Roland Krug, PhD

Associate Professor
Radiology & Biomedical Imaging
[email protected]
+1 415 353-4945

Roland Krug, PhD, has been at UCSF since 2003. Dr. Krug’s research interests include applying novel Magnetic Resonance Imaging and Spectroscopy tools to advance diagnosis of several musculoskeletal conditions with the ultimate goal to improve the quality of life of patients. He has a strong focus on identifying mechanisms that are responsible for low back pain as well as using novel tools such as MR guided high intensity focused ultrasound to treat this condition.

As a principal investigator, Dr. Krug has received substantial support from NIH including two R01, and a UH2/UH3. He is also a director of an U19 grant from the HEAL initiative to fight opioid addiction with a volume of 30 Million USD. Dr. Krug has more than 70 peer-reviewed articles published in the highest ranking journals in the field and serves as a reviewer for more than 15 scientific journals. He reviews grants for NIH as well as the German, Austrian, Dutch, and British National Institutes. He also teaches a class on MR pulse programming in the departmental master program.

Interests: Quantitative Bone and Marrow Imaging at the Hip, Muscle Imaging, Metal MRI, MR guided High Intensity Focused Ultrasound (MRgHIFU)

Publications: 

Magnetic Resonance Assessment of Bone Quality in Metabolic Bone Diseases.

Seminars in musculoskeletal radiology

Sollmann N, Dieckmeyer M, Carballido-Gamio J, Van AT, Karampinos DC, Feuerriegel GC, Foreman SC, Gersing AS, Krug R, Baum T, Kirschke JS

Thresholding approaches for estimating paraspinal muscle fat infiltration using T1- and T2-weighted MRI: Comparative analysis using water-fat MRI.

JOR spine

Ornowski J, Dziesinski L, Hess M, Krug R, Fortin M, Torres-Espin A, Majumdar S, Pedoia V, Bonnheim NB, Bailey JF

Magnetic resonance imaging of the lumbar spine-recommendations for acquisition and image evaluation from the BACPAC Spine Imaging Working Group.

Pain medicine (Malden, Mass.)

Sollmann N, Fields AJ, O'Neill C, Nardo L, Majumdar S, Chin CT, Tosun D, Han M, Vu AT, Ozhinsky E, Shah LM, Harris RE, Lobo R, Anderst W, Herzog R, Psioda MA, Standaert CJ, Price RT, Lotz JC, Link TM, Krug R

The Back Pain Consortium (BACPAC) Research Program: Structure, Research Priorities, and Methods.

Pain medicine (Malden, Mass.)

Mauck MC, Lotz J, Psioda MA, Carey TS, Clauw DJ, Majumdar S, Marras WS, Vo N, Aylward A, Hoffmeyer A, Zheng P, Ivanova A, McCumber M, Carson C, Anstrom KJ, Bowden AE, Dalton D, Derr L, Dufour J, Fields AJ, Fritz J, Hassett AL, Harte SE, Hue TF, Krug R, Loggia ML, Mageswaran P, McLean SA, Mitchell UH, O'Neill C, Pedoia V, Quirk DA, Rhon DI, Rieke V, Shah L, Sowa G, Spiegel B, Wasan AD, Wey HM, LaVange L

Deep-learning-based biomarker of spinal cartilage endplate health using ultra-short echo time magnetic resonance imaging.

Quantitative imaging in medicine and surgery

Bonnheim NB, Wang L, Lazar AA, Chachad R, Zhou J, Guo X, O'Neill C, Castellanos J, Du J, Jang H, Krug R, Fields AJ

ISSLS Prize in Bioengineering Science 2023: Age- and sex-related differences in lumbar intervertebral disc degeneration between patients with chronic low back pain and asymptomatic controls.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Bonnheim NB, Lazar AA, Kumar A, Akkaya Z, Zhou J, Guo X, O'Neill C, Link TM, Lotz JC, Krug R, Fields AJ

Influence of patient-specific factors when comparing multifidus fat infiltration between chronic low back pain patients and asymptomatic controls.

JOR spine

Ballatori AM, Shahrestani S, Nyayapati P, Agarwal V, Krug R, Han M, Fields AJ, O'Neill C, Demir-Deviren S, Lotz JC, Bailey JF

Spatial distribution of fat infiltration within the paraspinal muscles: implications for chronic low back pain.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Khattab K, Dziesinski LK, Crawford R, Ballatori A, Nyayapati P, Krug R, Fields A, O'Neill CW, Lotz JC, Bailey JF

Imaging of the Osteoporotic Spine - Quantitative Approaches in Diagnostics and for the Prediction of the Individual Fracture Risk.

RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin

Sollmann N, Kirschke JS, Kronthaler S, Boehm C, Dieckmeyer M, Vogele D, Kloth C, Lisson CG, Carballido-Gamio J, Link TM, Karampinos DC, Karupppasamy S, Beer M, Krug R, Baum T

The contributions of cartilage endplate composition and vertebral bone marrow fat to intervertebral disc degeneration in patients with chronic low back pain.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Bonnheim NB, Wang L, Lazar AA, Zhou J, Chachad R, Sollmann N, Guo X, Iriondo C, O'Neill C, Lotz JC, Link TM, Krug R, Fields AJ

Using hierarchical unsupervised learning to integrate and reduce multi-level and multi-paraspinal muscle MRI data in relation to low back pain.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Torres-Espin A, Keller A, Johnson GTA, Fields AJ, Krug R, Ferguson AR, Hargens AR, O'Neill CW, Lotz JC, Bailey JF

Paraspinal Muscle in Chronic Low Back Pain: Comparison Between Standard Parameters and Chemical Shift Encoding-Based Water-Fat MRI.

Journal of magnetic resonance imaging : JMRI

Sollmann N, Bonnheim NB, Joseph GB, Chachad R, Zhou J, Akkaya Z, Pirmoazen AM, Bailey JF, Guo X, Lazar AA, Link TM, Fields AJ, Krug R

CT-like MRI: a qualitative assessment of ZTE sequences for knee osseous abnormalities.

Skeletal radiology

Bharadwaj UU, Coy A, Motamedi D, Sun D, Joseph GB, Krug R, Link TM

Texture Analysis Using CT and Chemical Shift Encoding-Based Water-Fat MRI Can Improve Differentiation Between Patients With and Without Osteoporotic Vertebral Fractures.

Frontiers in endocrinology

Sollmann N, Becherucci EA, Boehm C, Husseini ME, Ruschke S, Burian E, Kirschke JS, Link TM, Subburaj K, Karampinos DC, Krug R, Baum T, Dieckmeyer M

Measurement of vertebral endplate bone marrow lesion (Modic change) composition with water-fat MRI and relationship to patient-reported outcome measures.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Fields AJ, Ballatori A, Han M, Bailey JF, McCormick ZL, O'Neill CW, Demir-Deviren S, Krug R, Lotz JC

Automatic Vertebral Body Segmentation Based on Deep Learning of Dixon Images for Bone Marrow Fat Fraction Quantification.

Frontiers in endocrinology

Zhou J, Damasceno PF, Chachad R, Cheung JR, Ballatori A, Lotz JC, Lazar AA, Link TM, Fields AJ, Krug R

Evaluation of human cartilage endplate composition using MRI: Spatial variation, association with adjacent disc degeneration, and in vivo repeatability.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Wang L, Han M, Wong J, Zheng P, Lazar AA, Krug R, Fields AJ

MRI-Based Quantitative Osteoporosis Imaging at the Spine and Femur.

Journal of magnetic resonance imaging : JMRI

Sollmann N, Löffler MT, Kronthaler S, Böhm C, Dieckmeyer M, Ruschke S, Kirschke JS, Carballido-Gamio J, Karampinos DC, Krug R, Baum T

Serum Biomarkers for Connective Tissue and Basement Membrane Remodeling are Associated with Vertebral Endplate Bone Marrow Lesions as Seen on MRI (Modic Changes).

International journal of molecular sciences

Dudli S, Ballatori A, Bay-Jensen AC, McCormick ZL, O'Neill CW, Demir-Deviren S, Krug R, Heggli I, Juengel A, Karppinen J, Brunner F, Farshad M, Distler O, Lotz JC, Fields AJ

Factors associated with bone microstructural alterations assessed by HR-pQCT in long-term HIV-infected individuals.

Bone

Foreman SC, Wu PH, Kuang R, John MD, Tien PC, Link TM, Krug R, Kazakia GJ

Effects of a 12-Month Supervised, Community-Based, Multimodal Exercise Program Followed by a 6-Month Research-to-Practice Transition on Bone Mineral Density, Trabecular Microarchitecture, and Physical Function in Older Adults: A Randomized Controlled Tria

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Daly RM, Gianoudis J, Kersh ME, Bailey CA, Ebeling PR, Krug R, Nowson CA, Hill K, Sanders KM

Patients with Type 2 Diabetes Exhibit a More Mineralized Deep Cartilage Layer Compared with Nondiabetic Controls: A Pilot Study.

