Richard Schneider, PhD

Associate Professor
Orthopaedic Surgery
+1 415 502-3788

Rich graduated from Hampshire College in Amherst, MA in 1991. Following an internship at the Smithsonian Institution in Washington, DC, Rich published his first paper, which was on the development and evolution of the skull in wild canids and domestic dogs. He received his Master's Degree in 1994 and his Doctoral Degree in 1998 from Duke University in Durham, NC. Both of his graduate thesis projects focused on skeletal development and evolution in birds and mammals. Rich also studied embryology at the Marine Biological Laboratory in Woods Hole, MA, and at the Cold Spring Harbor Laboratory on Long Island, NY. For his Postdoctoral work at the University of California at San Francisco (UCSF), Rich investigated molecular mechanisms that pattern the craniofacial skeleton. In 2001, Rich joined the faculty of the Department of Orthopaedic Surgery at UCSF and he is currently Director of the Laboratory for Developmental and Evolutionary Skeletal Biology. He was a founder and a Director of the Graduate Program in Developmental & Stem Cell Biology (DSCB) at UCSF from 2009 to 2013, and he also served as a Director of the Embryology Course at the Marine Biological Laboratory in Woods Hole, MA from 2015 to 2019.

Rich's research has been focused on understanding how individual components of the craniofacial complex achieve their proper size, shape, and functional integration during development and evolution. To address this question, Rich has created a surgical transplantation system that involves two distinct species of birds (quail and duck), which differ considerably in their growth rates and anatomy. The experimental approach is straightforward: stem cells that give rise to craniofacial structures are exchanged between quail and duck embryos. This causes faster developing quail cells and relatively slower maturing duck cells to interact with one another continuously within chimeric "quck" and "duail" embryos. Also, chimeras are challenged to integrate species-specific differences in size and shape between the donor and host. By looking for donor-induced changes to the formation of bone, cartilage, muscle, tendon, nerves, and other tissues, Rich has been able to identify molecular and cellular mechanisms that pattern the craniofacial complex. A goal is to devise novel therapies for regenerating tissues affected by birth defects, disease, and trauma. Rich's work has also helped elucidate the role of development in evolution.

For more than 17 years, Rich has been vigorously engaged in issues related to scholarly communication, academic publishing, and open access (OA). He has spent multiple terms serving as Chair of both the UCSF and the UC System-wide Committee on Library and Scholarly Communication (UCOLASC) of the Academic Senate, and he led the effort to create and unanimously pass an OA Policy for UCSF faculty in 2012. In addition, he helped draft a UC System-wide OA Policy in 2013 and a Presidential OA Policy in 2015. Rich also spearheaded the effort by UCSF to become a signatory to the OA2020 initiative, and he galvanized the Academic Senate to endorse a "Declaration of Rights and Principles to Transform Scholarly Communication," which he devised as Chair of UCOLASC in order to make scholarly communication more open, fair, transparent, and sustainable when applied by UC during license negotiations with journal publishers. Most recently, Rich has been serving on the UC team that is negotiating transformative agreements with publishers and he has been deeply involved in outreach to faculty.

Interests: Skeletal development and evolution, musculoskeletal integration, form & function, craniofacial biology, neural crest biology, bone & cartilage

Publications: 

Exceptional Changes in Skeletal Anatomy under Domestication: The Case of Brachycephaly.

Integrative organismal biology (Oxford, England)

Geiger M, Schoenebeck JJ, Schneider RA, Schmidt MJ, Fischer MS, Sánchez-Villagra MR

Morphological diversity of integumentary traits in fowl domestication: Insights from disparity analysis and embryonic development.

Developmental dynamics : an official publication of the American Association of Anatomists

Núñez-León D, Aguirre-Fernández G, Steiner A, Nagashima H, Jensen P, Stoeckli E, Schneider RA, Sánchez-Villagra MR

Negotiating with scholarly journal publishers: A toolkit from the University of California

Negotiating with scholarly journal publishers: A toolkit from the University of California

Anderson I, MacKie-Mason J, Amin K, Antelman K, Grandstaff T, Houghton S, Nusbaum J, Ong N, Schneider R, Setzer D, Steel V, Waibel G, Watters Westbrook D, Willmott M

The Society for Craniofacial Genetics and Developmental Biology 41st Annual Meeting.

American journal of medical genetics. Part A

Taneyhill LA, Moody SA, Cox T, Klein OD, Marcucio R, Schneider RA, Trainor PA

Cellular Control of Time, Size, and Shape in Development and Evolution.

Cells in Evolutionary Biology

Richard A. Schneider

Cells in Evolutionary Biology: Translating Genotypes into Phenotypes – Past, Present, Future (Hall, BK and Moody, S, editors)

Cellular Control of Time, Size, and Shape in Development and Evolution

Schneider, RA

Neural crest and the origin of species-specific pattern.

