Xuhui Liu, MD

Associate Professor

Orthopaedic Surgery

+1 415 575-0546

Dr. Liu is a well-trained and productive research scientist in the field of orthopedic surgery. He obtained his MD degree from Peking Union Medical College in China in 2001. After that, he moved to USA and received his postdoctoral research training in Orthopedic Biochemistry and Biomechanics in Baylor College of Medicine in Houston, Texas. Dr. Liu joined the Department of Orthopedic Surgery at UCSF in 2006 as a Research Biologist. He was promoted to Assistant Professor in 2008 and Associate Professor in 2015. Majority of his research focuses on the molecular and cellular mechanism of degenerative musculoskeletal diseases. The cellular and molecular mechanism of muscle atrophy and fatty degeneration is within his central research interests. He is also interested in the role of central and peripheral nerve system in regulating musculoskeletal pathophysiology. His work has been supported by NIH, VA and private charities.

Interests: Muscle atrophy and rehabilitation, Heterotopic Ossfication, ECM and MMP, Fatty infiltration, Compartment syndrome, Ischemia-reperfusion injury, Spinal cord injury

Publications:

Poster 363: Non-Biased Analysis of ACL Tissue Shows Distinct Differences in Cell Type and Gene Expression Between Male and Female Populations.

Orthopaedic Journal of Sports Medicine

Justin Lau, Steven Garcia, Aboubacar Wague, Miguel Lizarraga, Sankalp Sharma, Grace O'Connell, Stephanie Wong, Xuhui Liu, Brian Feeley

Defining Endogenous Mitochondrial Transfer in Muscle After Rotator Cuff Injury.

The American journal of sports medicine

Chi HM, Davies MR, Garcia SM, Montenegro C, Sharma S, Lizarraga M, Wang Z, Nuthalapati P, Kim HT, Liu X, Feeley BT

Algorithmic assessment of shoulder function using smartphone video capture and machine learning.

Scientific reports

Darevsky DM, Hu DA, Gomez FA, Davies MR, Liu X, Feeley BT

Polarized macrophages regulate fibro/adipogenic progenitor (FAP) adipogenesis through exosomes.

Stem cell research & therapy

Liu M, Ng M, Phu T, Bouchareychas L, Feeley BT, Kim HT, Raffai RL, Liu X

A Tool for Low-Cost, Quantitative Assessment of Shoulder Function Using Machine Learning.

medRxiv : the preprint server for health sciences

Darevsky DM, Hu DA, Gomez FA, Davies MR, Liu X, Feeley BT

The Role of Matrix Metalloproteinase-13 (MMP13) in TGF�/BMP Pathway Regulation of Fibro-Adipogenic Progenitor (FAP) Differentiation.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Liu M, Feeley BT, Kim HT, Liu X

Muscle-Derived Beige Adipose Precursors Secrete Promyogenic Exosomes That Treat Rotator Cuff Muscle Degeneration in Mice and Are Identified in Humans by Single-Cell RNA Sequencing.

The American journal of sports medicine

Davies MR, Garcia S, Liu M, Chi H, Kim HT, Raffai RL, Liu X, Feeley BT

A novel mouse model of hindlimb joint contracture with 3D-printed casts.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Moore LK, Lee CS, Agha O, Liu M, Zhang H, Dang ABC, Dang A, Liu X, Feeley BT

Rotator Cuff Tear Size Regulates Fibroadipogenic Progenitor Number and Gene Expression Profile in the Supraspinatus Independent of Patient Age.

The American journal of sports medicine

Davies MR, Chi H, Kaur G, Liu M, Ma CB, Kim HT, Liu X, Feeley BT

Trichostatin A regulates fibro/adipogenic progenitor adipogenesis epigenetically and reduces rotator cuff muscle fatty infiltration.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Liu X, Liu M, Lee L, Davies M, Wang Z, Kim H, Feeley BT

Human Rotator Cuff Tears Have an Endogenous, Inducible Stem Cell Source Capable of Improving Muscle Quality and Function After Rotator Cuff Repair.