Cartilage

Foreman SC, Ashmeik W, Baal JD, Han M, Bahroos E, von Schacky CE, Carl M, Krug R, Joseph GB, Link TM

Measuring and reporting of vertebral endplate bone marrow lesions as seen on MRI (Modic changes): recommendations from the ISSLS Degenerative Spinal Phenotypes Group.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Fields AJ, Battié MC, Herzog RJ, Jarvik JG, Krug R, Link TM, Lotz JC, O'Neill CW, Sharma A, ISSLS Degenerative Spinal Phenotypes Group

The Relationship Between Endplate Pathology and Patient-reported Symptoms for Chronic Low Back Pain Depends on Lumbar Paraspinal Muscle Quality.

Spine

Bailey JF, Fields AJ, Ballatori A, Cohen D, Jain D, Coughlin D, O'Neill C, McCormick Z, Han M, Krug R, Demir-Deviren S, Lotz JC

Cortical bone vessel identification and quantification on contrast-enhanced MR images.

Quantitative imaging in medicine and surgery

Wu PH, Gibbons M, Foreman SC, Carballido-Gamio J, Han M, Krug R, Liu J, Link TM, Kazakia GJ

Associations between vertebral body fat fraction and intervertebral disc biochemical composition as assessed by quantitative MRI.

Journal of magnetic resonance imaging : JMRI

Krug R, Joseph GB, Han M, Fields A, Cheung J, Mundada M, Bailey J, Rochette A, Ballatori A, McCulloch CE, McCormick Z, O'Neill C, Link TM, Lotz J

Adaptation of the proximal humerus to physical activity: A within-subject controlled study in baseball players.

Bone

Warden SJ, Carballido-Gamio J, Avin KG, Kersh ME, Fuchs RK, Krug R, Bice RJ

Cartilage Endplate Thickness Variation Measured by Ultrashort Echo-Time MRI Is Associated With Adjacent Disc Degeneration.

Spine

Berg-Johansen B, Han M, Fields AJ, Liebenberg EC, Lim BJ, Larson PE, Gunduz-Demir C, Kazakia GJ, Krug R, Lotz JC

Quantification of 89 Zr-Iron oxide nanoparticle biodistribution using PET-MR and ultrashort TE sequences.

Journal of magnetic resonance imaging : JMRI

Jordan CD, Han M, Kondapavulur S, Vera DB, Neumann KD, Moore T, Stillson C, Krug R, Behr S, Seo Y, VanBrocklin HF, Larson PEZ, Wilson M, Martin AJ, Hetts SW

Trabecular bone microstructure is impaired in the proximal femur of human immunodeficiency virus-infected men with normal bone mineral density.

Quantitative imaging in medicine and surgery

Kazakia GJ, Carballido-Gamio J, Lai A, Nardo L, Facchetti L, Pasco C, Zhang CA, Han M, Parrott AH, Tien P, Krug R

A Prospective, Quantitative Evaluation of Fatty Infiltration Before and After Rotator Cuff Repair.

Orthopaedic Journal of Sports Medicine

Lansdown DA, Lee S, Sam C, Krug R, Feeley BT, Ma CB

Quantitative MRI and spectroscopy of bone marrow.

Journal of magnetic resonance imaging : JMRI

Karampinos DC, Ruschke S, Dieckmeyer M, Diefenbach M, Franz D, Gersing AS, Krug R, Baum T

Effect of Sonication Duration and Power on Ablation Depth During MR-Guided Focused Ultrasound of Bone.

Journal of magnetic resonance imaging : JMRI

Bucknor MD, Ozhinsky E, Shah R, Krug R, Rieke V

T2-based temperature monitoring in bone marrow for MR-guided focused ultrasound.

Journal of therapeutic ultrasound

Ozhinsky E, Han M, Bucknor M, Krug R, Rieke V

Evaluation of MRI protocols for the assessment of lumbar facet joints after MR-guided focused ultrasound treatment.

Journal of therapeutic ultrasound

Krug R, Do L, Rieke V, Wilson MW, Saeed M

Quantitative assessment of morphology, T1?, and T2 of shoulder cartilage using MRI.

European radiology

Nardo L, Carballido-Gamio J, Tang S, Lai A, Krug R

Ultrashort echo time and zero echo time MRI at 7T.

Magma (New York, N.Y.)

Larson PE, Han M, Krug R, Jakary A, Nelson SJ, Vigneron DB, Henry RG, McKinnon G, Kelley DA

Erratum to: Metal artifact suppression at the hip: diagnostic performance at 3.0 T versus 1.5 Tesla.

Skeletal radiology

Nardo L, Han M, Kretzschmar M, Guindani M, Koch K, Vail T, Krug R, Link TM

Quantifying temperature-dependent T1 changes in cortical bone using ultrashort echo-time MRI.