Genesis (New York, N.Y. : 2000)

Schneider RA

FGF and TGFß signaling link form and function during jaw development and evolution.

Developmental biology

Woronowicz KC, Gline SE, Herfat ST, Fields AJ, Schneider RA

What’s behind OA2020? Accelerating the transition to open access with introspection and repurposing funds.

College & Research Libraries News

Rachael Samberg, Richard A. Schneider, Anneliese Taylor, Michael Wolfe

It's time for the US to get serious about funding open access

Nature Index

Samberg R, Schneider RA, Taylor, A, Wolfe, M

The London School of Economics and Political Science, LSE Impact Blog

A variety of strategies and funding approaches are required to accelerate the transition to open access

Samberg R, Schneider RA, Anderson I, MacKie-Mason J

Engineered Tissue Folding by Mechanical Compaction of the Mesenchyme.

Developmental cell

Hughes AJ, Miyazaki H, Coyle MC, Zhang J, Laurie MT, Chu D, Vavrušová Z, Schneider RA, Klein OD, Gartner ZJ

The Domestic Dog, J Serpell (Editor)

Evolution of working dogs

Lord, K, Schneider, RA, Coppinger, RP

Secondary Chondrogenesis on The Coronoid Process of The Mandible Requires Both FGF And TGFß Signaling.

The FASEB Journal

Katherine C Woronowicz, Danielle Z Jaul, Safa T Herfat, Aaron J Fields, Jeffrey C Lotz, Richard A Schneider

Neural crest-mediated bone resorption is a determinant of species-specific jaw length.

Developmental biology

Ealba EL, Jheon AH, Hall J, Curantz C, Butcher KD, Schneider RA

Regulation of Jaw Length During Development, Disease, and Evolution.

Current topics in developmental biology

Schneider RA

miR-302 Is Required for Timing of Neural Differentiation, Neural Tube Closure, and Embryonic Viability.

Cell reports

Parchem RJ, Moore N, Fish JL, Parchem JG, Braga TT, Shenoy A, Oldham MC, Rubenstein JL, Schneider RA, Blelloch R

Divergence of craniofacial developmental trajectories among avian embryos.

Developmental dynamics : an official publication of the American Association of Anatomists

Smith FJ, Percival CJ, Young NM, Hu D, Schneider RA, Marcucio RS, Hallgrimsson B

Assessing species-specific contributions to craniofacial development using quail-duck chimeras.

Journal of visualized experiments : JoVE

Fish JL, Schneider RA

Embryonic bauplans and the developmental origins of facial diversity and constraint.

Development (Cambridge, England)

Young NM, Hu D, Lainoff AJ, Smith FJ, Diaz R, Tucker AS, Trainor PA, Schneider RA, Hallgrímsson B, Marcucio RS

Multiple developmental mechanisms regulate species-specific jaw size.

Development (Cambridge, England)

Fish JL, Sklar RS, Woronowicz KC, Schneider RA

Neural Crest Cells: Evolution, Development and Disease. P. Trainor (editor)

Neural Crest-Mediated Tissue Interactions During Craniofacial Development: The Origins of Species-Specific Pattern

Fish J, Schneider RA

Evolution of a developmental mechanism: Species-specific regulation of the cell cycle and the timing of events during craniofacial osteogenesis.

Developmental biology

Hall J, Jheon AH, Ealba EL, Eames BF, Butcher KD, Mak SS, Ladher R, Alliston T, Schneider RA

Smad3 binds Scleraxis and Mohawk and regulates tendon matrix organization.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Berthet E, Chen C, Butcher K, Schneider RA, Alliston T, Amirtharajah M

Molecular and cellular changes associated with the evolution of novel jaw muscles in parrots.

Proceedings. Biological sciences

Tokita M, Nakayama T, Schneider RA, Agata K

Structured three-dimensional co-culture of mesenchymal stem cells with chondrocytes promotes chondrogenic differentiation without hypertrophy.

Osteoarthritis and Cartilage

Cooke ME, Allon AA, Cheng T, Kuo AC, Kim HT, Vail TP, Marcucio RS, Schneider RA, Lotz JC, Alliston T

Timing of ossification in duck, quail, and zebra finch: intraspecific variation, heterochronies, and life history evolution.

Zoological science

Mitgutsch C, Wimmer C, Sánchez-Villagra MR, Hahnloser R, Schneider RA

Mesenchymal and mechanical mechanisms of secondary cartilage induction.

Developmental biology

Solem RC, Eames BF, Tokita M, Schneider RA

NBCe1 in mouse and human ameloblasts may be indirectly regulated by fluoride.