The American journal of sports medicine

Feeley BT, Liu M, Ma CB, Agha O, Aung M, Lee C, Liu X

Intramuscular Brown Fat Activation Decreases Muscle Atrophy and Fatty Infiltration and Improves Gait After Delayed Rotator Cuff Repair in Mice.

The American journal of sports medicine

Wang Z, Liu X, Jiang K, Kim H, Kajimura S, Feeley BT

Beige Fibro-Adipogenic Progenitors Reduce Muscle Degeneration in a Mouse Model of Delayed Repair for Massive Rotator Cuff Tears.

Journal of shoulder and elbow surgery

Carlin Lee, Mengyao Liu, Obiajulu Agha, Hubert T. Kim, Xuhui Liu, Brian T. Feeley

Beige FAPs Transplantation Improves Muscle Quality and Shoulder Function After Massive Rotator Cuff Tears.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Lee C, Liu M, Agha O, Kim HT, Feeley BT, Liu X

Rotator Cuff Fibro-Adipogenic Progenitors Demonstrate Highest Concentration, Proliferative Capacity, and Adipogenic Potential Across Muscle Groups.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Lee C, Agha O, Liu M, Davies M, Bertoy L, Kim HT, Liu X, Feeley BT

Beige fibro-adipogenic progenitor transplantation reduces muscle degeneration and improves function in a mouse model of delayed repair of rotator cuff tears.

Journal of shoulder and elbow surgery

Lee C, Liu M, Agha O, Kim HT, Liu X, Feeley BT

Role of pulsed electromagnetic fields (PEMF) on tenocytes and myoblasts-potential application for treating rotator cuff tears.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Liu M, Lee C, Laron D, Zhang N, Waldorff EI, Ryaby JT, Feeley B, Liu X

Direct Measurement of Tissue Oxygenation as a Method of Diagnosis of Acute Compartment Syndrome.

Journal of orthopaedic trauma

Weick JW, Kang H, Lee L, Kuether J, Liu X, Hansen EN, Kandemir U, Rollins MD, Mok JM

Lysophosphatidic acid-induced RhoA signaling and prolonged macrophage infiltration worsens fibrosis and fatty infiltration following rotator cuff tears.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Davies MR, Lee L, Feeley BT, Kim HT, Liu X

Investigating the cellular origin of rotator cuff muscle fatty infiltration and fibrosis after injury.

Muscles, ligaments and tendons journal

Liu X, Ning AY, Chang NC, Kim H, Nissenson R, Wang L, Feeley BT

TGF-ß Small Molecule Inhibitor SB431542 Reduces Rotator Cuff Muscle Fibrosis and Fatty Infiltration By Promoting Fibro/Adipogenic Progenitor Apoptosis.

PloS one

Davies MR, Liu X, Lee L, Laron D, Ning AY, Kim HT, Feeley BT

Bone morphogenetic protein signaling in rotator cuff muscle atrophy and fatty infiltration.

Muscles, ligaments and tendons journal

Liu X, Joshi S, Ravishankar B, Laron D, Kim HT, Feeley BT

Muscle atrophy and fatty infiltration after an acute rotator cuff repair in a sheep model.

Muscles, ligaments and tendons journal

Luan T, Liu X, Easley JT, Ravishankar B, Puttlitz C, Feeley BT

Effects of blockade of endogenous Gi signaling in Tie2-expressing cells on bone formation in a mouse model of heterotopic ossification.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Wang L, Carroll DO, Liu X, Roth T, Kim H, Halloran B, Nissenson RA

mTOR regulates fatty infiltration through SREBP-1 and PPAR? after a combined massive rotator cuff tear and suprascapular nerve injury in rats.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Joshi SK, Liu X, Samagh SP, Lovett DH, Bodine SC, Kim HT, Feeley BT

The combined regulation of estrogen and cyclic tension on fibroblast biosynthesis derived from anterior cruciate ligament.

Matrix biology : journal of the International Society for Matrix Biology

Lee CY, Liu X, Smith CL, Zhang X, Hsu HC, Wang DY, Luo ZP

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Xuhui Liu, MD