Xuhui Liu, MD

Associate Professor
Orthopaedic Surgery
+1 415 575-0546

Dr. Liu is a well-trained and productive research scientist in the field of orthopedic surgery. He obtained his MD degree from Peking Union Medical College in China in 2001. After that, he moved to USA and received his postdoctoral research training in Orthopedic Biochemistry and Biomechanics in Baylor College of Medicine in Houston, Texas. Dr. Liu joined the Department of Orthopedic Surgery at UCSF in 2006 as a Research Biologist. He was promoted to Assistant Professor in 2008 and Associate Professor in 2015. Majority of his research focuses on the molecular and cellular mechanism of degenerative musculoskeletal diseases. The cellular and molecular mechanism of muscle atrophy and fatty degeneration is within his central research interests. He is also interested in the role of central and peripheral nerve system in regulating musculoskeletal pathophysiology. His work has been supported by NIH, VA and private charities.

Interests: Muscle atrophy and rehabilitation, Heterotopic Ossfication, ECM and MMP, Fatty infiltration, Compartment syndrome, Ischemia-reperfusion injury, Spinal cord injury

Publications: 

Defining Endogenous Mitochondrial Transfer in Muscle After Rotator Cuff Injury.

The American journal of sports medicine

Chi HM, Davies MR, Garcia SM, Montenegro C, Sharma S, Lizarraga M, Wang Z, Nuthalapati P, Kim HT, Liu X, Feeley BT

Algorithmic assessment of shoulder function using smartphone video capture and machine learning.

Scientific reports

Darevsky DM, Hu DA, Gomez FA, Davies MR, Liu X, Feeley BT

Polarized macrophages regulate fibro/adipogenic progenitor (FAP) adipogenesis through exosomes.

Stem cell research & therapy

Liu M, Ng M, Phu T, Bouchareychas L, Feeley BT, Kim HT, Raffai RL, Liu X

A Tool for Low-Cost, Quantitative Assessment of Shoulder Function Using Machine Learning.

medRxiv : the preprint server for health sciences

Darevsky DM, Hu DA, Gomez FA, Davies MR, Liu X, Feeley BT

The Role of Matrix Metalloproteinase-13 (MMP13) in TGF�/BMP Pathway Regulation of Fibro-Adipogenic Progenitor (FAP) Differentiation.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Liu M, Feeley BT, Kim HT, Liu X

A novel mouse model of hindlimb joint contracture with 3D-printed casts.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Moore LK, Lee CS, Agha O, Liu M, Zhang H, Dang ABC, Dang A, Liu X, Feeley BT

Rotator Cuff Tear Size Regulates Fibroadipogenic Progenitor Number and Gene Expression Profile in the Supraspinatus Independent of Patient Age.

The American journal of sports medicine

Davies MR, Chi H, Kaur G, Liu M, Ma CB, Kim HT, Liu X, Feeley BT

Does the Antimalarial Drug Quinine Contribute to Muscle Fibro/Adipogenic Progenitor Fibrogenesis?.

Muscles Ligaments and Tendons Journal

J.H. Jay, M. Liu, X. Liu, B.T. Feeley, C.S. Sabatini

Microenergy acoustic pulses promotes muscle regeneration through in situ activation of muscle stem cells.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Zhang H, Kim HT, Feeley BT, Lin G, Lue TF, Liu M, Banie L, Liu X

The Role of Fibro-Adipogenic Progenitors in Musculoskeletal Disease.

Muscles Ligaments and Tendons Journal

G. Kaur, M.R. Davies, X. Liu, B.T. Delioglu

Paraspinal muscle degeneration and regenerative potential in a Murine model of Lumbar Disc Injury.

North American Spine Society journal

Davies MR, Kaur G, Liu X, Alvarado FG, Nuthalapati P, Liu M, Diaz A, Lotz JC, Bailey JF, Feeley BT

Preconditioning improves muscle regeneration after ischemia-reperfusion injury.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Zhang H, Liu M, Kim HT, Feeley BT, Liu X

Brown Beige Fat Activation after Skeletal Muscle Ischemia-Reperfusion Injury.

Muscles Ligaments and Tendons Journal

M. Liu, Z. Wang, C.S. Lee, C. Nguyen, L. Lee, H.T. Kim, B.T. Feeley, X. Liu

Trichostatin A regulates fibro/adipogenic progenitor adipogenesis epigenetically and reduces rotator cuff muscle fatty infiltration.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Liu X, Liu M, Lee L, Davies M, Wang Z, Kim H, Feeley BT

Rotator cuff tear degeneration and the role of fibro-adipogenic progenitors.

Annals of the New York Academy of Sciences

Agha O, Diaz A, Davies M, Kim HT, Liu X, Feeley BT

Dried plum mitigates spinal cord injury-induced bone loss in mice.

JOR spine

Xuhui Liu, Mengyao Liu, Russell Turner, Urszula Iwaniec, Hubert Kim, Bernard Halloran

ß3-Adrenergic receptor agonist treats rotator cuff fatty infiltration by activating beige fat in mice.

Journal of shoulder and elbow surgery

Wang Z, Liu X, Liu M, Jiang K, Kajimura S, Kim H, Feeley BT

Intervertebral disc herniation effects on multifidus muscle composition and resident stem cell populations.

JOR spine

Agha O, Mueller-Immergluck A, Liu M, Zhang H, Theologis AA, Clark A, Kim HT, Liu X, Feeley BT, Bailey JF

Beige Fibro-Adipogenic Progenitors Reduce Muscle Degeneration in a Mouse Model of Delayed Repair for Massive Rotator Cuff Tears.

Journal of shoulder and elbow surgery

Carlin Lee, Mengyao Liu, Obiajulu Agha, Hubert T. Kim, Xuhui Liu, Brian T. Feeley

Beige FAPs Transplantation Improves Muscle Quality and Shoulder Function After Massive Rotator Cuff Tears.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Lee C, Liu M, Agha O, Kim HT, Feeley BT, Liu X

Rotator Cuff Fibro-Adipogenic Progenitors Demonstrate Highest Concentration, Proliferative Capacity, and Adipogenic Potential Across Muscle Groups.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Lee C, Agha O, Liu M, Davies M, Bertoy L, Kim HT, Liu X, Feeley BT

Bone morphogenetic protein signaling in rotator cuff muscle atrophy and fatty infiltration.

Muscles Ligaments and Tendons Journal

X. Liu, S. Joshi, B. Ravishankar, D. Laron, H.T. Kim, B.T. Feeley

Investigating the cellular origin of rotator cuff muscle fatty infiltration and fibrosis after injury.

Muscles Ligaments and Tendons Journal

X. Liu, A.Y. Ning, N. Chen Chang, H. Kim, R. Nissenson, L. Wang, B.T. Feeley

Knocking-out matrix metalloproteinase-13 exacerbates rotator cuff muscle fatty infiltration.

Muscles Ligaments and Tendons Journal

X. Liu, B. Ravishankar, A. Ning, M. Liu, H.T. Kim, B.T. Feeley

Muscle atrophy and fatty infiltration after an acute rotator cuff repair in a sheep model.

Muscles Ligaments and Tendons Journal

T Luan, X. Liu, J.T. Easley, B. Ravishankar, C. Puttlitz, B.T. Feeley

A Mouse Model of Delayed Rotator Cuff Repair Results in Persistent Muscle Atrophy and Fatty Infiltration.

The American journal of sports medicine

Wang Z, Liu X, Davies MR, Horne D, Kim H, Feeley BT

Muscle stem cell activation in a mouse model of rotator cuff injury.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Davies MR, Garcia S, Tamaki S, Liu X, Lee S, Jose A, Pomerantz JH, Feeley BT

Knocking-out matrix metalloproteinase-13 exacerbates rotator cuff muscle fatty infiltration.

Muscles, ligaments and tendons journal

Liu X, Ravishankar B, Ning A, Liu M, Kim HT, Feeley BT

Role of pulsed electromagnetic fields (PEMF) on tenocytes and myoblasts-potential application for treating rotator cuff tears.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Liu M, Lee C, Laron D, Zhang N, Waldorff EI, Ryaby JT, Feeley B, Liu X

Direct Measurement of Tissue Oxygenation as a Method of Diagnosis of Acute Compartment Syndrome.

Journal of orthopaedic trauma

Weick JW, Kang H, Lee L, Kuether J, Liu X, Hansen EN, Kandemir U, Rollins MD, Mok JM

Lysophosphatidic acid-induced RhoA signaling and prolonged macrophage infiltration worsens fibrosis and fatty infiltration following rotator cuff tears.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Davies MR, Lee L, Feeley BT, Kim HT, Liu X

Investigating the cellular origin of rotator cuff muscle fatty infiltration and fibrosis after injury.

Muscles, ligaments and tendons journal

Liu X, Ning AY, Chang NC, Kim H, Nissenson R, Wang L, Feeley BT

Bone morphogenetic protein signaling in rotator cuff muscle atrophy and fatty infiltration.

Muscles, ligaments and tendons journal

Liu X, Joshi S, Ravishankar B, Laron D, Kim HT, Feeley BT

Muscle atrophy and fatty infiltration after an acute rotator cuff repair in a sheep model.

Muscles, ligaments and tendons journal

Luan T, Liu X, Easley JT, Ravishankar B, Puttlitz C, Feeley BT

Effects of blockade of endogenous Gi signaling in Tie2-expressing cells on bone formation in a mouse model of heterotopic ossification.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Wang L, Carroll DO, Liu X, Roth T, Kim H, Halloran B, Nissenson RA

Rat rotator cuff muscle responds differently from hindlimb muscle to a combined tendon-nerve injury.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Davies MR, Ravishankar B, Laron D, Kim HT, Liu X, Feeley BT

Upregulation of transforming growth factor-ß signaling in a rat model of rotator cuff tears.