Journal of dental research

Zheng L, Zhang Y, He P, Kim J, Schneider R, Bronckers AL, Lyaruu DM, DenBesten PK

Examination of Bone Ossification Markers in Cochlear Development.

The Laryngoscope

Jolie Chang, Kristin Butcher, Omar Akil, Rich Schneider, Lawrence Lustig, Tamara Alliston

Tissue-specific calibration of extracellular matrix material properties by transforming growth factor-ß and Runx2 in bone is required for hearing.

EMBO reports

Chang JL, Brauer DS, Johnson J, Chen CG, Akil O, Balooch G, Humphrey MB, Chin EN, Porter AE, Butcher K, Ritchie RO, Schneider RA, Lalwani A, Derynck R, Marshall GW, Marshall SJ, Lustig L, Alliston T

Ameloblast differentiation in the human developing tooth: effects of extracellular matrices.

Matrix biology : journal of the International Society for Matrix Biology

He P, Zhang Y, Kim SO, Radlanski RJ, Butcher K, Schneider RA, DenBesten PK

Co-culture of Adult Mesenchymal Stem Cells and Nucleus Pulposus Cells in Bilaminar Pellets for Intervertebral Disc Regeneration.

The International Journal of Spine Surgery

Aliza A. Allon, Richard A. Schneider, Jeffrey C. Lotz

Developmental origins of species-specific muscle pattern.

Developmental biology

Tokita M, Schneider RA

The genesis of cartilage size and shape during development and evolution.

Development (Cambridge, England)

Eames BF, Schneider RA

Mesenchyme-dependent BMP signaling directs the timing of mandibular osteogenesis.

Development (Cambridge, England)

Merrill AE, Eames BF, Weston SJ, Heath T, Schneider RA

Other chimeras: quail-duck and mouse-chick.

Methods in cell biology

Lwigale PY, Schneider RA

The TGF-β Family. Derynck and Miyazono (Editors)

Chapter 21: TGF-β family signalling in mesenchymal differentiation

Derynck R,
Piek E,
Schneider RA,
Choy L,
Alliston T

Skeletogenesis in the swell shark Cephaloscyllium ventriosum.

Journal of anatomy

Eames BF, Allen N, Young J, Kaplan A, Helms JA, Schneider RA

How to tweak a beak: molecular techniques for studying the evolution of size and shape in Darwin's finches and other birds.

BioEssays : news and reviews in molecular, cellular and developmental biology

Schneider RA

Amelogenins in human developing and mature dental pulp.

Journal of dental research

Ye L, Le TQ, Zhu L, Butcher K, Schneider RA, Li W, Besten PK

Patterns of infantile hemangiomas: new clues to hemangioma pathogenesis and embryonic facial development.

Pediatrics

Haggstrom AN, Lammer EJ, Schneider RA, Marcucio R, Frieden IJ

Bone Regeneration and Repair: Biology and Clinical Applications. Lieberman and Friedlaender (Editors)

Common molecular mechanisms regulating fetal bone formation and adult fracture repair

Miclau T,
Schneider RA,
Eames BF,
Helms JA

Bone remodeling during prenatal morphogenesis of the human mental foramen.

European journal of oral sciences

Radlanski RJ, Renz H, Lajvardi S, Schneider RA

Cranial skeletal biology.

Nature

Helms JA, Schneider RA

The cellular and molecular origins of beak morphology.

Science (New York, N.Y.)

Schneider RA, Helms JA

Eur J Oral Sci

Prenatal morphogenesis of the human mental foramen.

Radlanski RJ, Renz H, Müller U, Schneider RA, Marcucio RS, Helms JA.

Orthopaedics. Fitzgerald, Kaufer, and Malkani (Editors)

Embryology of Bone

Schneider RA,
Miclau T,
Helms JA

Local retinoid signaling coordinates forebrain and facial morphogenesis by maintaining FGF8 and SHH.

Development (Cambridge, England)

Schneider RA, Hu D, Rubenstein JL, Maden M, Helms JA

Craniofacial Surgery: Science and Surgical Technique. Lin, Ogle, and Jane (Editors)

Morphogenesis of the Face

Cordero D,
Schneider RA,
Helms JA

Genetic and teratogenic approaches to craniofacial development.

Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists

Young DL, Schneider RA, Hu D, Helms JA

Development and regeneration of the musculoskeletal system.

Current Orthopaedic Practice

Richard A. Schneider, Jill A. Helms

Have gene knockouts caused evolutionary reversals in the mammalian first arch?

BioEssays : news and reviews in molecular, cellular and developmental biology

Smith KK, Schneider RA

The Domestic Dog. Serpell J (Editor)

Evolution of working dogs

Coppinger RP,
Schneider RA

Custom Person Type: