
Adjunct Professor & Lecturer
Medicine
+1 415 575-0551
Major programs in Dr. Halloran's laboratory include stem cell aging using animal models to study the effects of aging on stem cells and bone. Projects include work with natural products from fruits for the treatment of osteoporosis, development of orthopedic stem cell-based devices to facilitate spine fusion and bone healing. Students and postdoctoral fellows are encouraged to work collaboratively with other faculty in the Departments of Medicine, Bioengineering and Orthopedics.
Interests: Aging, bone, nutrition, skeletal mechanical loading, heterotopic ossification, orthopedic device development, bone regeneration, orthopedic device development.
Publications
Locally Delivered Ascorbic Acid and β-Glycerophosphate Augment Local Bone Graft in a Murine Model of 2-Level Posterior Spinal Fusion.
International journal of spine surgery
Dietary countermeasure mitigates simulated spaceflight-induced osteopenia in mice.
Scientific reports
Claude D Arnaud, Jr, MD (1929–2016): ASBMR Loses a Founding Father.
Journal of Bone and Mineral Research
Dietary dried plum increases bone mass, suppresses proinflammatory cytokines and promotes attainment of peak bone mass in male mice.
The Journal of nutritional biochemistry
Dried plum diet protects from bone loss caused by ionizing radiation.
Scientific reports
Dietary Dried Plum Increases Peak Bone Mass.
Nutritional Influences on Bone Health
Effects of blockade of endogenous Gi signaling in Tie2-expressing cells on bone formation in a mouse model of heterotopic ossification.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Novel mouse model of spinal cord injury-induced heterotopic ossification.
Journal of rehabilitation research and development
Effects of dried plum supplementation on bone metabolism in adult C57BL/6 male mice.
Calcified tissue international
A novel mouse model of trauma induced heterotopic ossification.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
CXCL12/CXCR4 signaling in the osteoblast regulates the mesenchymal stem cell and osteoclast lineage populations.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Simulated spaceflight produces a rapid and sustained loss of osteoprogenitors and an acute but transitory rise of osteoclast precursors in two genetic strains of mice.
American journal of physiology. Endocrinology and metabolism
Early response of bone marrow osteoprogenitors to skeletal unloading and sclerostin antibody.
Calcified tissue international
Skeletal unloading-induced insulin-like growth factor 1 (IGF-1) nonresponsiveness is not shared by platelet-derived growth factor: the selective role of integrins in IGF-1 signaling.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Comparative Study of Dried Fruits and Their Ability to Restore Bone Microarchitecture in Osteopenic C57BL/6 Mice.
The FASEB Journal
Dietary dried plum increases bone mass in adult and aged male mice.
The Journal of nutrition
Gs G protein-coupled receptor signaling in osteoblasts elicits age-dependent effects on bone formation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass.
Proceedings of the National Academy of Sciences of the United States of America
Integrin Regulation of the IGF-I Receptor in Bone, and the Response to Load.
Clinical Reviews in Bone and Mineral Metabolism
Conditional expression of a Gi-coupled receptor in osteoblasts results in trabecular osteopenia.
Endocrinology
IGF-I receptor is required for the anabolic actions of parathyroid hormone on bone.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Aging impairs IGF-I receptor activation and induces skeletal resistance to IGF-I.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Insulin-like growth factor I stimulates recovery of bone lost after a period of skeletal unloading.
Journal of applied physiology (Bethesda, Md. : 1985)
Role of IGF-I signaling in regulating osteoclastogenesis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Effects of in vitro bone formation on the mechanical properties of a trabeculated hydroxyapatite bone substitute.
Journal of biomedical materials research. Part A
Gender differences in the response of CD-1 mouse bone to parathyroid hormone: potential role of IGF-I.
The Journal of endocrinology
IGF-I enhances bone recovery after 2 weeks of unloading.
The FASEB Journal
The Role of IGF-I Signaling in Regulating Osteoclastogenesis.
The FASEB Journal
Metabolic acidosis reverses the increase in serum 1,25(OH)2D in phosphorus-restricted normal men.
AJP Endocrinology and Metabolism
Aging increases stromal/osteoblastic cell-induced osteoclastogenesis and alters the osteoclast precursor pool in the mouse.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Hyaluronan increases RANKL expression in bone marrow stromal cells through CD44.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Skeletal unloading induces resistance to insulin-like growth factor-I (IGF-I) by inhibiting activation of the IGF-I signaling pathways.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
PTH differentially regulates expression of RANKL and OPG.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
bFGF administration lowers the phosphate threshold for mineralization in bone marrow stromal cells.
Calcified tissue international
The impact of skeletal unloading on bone formation.
Gravitational and space biology bulletin : publication of the American Society for Gravitational and Space Biology
Expression of RANKL and OPG correlates with age-related bone loss in male C57BL/6 mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Mechanical and chemical characteristics of mineral produced by basic fibroblast growth factor-treated bone marrow stromal cells in vitro.
Tissue engineering
Insulin-like growth factor I is required for the anabolic actions of parathyroid hormone on mouse bone.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Changes in bone structure and mass with advancing age in the male C57BL/6J mouse.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Dehydroepiandrosterone supplementation and bone turnover in middle-aged to elderly men.
The Journal of clinical endocrinology and metabolism
Parathyroid gland volume increases with postmaturational aging in the rat.
American journal of physiology. Endocrinology and metabolism
The skeletal structure of insulin-like growth factor I-deficient mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Spaceflight alters bone mechanics and modeling drifts in growing rats.
Aviation, space, and environmental medicine
Long-term measurement of bone strain in vivo: the rat tibia.
Journal of biomedical materials research
Osteoblasts respond to pulsatile fluid flow with short-term increases in PGE(2) but no change in mineralization.
Journal of applied physiology (Bethesda, Md. : 1985)
Animal housing influences the response of bone to spaceflight in juvenile rats.
Journal of applied physiology (Bethesda, Md. : 1985)
Bone and hormonal changes induced by skeletal unloading in the mature male rat.
The American journal of physiology
Chapter 10 Age-Related Changes in Mineral Metabolism.
Osteoporosis in Men
Skeletal unloading causes resistance of osteoprogenitor cells to parathyroid hormone and to insulin-like growth factor-I.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
The response of bone to unloading.
Journal of bone and mineral metabolism
Lack of effect of spaceflight on bone mass and bone formation in group-housed rats.
Journal of applied physiology (Bethesda, Md. : 1985)
A longitudinal study of calcium homeostasis during human pregnancy and lactation and after resumption of menses.
The American journal of clinical nutrition
Skeletal unloading inhibits the in vitro proliferation and differentiation of rat osteoprogenitor cells.
The American journal of physiology
Regional responsiveness of the tibia to intermittent administration of parathyroid hormone as affected by skeletal unloading.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Spaceflight and the skeleton: lessons for the earthbound.
Gravitational and space biology bulletin : publication of the American Society for Gravitational and Space Biology
Aging alters calcium regulation of serum concentration of parathyroid hormone in healthy men.
The American journal of physiology
Space flight and the skeleton: lessons for the earthbound.
The Endocrinologist
Aging and renal responsiveness to parathyroid hormone in healthy men.
The Journal of Clinical Endocrinology & Metabolism
Aging and renal responsiveness to parathyroid hormone in healthy men.
The Journal of clinical endocrinology and metabolism
Effect of aging on the metabolism of phosphorus and 1,25-dihydroxyvitamin D in healthy men.
The American journal of physiology
Skeletal unloading induces selective resistance to the anabolic actions of growth hormone on bone.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
The molecular response of bone to growth hormone during skeletal unloading: regional differences.
Endocrinology
The molecular response of bone to growth hormone during skeletal unloading: regional differences.
Endocrinology
Altered skeletal pattern of gene expression in response to spaceflight and hindlimb elevation.
The American journal of physiology
Alendronate increases skeletal mass of growing rats during unloading by inhibiting resorption of calcified cartilage.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Skeletal unloading induces resistance to insulin-like growth factor I.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Expression of the genes for insulin-like growth factors and their receptors in bone during skeletal growth.
The American journal of physiology
Impact of skeletal unloading on bone formation: role of systemic and local factors.
Acta astronautica
Production of 1,25 dihydroxyvitamin D3 by perfused pig skin.
The Journal of investigative dermatology
Cellular growth and differentiation during embryogenesis and fetal development. The role of vitamin D.
Advances in experimental medicine and biology
Alcohol-induced bone disease: relationship to age and parathyroid hormone levels.
Alcoholism, clinical and experimental research
Skeletal unloading decreases production of 1,25-dihydroxyvitamin D.
The American journal of physiology
Elevated 1,25-dihydroxyvitamin D levels in patients with chronic obstructive pulmonary disease treated with prednisone.
The Journal of clinical endocrinology and metabolism
Metabolic acidosis reverses the increase in serum 1,25(OH)2D in phosphorus-restricted normal men.
The American journal of physiology
Progestin antagonism of estrogen stimulated 1,25-dihydroxyvitamin D levels.
The Journal of clinical endocrinology and metabolism
Kinetics of 1,25-dihydroxyvitamin D metabolism in the aging rat.
The American journal of physiology
Effect of aging on the circadian rhythm in serum concentration of phosphorus in healthy men.
Bone and mineral
1,25-Dihydroxyvitamin D3 and muscle strength in the elderly: a randomized controlled trial.
The Journal of clinical endocrinology and metabolism
Different responses of trabecular and cortical bone to 1,25(OH)2D3 infusion.
The American journal of physiology
Production and metabolic clearance of 1,25-dihydroxyvitamin D in men: effect of advancing age.
The Journal of clinical endocrinology and metabolism
Bone response to normal weight bearing after a period of skeletal unloading.
The American journal of physiology
Is 1,25-dihydroxyvitamin D required for reproduction?
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
Physiologic regulation of the serum concentration of 1,25-dihydroxyvitamin D by phosphorus in normal men.
The Journal of clinical investigation
Vitamin D kinetics in vivo: effect of 1,25-dihydroxyvitamin D administration.
The American journal of physiology
Glucocorticoids and inhibition of bone formation induced by skeletal unloading.
The American journal of physiology
Dietary phosphorus and 1,25-dihydroxyvitamin D metabolism: influence of insulin-like growth factor I.
Endocrinology
Dietary intake of phosphorus modulates the circadian rhythm in serum concentration of phosphorus. Implications for the renal production of 1,25-dihydroxyvitamin D.
The Journal of clinical investigation
The effect of vitamin D status on cutaneous sterologenesis in vivo and in vitro.
Biochimica et biophysica acta
Chronic administration of 1,25-dihydroxyvitamin D3: increased bone but impaired mineralization.
Endocrinology
Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein.
The Journal of clinical endocrinology and metabolism
Chronic 1,25-dihydroxyvitamin D3 administration in the rat reduces the serum concentration of 25-hydroxyvitamin D by increasing metabolic clearance rate.
The Journal of clinical investigation
Free 25-hydroxyvitamin D levels are normal in subjects with liver disease and reduced total 25-hydroxyvitamin D levels.
The Journal of clinical investigation
Skeletal response to dietary calcium in a rat model simulating weightlessness.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
The role of 1,25-dihydroxyvitamin D in the inhibition of bone formation induced by skeletal unloading.
Endocrinology
Oral intake of phosphorus can determine the serum concentration of 1,25-dihydroxyvitamin D by determining its production rate in humans.
The Journal of clinical investigation
Effect of simulated weightlessness and chronic 1,25-dihydroxyvitamin D administration on bone metabolism.
The Physiologist
Long-term control of plasma calcitriol concentration in dogs and humans. Dominant role of plasma calcium concentration in experimental hyperparathyroidism.
The Journal of clinical investigation
Bone disease in alcohol abuse.
Annals of internal medicine
Serum concentration of 1,25-dihydroxyvitamin D in the human: diurnal variation.
The Journal of clinical endocrinology and metabolism
Measurement of 25,26-dihydroxyvitamin D: importance of the configuration of the C-25 hydroxyl group.
Biochemistry
Free 1,25-dihydroxyvitamin D levels in serum from normal subjects, pregnant subjects, and subjects with liver disease.
The Journal of clinical investigation
Plasma vitamin D metabolite concentrations in chronic renal failure: effect of oral administration of 25-hydroxyvitamin D3.
The Journal of clinical endocrinology and metabolism
Separation of isotopically labeled vitamin D metabolites by high-performance liquid chromatography.
Journal of chromatography
Effect of dietary phosphorus on circulating concentrations of 1,25-dihydroxyvitamin D and immunoreactive parathyroid hormone in children with moderate renal insufficiency.
The Journal of clinical investigation
Effect of age and dietary calcium on renal 25(OH)D metabolism, serum 1,25(OH)2D, and PTH.
The American journal of physiology
Probenecid inhibits the secretion of nephrogenous adenosine 3',5'-monophosphate in normal man.
The Journal of clinical endocrinology and metabolism
Studies on the role of vitamin D in early skeletal development, mineralization, and growth in rats.
Calcified tissue international
Responsiveness of vitamin D-deficient fetal rat limb bones to parathyroid hormone in culture.
The American journal of physiology
Radioimmunoassay of the Vitamin D Metabolites.
Assay of Calcium-regulating Hormones
Role of vitamin D in maternal skeletal changes during pregnancy and lactation: a histomorphometric study.
Calcified tissue international
Molecular events involved in 1,25-dihydroxyvitamin D3 stimulation of intestinal calcium transport.
Federation proceedings
Appearance of the intestinal cytosolic receptor for 1,25-dihydroxyvitamin D3 during neonatal development in the rat.
The Journal of biological chemistry
An examination of the importance of 24-hydroxylation to the function of vitamin D during early development.
Endocrinology
Effect of vitamin D deficiency on skeletal development during early growth in the rat.
Archives of biochemistry and biophysics
Intestinal calcium transport: evidence for two distinct mechanisms of action of 1,25-dihydroxyvitamin D3.
Archives of biochemistry and biophysics
Studies on the role of 24-hydroxylation of vitamin D in the mineralization of cartilage and bone of vitamin D-deficient rats.
Calcified tissue international
Calcium transport in small intestine during early development: role of vitamin D.
The American journal of physiology
Effect of vitamin D deficiency on fertility and reproductive capacity in the female rat.
The Journal of nutrition
Calcium transport in small intestine during pregnancy and lactation.
The American journal of physiology
(Ca2+ + Mg2+)-ATPase and calmodulin activity of rat red blood cells: lack of dependence on vitamin D.
FEBS letters
Vitamin D metabolism during pregnancy and lactation in the rat.
Proceedings of the National Academy of Sciences of the United States of America
In vitro production of 1,25-dihydroxyvitamin D3 by rat placental tissue.
Proceedings of the National Academy of Sciences of the United States of America
Vitamin D deficiency and reproduction in rats.
Science (New York, N.Y.)
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