Journal of shoulder and elbow surgery

Liu X, Joshi SK, Ravishankar B, Laron D, Kim HT, Feeley BT

Novel mouse model of spinal cord injury-induced heterotopic ossification.

Journal of rehabilitation research and development

Kang H, Dang AB, Joshi SK, Halloran B, Nissenson R, Zhang X, Li J, Kim HT, Liu X

A novel mouse model of trauma induced heterotopic ossification.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Liu X, Kang H, Shahnazari M, Kim H, Wang L, Larm O, Adolfsson L, Nissenson R, Halloran B

Differential ubiquitin-proteasome and autophagy signaling following rotator cuff tears and suprascapular nerve injury.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Joshi SK, Kim HT, Feeley BT, Liu X

Original article Muscle extracellular matrix degradation and contractibility following tendon rupture and disuse.

Muscles, ligaments and tendons journal

Zhang Q, Joshi SK, Manzano G, Lovett DH, Kim HT, Liu X

Evaluation of cartilage degeneration in a rat model of rotator cuff tear arthropathy.

Journal of shoulder and elbow surgery

Kramer EJ, Bodendorfer BM, Laron D, Wong J, Kim HT, Liu X, Feeley BT

mTOR regulates fatty infiltration through SREBP-1 and PPAR? after a combined massive rotator cuff tear and suprascapular nerve injury in rats.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Joshi SK, Liu X, Samagh SP, Lovett DH, Bodine SC, Kim HT, Feeley BT

MRI quantification of fatty infiltration and muscle atrophy in a mouse model of rotator cuff tears.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Samagh SP, Kramer EJ, Melkus G, Laron D, Bodendorfer BM, Natsuhara K, Kim HT, Liu X, Feeley BT

A comparison of lidocaine, ropivacaine and dexamethasone toxicity on bovine tenocytes in culture.

The Journal of bone and joint surgery. British volume

Piper SL, Laron D, Manzano G, Pattnaik T, Liu X, Kim HT, Feeley BT

A mouse model of massive rotator cuff tears.

The Journal of bone and joint surgery. American volume

Liu X, Laron D, Natsuhara K, Manzano G, Kim HT, Feeley BT

Evaluation of Akt/mTOR activity in muscle atrophy after rotator cuff tears in a rat model.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Liu X, Joshi SK, Samagh SP, Dang YX, Laron D, Lovett DH, Bodine SC, Kim HT, Feeley BT

Muscle degeneration in rotator cuff tears.

Journal of shoulder and elbow surgery

Laron D, Samagh SP, Liu X, Kim HT, Feeley BT

Emerging ideas: matrix metalloproteinase-2 in muscle atrophy.

Clinical orthopaedics and related research

Liu X

A rat model of massive rotator cuff tears.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Liu X, Manzano G, Kim HT, Feeley BT

Role of AP-1 and RE-1 binding sites in matrix metalloproteinase-2 transcriptional regulation in skeletal muscle atrophy.

Biochemical and biophysical research communications

Liu X, Manzano G, Lovett DH, Kim HT

Role of gelatinases in disuse-induced skeletal muscle atrophy.

Muscle & nerve

Liu X, Lee DJ, Skittone LK, Natsuhara K, Kim HT

Pathological changes of human ligament after complete mechanical unloading.

American journal of physical medicine & rehabilitation

Chen CH, Liu X, Yeh ML, Huang MH, Zhai Q, Lowe WR, Lintner DM, Luo ZP

Mechanical strain promotes fibroblast gene expression in presence of corticosteroid.

Connective tissue research

Chen CH, Marymont JV, Huang MH, Geyer M, Luo ZP, Liu X

Force-mediated dissociation of proteoglycan aggregate in articular cartilage.

Biorheology

Liu X, Sun JQ, Heggeness MH, Yeh ML, Luo ZP

Strain-related collagen gene expression in human osteoblast-like cells.

Cell and tissue research

Liu X, Zhang X, Luo ZP

Direct measurement of the rupture force of single pair of decorin interactions.

Biochemical and biophysical research communications

Liu X, Yeh ML, Lewis JL, Luo ZP

A modified cell culture method for autologous chondrocyte transplantation.

Connective tissue research

Lee CY, Liu X, Hsu HC, Wang DY, Luo ZP

The combined regulation of estrogen and cyclic tension on fibroblast biosynthesis derived from anterior cruciate ligament.

Matrix biology : journal of the International Society for Matrix Biology

Lee CY, Liu X, Smith CL, Zhang X, Hsu HC, Wang DY, Luo ZP

Direct measurements of the compressive properties of single proteoglycan aggregates.

Biochemical and biophysical research communications

Liu X, Noble PC, Luo ZP

A method for testing compressive properties of single proteoglycan aggregates.

Biochemical and biophysical research communications

Liu X, Noble PC, Luo ZP