Magnetic resonance in medicine

Han M, Rieke V, Scott SJ, Ozhinsky E, Salgaonkar VA, Jones PD, Larson PE, Diederich CJ, Krug R

Improved differentiation between knees with cartilage lesions and controls using 7T relaxation time mapping.

Journal of Orthopaedic Translation

Wyatt C, Guha A, Venkatachari A, Li X, Krug R, Kelley DE, Link T, Majumdar S

Cardiac MR imaging: current status and future direction.

Cardiovascular diagnosis and therapy

Saeed M, Van TA, Krug R, Hetts SW, Wilson MW

Metal artifact suppression at the hip: diagnostic performance at 3.0 T versus 1.5 Tesla.

Skeletal radiology

Nardo L, Han M, Kretzschmar M, Kretschmar M, Guindani M, Koch K, Vail T, Krug R, Link TM

MRI monitoring of function, perfusion and viability in microembolized moderately ischemic myocardium.

The international journal of cardiovascular imaging

Do L, Wilson MW, Krug R, Hetts SW, Saeed M

Magnetic resonance rotator cuff fat fraction and its relationship with tendon tear severity and subject characteristics.

Journal of shoulder and elbow surgery

Lee S, Lucas RM, Lansdown DA, Nardo L, Lai A, Link TM, Krug R, Ma CB

Metal artefact suppression at 3 T MRI: comparison of MAVRIC-SL with conventional fast spin echo sequences in patients with Hip joint arthroplasty.

European radiology

Kretzschmar M, Nardo L, Han MM, Heilmeier U, Sam C, Joseph GB, Koch KM, Krug R, Link TM

Validation of bone marrow fat quantification in the presence of trabecular bone using MRI.

Journal of magnetic resonance imaging : JMRI

Gee CS, Nguyen JT, Marquez CJ, Heunis J, Lai A, Wyatt C, Han M, Kazakia G, Burghardt AJ, Karampinos DC, Carballido-Gamio J, Krug R

In vitro assessment of knee MRI in the presence of metal implants comparing MAVRIC-SL and conventional fast spin echo sequences at 1.5 and 3 T field strength.

Journal of magnetic resonance imaging : JMRI

Liebl H, Heilmeier U, Lee S, Nardo L, Patsch J, Schuppert C, Han M, Rondak IC, Banerjee S, Koch K, Link TM, Krug R

Bone marrow fat quantification in the presence of trabecular bone: initial comparison between water-fat imaging and single-voxel MRS.

Magnetic resonance in medicine

Karampinos DC, Melkus G, Baum T, Bauer JS, Rummeny EJ, Krug R

Quantitative assessment of fat infiltration in the rotator cuff muscles using water-fat MRI.

Journal of magnetic resonance imaging : JMRI

Nardo L, Karampinos DC, Lansdown DA, Carballido-Gamio J, Lee S, Maroldi R, Ma CB, Link TM, Krug R

Ultrashort echo time MRI of cortical bone at 7 tesla field strength: a feasibility study.

Journal of magnetic resonance imaging : JMRI

Krug R, Larson PE, Wang C, Burghardt AJ, Kelley DA, Link TM, Zhang X, Vigneron DB, Majumdar S

Generation of an atlas of the proximal femur and its application to trabecular bone analysis.

Magnetic resonance in medicine

Carballido-Gamio J, Folkesson J, Karampinos DC, Baum T, Link TM, Majumdar S, Krug R

Longitudinal evaluation of the effects of alendronate on MRI bone microarchitecture in postmenopausal osteopenic women.

Bone

Folkesson J, Goldenstein J, Carballido-Gamio J, Kazakia G, Burghardt AJ, Rodriguez A, Krug R, de Papp AE, Link TM, Majumdar S

High-resolution imaging techniques for the assessment of osteoporosis.

Radiologic clinics of North America

Krug R, Burghardt AJ, Majumdar S, Link TM

Isotropic 3-dimensional fast spin echo imaging versus standard 2-dimensional imaging at 3.0 T of the knee: artificial cartilage and meniscal lesions in a porcine model.

Journal of computer assisted tomography

Ristow O, Stehling C, Krug R, Steinbach L, Sabo G, Ambekar A, Huber M, Link TM

Imaging of the musculoskeletal system in vivo using ultra-high field magnetic resonance at 7 T.

Investigative radiology

Krug R, Stehling C, Kelley DA, Majumdar S, Link TM

7T human spine imaging arrays with adjustable inductive decoupling.

