Jonathan Graf, MD

Professor
Medicine
+1 628 206-8189

Graf is interested in translational research, moving laboratory discoveries into the clinic to help patients. He directs the UCSF Rheumatoid Arthritis (RA) Observational Cohort, which has enrolled more than 830 patients at UCSF and ZSFG. The cohort collects clinical information and blood samples from participants, making this information available to researchers at UCSF and beyond and jump-starting investigations that seek to improve treatment of patients with RA.

His own research focuses on cardiovascular risk in RA patients. "The inflammatory response is great if you’re bitten by a tiger, but becomes maladaptive if it persists beyond an acute crisis," said Graf. RA patients have chronic inflammation, which damages the body, including the lining of blood vessels – which is linked to increased risk of heart attack and stroke. Even RA patients whose joint swelling is well controlled appear to be at increased risk. He and his colleagues are testing whether offering advanced therapies to patients currently on standard medications leads to improved blood vessel function.

Interests: Rheumatoid arthritis, cardiovascular risk, diagnostic and prognostic biomarkers, immunology, auto-immunity 

Publications: 

Racial and Ethnic Differences in a Biochemical Marker of Rheumatoid Arthritis Disease Activity.

ACR open rheumatology

Baker R, Mantilla B, Graf J, Katz PP, Goglin S, Barton JL, Liew JW, Wysham KD

Race, Ethnicity and Disparities in Rheumatology Educational Materials.

Arthritis care & research

Strait A, Graf J, Margaretten M, Yazdany J, Goglin S

Low cumulative disease activity is associated with higher bone mineral density in a majority Latinx and Asian US rheumatoid arthritis cohort.

Seminars in arthritis and rheumatism

Wysham KD, Shofer J, Lui G, Trupin L, Andrews JS, Black DM, Graf J, Shoback DM, Katz PP

Activated peripheral blood B cells in rheumatoid arthritis and relationship to anti-TNF treatment and response: randomized clinical trial for anti-TNF effects on B cells.

Arthritis & rheumatology (Hoboken, N.J.)

Meednu N, Barnard J, Callahan K, Coca A, Marston B, Thiele R, Tabechian D, Bolster M, Curtis J, Mackay M, Graf J, Keating R, Smith E, Boyle K, Keyes-Elstein L, Welch B, Goldmuntz E, Anolik JH

POS0459 UNSUPERVISED CLUSTERING IDENTIFIES UNIQUE SUBSETS OF PATIENTS IN A RACIALLY AND ETHNICALLY DIVERSE RHEUMATOID ARTHRITIS COHORT.

Annals of the Rheumatic Diseases

G. Lui, E. Noss, N. Singh, J. Andrews, J. Graf, K. Wysham

Reweighting to address nonparticipation and missing data bias in a longitudinal electronic health record study.

Annals of epidemiology

Gianfrancesco MA, McCulloch CE, Trupin L, Graf J, Schmajuk G, Yazdany J

Structural Changes over a Short Period Are Associated with Functional Assessments in Rheumatoid Arthritis.

The Journal of rheumatology

Shimizu T, Cruz A, Tanaka M, Mamoto K, Pedoia V, Burghardt AJ, Heilmeier U, Link TM, Graf J, Imboden JB, Li X

Vasculitis and peripheral neuropathy.

Current opinion in rheumatology

Graf J, Imboden J

Smoking Is Associated with Higher Disease Activity in Rheumatoid Arthritis: A Longitudinal Study Controlling for Time-varying Covariates.

The Journal of rheumatology

Gianfrancesco MA, Trupin L, Shiboski S, van der Laan M, Graf J, Imboden J, Yazdany J, Schmajuk G

Hypomethylation of CYP2E1 and DUSP22 Promoters Associated With Disease Activity and Erosive Disease Among Rheumatoid Arthritis Patients.

Arthritis & rheumatology (Hoboken, N.J.)

Mok A, Rhead B, Holingue C, Shao X, Quach HL, Quach D, Sinclair E, Graf J, Imboden J, Link T, Harrison R, Chernitskiy V, Barcellos LF, Criswell LA

A 56-Year-Old Man With Visual Changes and Arthralgias.

Arthritis care & research

Goglin SE, Manesh R, Graf JD

Central Nervous System Manifestations of Antiphospholipid Syndrome.

Rheumatic diseases clinics of North America

Graf J

Assessment of 3-month changes in bone microstructure under anti-TNFa therapy in patients with rheumatoid arthritis using high-resolution peripheral quantitative computed tomography (HR-pQCT).

Arthritis research & therapy

Shimizu T, Choi HJ, Heilmeier U, Tanaka M, Burghardt AJ, Gong J, Chanchek N, Link TM, Graf J, Imboden JB, Li X

Evaluating radiocarpal cartilage matrix changes 3-months after anti-TNF treatment for rheumatoid arthritis using MR T1? imaging.

Journal of magnetic resonance imaging : JMRI

Ku E, Pedoia V, Tanaka M, Heilmeier U, Imboden J, Graf J, Link T, Li X

Efficiency Gains for Rheumatology Consultation Using a Novel Electronic Referral System in a Safety-Net Health Setting.

Arthritis care & research

Scheibe MM, Imboden JB, Schmajuk G, Margaretten M, Graf JD, Chen AH, Yelin EH, Yazdany J

Depletion of B-cells with rituximab improves endothelial function and reduces inflammation among individuals with rheumatoid arthritis.

Journal of the American Heart Association

Hsue PY, Scherzer R, Grunfeld C, Imboden J, Wu Y, Del Puerto G, Nitta E, Shigenaga J, Schnell Heringer A, