Theodore Miclau, MD

Professor
Orthopaedic Surgery
+1 628 206-8812

After graduating from Yale College and Yale University School of Medicine, Theodore Miclau III, MD, completed his residency in orthopaedic surgery at the University of North Carolina at Chapel Hill in 1994. During his residency, he spent nearly one year at the AO Research Institute in Davos, Switzerland studying fracture healing. After finishing an orthopaedic trauma fellowship at the Baylor College of Medicine in Houston, Texas in 1995, he was awarded the AO-Jack McDaniel fellowship and visited prominent trauma centers in St. Gallen, Switzerland and Berlin, Germany.

In 1996, Miclau joined the faculty of the UCSF Department of Orthopaedic Surgery as an orthopaedic traumatologist at the San Francisco General Hospital. In 2000, he received a five-year Career Development Award (K08) from the National Institutes of Health and the Musculoskeletal Transplant Foundation to study the role of angiogenesis in fracture repair; he has had funding from NIH for that program since that time. He also received the North American and American-British-Canadian traveling fellowship awards from the American Orthopaedic Association.

In 2002, Dr. Miclau became the Acting Chief of Orthopaedic Surgery at ZSFGH, and subsequently became the Chief of Orthopaedic Surgery at ZSFGH in 2004. He also became a full-tenured professor in 2004. He was named Vice Chairman and Director of Orthopaedic Trauma of the Department of Orthopaedic Surgery at UCSF in 2003. He became Director of the UCSF/SFGH Orthopaedic Trauma Institute (OTI) when it opened in 2009. The OTI is home to the largest number of trauma fellowship trained surgeons in the US and has robust, research programs that include biomechanics, molecular biology, and clinical research.

Dr. Miclau serves on many local and national committees, and editorial and grant-review panels. He is past-president of the Orthopaedic Research Society (ORS), International Combined Orthopaedic Research Societies (ICORS), and Orthopaedic Trauma Association (OTA). He is the current Steering Committee Chair of the International Orthopaedic Trauma Association, Committee Chair of the Osteosynthesis and Trauma Care Foundation’s Research Committee, Chair of the Advisory Committee of the AO Research Institute, and Trustee of the AO Foundation. He led the development of and currently organizes the Consortium of Orthopaedic Academic Traumatologists (COACT), which has the goal of enhancing the collaborative efforts of North American centers that engage in education and research in low and low-middle income countries, and the Asociación de Ciruganos Traumatólogos en las Americas (ACTUAR), which is a growing surgeon network dedicated to promoting research in Latin America. He is the course chair for the Annual San Francisco International Orthopaedic Trauma conference and other conferences nationally and internationally. His research focuses on clinical studies of musculoskeletal injury care and basic research of bone repair, which is supported by extramural grants from the US Department of Defense and the National Institutes of Health. He has published over 150 peer-reviewed research papers and 20 book chapters. He has teamed with a variety of organizations to develop research and clinical courses throughout the United States, Europe, and Latin America.

Dr. Miclau is the first recipient of the Orthopaedic Trauma Institute International Chair, which is the first-of-its-kind in the United States, and the first endowed chair at the ZSFG Department of Orthopaedic Surgery.

Interests: Cellular and Molecular Biology of Fracture Repair, orthopaedic trauma clinical research; fracture healing; cellular and molecular mechanisms; clinical trials

Publications: 

Open fractures: Current treatment perspective.

OTA international : the open access journal of orthopaedic trauma

Minehara H, Maruo A, Amadei R, Contini A, Braile A, Kelly M, Jenner L, Schemitsch GW, Schemitsch EH, Miclau T

A Shifting Paradigm: Transformation of Cartilage to Bone during Bone Repair.

Journal of dental research

Marcucio RS, Miclau T, Bahney CS

Leadership development programs for healthcare professionals in low-and middle-income countries: A systematic review.

The International journal of health planning and management

MacKechnie MC, Miclau TA, Cordero DM, Tahir P, Miclau T

Appendicular fracture and polytrauma correlate with outcome of spinal cord injury (SCI): A TRACK-SCI study.

Journal of neurotrauma

Miclau TA, Torres-Espín A, Morshed S, Morioka K, Huie JR, El Naga A, Chou A, Pascual L, Duong Fernandez X, Kuo YH, Weinstein P, Dhall S, Bresnahan JC, Beattie MS, DiGiorgio AM, Ferguson AR

Collagen X Longitudinal Fracture Biomarker Suggests Staged Fixation in Tibial Plateau Fractures Delays Rate of Endochondral Repair.

Journal of orthopaedic trauma

Working ZM, Peterson D, Lawson M, O'Hara K, Coghlan R, Provencher MT, Friess DM, Johnstone B, Miclau T, Bahney CS

Smith-Petersen Versus Watson-Jones Approach Does Not Affect Quality of Open Reduction of Femoral Neck Fracture.

Journal of orthopaedic trauma

Patterson JT, Ishii K, Tornetta P, Leighton RK, Friess DM, Jones CB, Levine A, Maclean JJ, Miclau T, Mullis BH, Obremskey WT, Ostrum RF, Reid JS, Ruder JA, Saleh A, Schmidt AH, Teague DC, Tsismenakis A, Westberg JR, Morshed S

Cost Minimization Analysis of a Teledermatology Triage System in a Managed Care Setting.

JAMA dermatology

Zakaria A, Miclau TA, Maurer T, Leslie KS, Amerson E

Open Tibial Shaft Fractures: Treatment Patterns in Latin America.

The Journal of bone and joint surgery. American volume

Albright PD, MacKechnie MC, Roberts HJ, Shearer DW, Padilla Rojas LG, Segovia J, Quintero JE, Amadei R, Baldy Dos Reis F, Miclau T, ACTUAR Open Tibia Study Group

Motivations and impact of international rotations in low- and middle-income countries for orthopaedic surgery residents: Are we on the same page?

American journal of surgery

Roberts HJ, Albright PD, Shearer DW, Won N, MacKechnie MC, Richard Coughlin R, Miclau T, Morshed S, Sabharwal S, COACT Resident Rotation Study Group

The Life of a Fracture: Biologic Progression, Healing Gone Awry, and Evaluation of Union.

JBJS reviews

Hellwinkel JE, Miclau T, Provencher MT, Bahney CS, Working ZM

A quantitative serum biomarker of circulating collagen X effectively correlates with endochondral fracture healing.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Working ZM, Morris ER, Chang JC, Coghlan RF, Johnstone B, Miclau T, Horton WA, Bahney CS

Open Reduction Is Associated With Greater Hazard of Early Reoperation After Internal Fixation of Displaced Femoral Neck Fractures in Adults 18-65 Years.

Journal of orthopaedic trauma

Patterson JT, Ishii K, Tornetta P, Leighton RK, Friess DM, Jones CB, Levine A, Maclean JJ, Miclau T, Mullis BH, Obremskey WT, Ostrum RF, Reid JS, Ruder JA, Saleh A, Schmidt AH, Teague DC, Tsismenakis A, Westberg JR, Morshed S

The global burden of musculoskeletal injury in low and lower-middle income countries: A systematic literature review.

OTA international : the open access journal of orthopaedic trauma

Cordero DM, Miclau TA, Paul AV, Morshed S, Miclau T, Martin C, Shearer DW

Knowledge deficits and barriers to performing soft-tissue coverage procedures: An analysis of participants in an orthopaedic surgical skills training course in Mexico.

OTA international : the open access journal of orthopaedic trauma

Albright PD, Mackechnie MC, Jackson JH, Chopra A, Holler JT, Flores Biard A, Padilla Rojas LG, Morshed S, Miclau T, Shearer DW, Terry MJ

Differential fracture response to traumatic brain injury suggests dominance of neuroinflammatory response in polytrauma.

Scientific reports

Morioka K, Marmor Y, Sacramento JA, Lin A, Shao T, Miclau KR, Clark DR, Beattie MS, Marcucio RS, Miclau T, Ferguson AR, Bresnahan JC, Bahney CS

Microenvironmental Regulation of Chondrocyte Plasticity in Endochondral Repair-A New Frontier for Developmental Engineering.

Frontiers in bioengineering and biotechnology

Wong SA, Rivera KO, Miclau T, Alsberg E, Marcucio RS, Bahney CS

Barriers to Clinical Research in Latin America.

Frontiers in public health

Chomsky-Higgins K, Miclau TA, Mackechnie MC, Aguilar D, Avila JR, Dos Reis FB, Balmaseda R, Barquet A, Ceballos A, Contreras F, Escalante I, Elias N, Vincenti SI, Lozano C, Medina F, Merchan G, Segovia J, Guerado E, Quintero JE, Morshed S, Bhandari M, Miclau T

Stem Cell Therapies in Orthopaedic Trauma.

Journal of orthopaedic trauma

Marcucio RS, Nauth A, Giannoudis PV, Bahney C, Piuzzi NS, Muschler G, Miclau T

The multifaceted role of the vasculature in endochondral fracture repair.

Frontiers in endocrinology

Bahney CS, Hu DP, Miclau T, Marcucio RS

Modulation of macrophage activity during fracture repair has differential effects in young adult and elderly mice.

Journal of orthopaedic trauma

Slade Shantz JA, Yu YY, Andres W, Miclau T, Marcucio R

Status of road safety and injury burden: North America.

Journal of orthopaedic trauma

Shearer D, Morshed S, Miclau T

Acute complications of patients with pelvic fractures after pelvic angiographic embolization.

Clinical orthopaedics and related research

Matityahu A, Marmor M, Elson JK, Lieber C, Rogalski G, Lin C, Belaye T, Miclau T, Kandemir U

Use of osteobiologics in the management of osteoporotic fractures.

Journal of orthopaedic trauma

Nauth A, Miclau T, Bhandari M, Schemitsch EH

Rejuvenation of the inflammatory system stimulates fracture repair in aged mice.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Xing Z, Lu C, Hu D, Miclau T, Marcucio RS

Action of IL-1beta during fracture healing.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Lange J, Sapozhnikova A, Lu C, Hu D, Li X, Miclau T, Marcucio RS

Gene therapy for fracture healing.

Journal of orthopaedic trauma

Nauth A, Miclau T, Li R, Schemitsch EH

Delayed internal fixation of femoral shaft fracture reduces mortality among patients with multisystem trauma.

The Journal of bone and joint surgery. American volume

Morshed S, Miclau T, Bembom O, Cohen M, Knudson MM, Colford JM

Qualitative and quantitative assessment of bone fragility and fracture healing using conventional radiography and advanced imaging technologies--focus on wrist fracture.

Journal of orthopaedic trauma

Firoozabadi R, Morshed S, Engelke K, Prevrhal S, Fierlinger A, Miclau T, Genant HK

Variability in the assessment of fracture-healing in orthopaedic trauma studies.

The Journal of bone and joint surgery. American volume

Corrales LA, Morshed S, Bhandari M, Miclau T

Outcome assessment in clinical trials of fracture-healing.

The Journal of bone and joint surgery. American volume

Morshed S, Corrales L, Genant H, Miclau T

What's new in orthopaedic trauma.

The Journal of bone and joint surgery. American volume

Cole PA, Miclau T, Bhandari M

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