IEEE transactions on bio-medical engineering

Wu B, Wang C, Krug R, Kelley DA, Xu D, Pang Y, Banerjee S, Vigneron DB, Nelson SJ, Majumdar S, Zhang X

MRI of the spine: image quality and normal-neoplastic bone marrow contrast at 3 T versus 1.5 T.

AJR. American journal of roentgenology

Zhao J, Krug R, Xu D, Lu Y, Link TM

Geodesic topological analysis of trabecular bone microarchitecture from high-spatial resolution magnetic resonance images.

Magnetic resonance in medicine

Carballido-Gamio J, Krug R, Huber MB, Hyun B, Eckstein F, Majumdar S, Link TM

Isotropic 3D fast spin-echo imaging versus standard 2D imaging at 3.0 T of the knee--image quality and diagnostic performance.

European radiology

Ristow O, Steinbach L, Sabo G, Krug R, Huber M, Rauscher I, Ma B, Link TM

Advances of 3T MR imaging in visualizing trabecular bone structure of the calcaneus are partially SNR-independent: analysis using simulated noise in relation to micro-CT, 1.5T MRI, and biomechanical strength.

Journal of magnetic resonance imaging : JMRI

Bauer JS, Monetti R, Krug R, Matsuura M, Mueller D, Eckstein F, Rummeny EJ, Lochmueller EM, Raeth CW, Link TM

Feasibility and reproducibility of relaxometry, morphometric, and geometrical measurements of the hip joint with magnetic resonance imaging at 3T.

Journal of magnetic resonance imaging : JMRI

Carballido-Gamio J, Link TM, Li X, Han ET, Krug R, Ries MD, Majumdar S

In vivo determination of bone structure in postmenopausal women: a comparison of HR-pQCT and high-field MR imaging.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Kazakia GJ, Hyun B, Burghardt AJ, Krug R, Newitt DC, de Papp AE, Link TM, Majumdar S

In vivo ultra-high-field magnetic resonance imaging of trabecular bone microarchitecture at 7 T.

Journal of magnetic resonance imaging : JMRI

Krug R, Carballido-Gamio J, Banerjee S, Burghardt AJ, Link TM, Majumdar S

Rapid in vivo musculoskeletal MR with parallel imaging at 7T.

Magnetic resonance in medicine

Banerjee S, Krug R, Carballido-Gamio J, Kelley DA, Xu D, Vigneron DB, Majumdar S

In vivo bone and cartilage MRI using fully-balanced steady-state free-precession at 7 tesla.

Magnetic resonance in medicine

Krug R, Carballido-Gamio J, Banerjee S, Stahl R, Carvajal L, Xu D, Vigneron D, Kelley DA, Link TM, Majumdar S

Assessment of trabecular bone structure comparing magnetic resonance imaging at 3 Tesla with high-resolution peripheral quantitative computed tomography ex vivo and in vivo.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

Krug R, Carballido-Gamio J, Burghardt AJ, Kazakia G, Hyun BH, Jobke B, Banerjee S, Huber M, Link TM, Majumdar S

Automatic prospective registration of high-resolution trabecular bone images of the tibia.

Annals of biomedical engineering

Blumenfeld J, Carballido-Gamio J, Krug R, Blezek DJ, Hancu I, Majumdar S

Fast high-spatial-resolution MRI of the ankle with parallel imaging using GRAPPA at 3 T.

AJR. American journal of roentgenology

Bauer JS, Banerjee S, Henning TD, Krug R, Majumdar S, Link TM

Wavelet-based characterization of vertebral trabecular bone structure from magnetic resonance images at 3 T compared with micro-computed tomographic measurements.

Magnetic resonance imaging

Krug R, Carballido-Gamio J, Burghardt AJ, Haase S, Sedat JW, Moss WC, Majumdar S

Fully balanced steady-state 3D-spin-echo (bSSSE) imaging at 3 Tesla.

Magnetic resonance in medicine

Krug R, Han ET, Banerjee S, Majumdar S

Volumetric cartilage measurements of porcine knee at 1.5-T and 3.0-T MR imaging: evaluation of precision and accuracy.

Radiology

Bauer JS, Krause SJ, Ross CJ, Krug R, Carballido-Gamio J, Ozhinsky E, Majumdar S, Link TM

Feasibility of in vivo structural analysis of high-resolution magnetic resonance images of the proximal femur.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

Krug R, Banerjee S, Han ET, Newitt DC, Link TM, Majumdar S

Wavelet Based Characterization of Vertebral Trabecular Bone Structure from MR Images of Specimen at 3 Tesla Compared to MicroCT Measurements.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

Krug R, Carballido-Gamio J, Burghardt A, Haase S, Sedat J, Moss W, Majumdar S

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