology

Su H, Kim H, Pawlikowska L, Kitamura H, Shen F, Cambier S, Markovics J, Lawton MT, Sidney S, Bollen AW, Kwok PY, Reichardt L, Young WL, Yang GY, Nishimura SL

Attenuation of brain response to vascular endothelial growth factor-mediated angiogenesis and neurogenesis in aged mice.

Stroke

Gao P, Shen F, Gabriel RA, Law D, Yang EY, Yang E, Yang GY, Young WL, Su H

Combining angiogenic gene and stem cell therapies for myocardial infarction.

The journal of gene medicine

Pons J, Huang Y, Takagawa J, Arakawa-Hoyt J, Ye J, Grossman W, Kan YW, Su H

Soluble endoglin modulates aberrant cerebral vascular remodeling.

Annals of neurology

Chen Y, Hao Q, Kim H, Su H, Letarte M, Karumanchi SA, Lawton MT, Barbaro NM, Yang GY, Young WL

Restoring transcription factor HoxA5 expression inhibits the growth of experimental hemangiomas in the brain.

Journal of neuropathology and experimental neurology

Zhu Y, Cuevas IC, Gabriel RA, Su H, Nishimura S, Gao P, Fields A, Hao Q, Young WL, Yang GY, Boudreau NJ

Nonischemic cerebral venous hypertension promotes a pro-angiogenic stage through HIF-1 downstream genes and leukocyte-derived MMP-9.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Gao P, Zhu Y, Ling F, Shen F, Lee B, Gabriel RA, Hao Q, Yang GY, Su H, Young WL

Increased tissue perfusion promotes capillary dysplasia in the ALK1-deficient mouse brain following VEGF stimulation.

American journal of physiology. Heart and circulatory physiology

Hao Q, Su H, Marchuk DA, Rola R, Wang Y, Liu W, Young WL, Yang GY

Contribution of bone marrow-derived cells associated with brain angiogenesis is primarily through leukocytes and macrophages.

Arteriosclerosis, thrombosis, and vascular biology

Hao Q, Liu J, Pappu R, Su H, Rola R, Gabriel RA, Lee CZ, Young WL, Yang GY

VEGF improves survival of mesenchymal stem cells in infarcted hearts.

Biochemical and biophysical research communications

Pons J, Huang Y, Arakawa-Hoyt J, Washko D, Takagawa J, Ye J, Grossman W, Su H

Overexpression of netrin-1 induces neovascularization in the adult mouse brain.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Fan Y, Shen F, Chen Y, Hao Q, Liu W, Su H, Young WL, Yang GY

Additive effect of AAV-mediated angiopoietin-1 and VEGF expression on the therapy of infarcted heart.

International journal of cardiology

Su H, Takagawa J, Huang Y, Arakawa-Hoyt J, Pons J, Grossman W, Kan YW

AAV serotype 1 mediates more efficient gene transfer to pig myocardium than AAV serotype 2 and plasmid.

The journal of gene medicine

Su H, Yeghiazarians Y, Lee A, Huang Y, Arakawa-Hoyt J, Ye J, Orcino G, Grossman W, Kan YW

Development of a cerebral microvascular dysplasia model in rodents.

Acta neurochirurgica. Supplement

Su H, Hao Q, Shen F, Zhu Y, Lee CZ, Young WL, Yang GY

Establishing a novel single-copy primer-internal intron-spanning PCR (spiPCR) procedure for the direct detection of gene doping.

Exercise immunology review

Beiter T, Zimmermann M, Fragasso A, Armeanu S, Lauer UM, Bitzer M, Su H, Young WL, Niess AM, Simon P

Genetic considerations relevant to intracranial hemorrhage and brain arteriovenous malformations.

Acta neurochirurgica. Supplement

Kim H, Marchuk DA, Pawlikowska L, Chen Y, Su H, Yang GY, Young WL

Neutrophil depletion decreases VEGF-induced focal angiogenesis in the mature mouse brain.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Hao Q, Chen Y, Zhu Y, Fan Y, Palmer D, Su H, Young WL, Yang GY

Recombinant adeno-associated viral vector encoding human VEGF165 induces neomicrovessel formation in the adult mouse brain.

Frontiers in bioscience : a journal and virtual library

Shen F, Su H, Liu W, Kan YW, Young WL, Yang GY

AAV serotype-1 mediates early onset of gene expression in mouse hearts and results in better therapeutic effect.

Gene therapy

Su H, Huang Y, Takagawa J, Barcena A, Arakawa-Hoyt J, Ye J, Grossman W, Kan YW

228. AAV Mediated Hypoxia-Inducible VEGF Expression and Neovascular Formation in Ischemic Pig Myocardium.

Molecular Therapy

Hua Su, Yerem Yeghiazarians, Andrew Lee, Yu Huang, Janice Arakawa-Hoyt, Jianqin Ye, Gina Orcino, William Growssman, Yuet W. Kan

Adeno-associated viral vector delivers cardiac-specific and hypoxia-inducible VEGF expression in ischemic mouse hearts.

Proceedings of the National Academy of Sciences of the United States of America

Su H, Joho S, Huang Y, Barcena A, Arakawa-Hoyt J, Grossman W, Kan YW

Adeno-associated viral vector-mediated gene transfer of VEGF normalizes skeletal muscle oxygen tension and induces arteriogenesis in ischemic rat hindlimb.

Molecular therapy : the journal of the American Society of Gene Therapy

Chang DS, Su H, Tang GL, Brevetti LS, Sarkar R, Wang R, Kan YW, Messina LM

Adeno-associated viral vector-mediated hypoxia response element-regulated gene expression in mouse ischemic heart model.

Proceedings of the National Academy of Sciences of the United States of America

Su H, Arakawa-Hoyt J, Kan YW

Adeno-associated viral vector-mediated vascular endothelial growth factor gene transfer induces neovascular formation in ischemic heart.

Proceedings of the National Academy of Sciences of the United States of America

Su H, Lu R, Kan YW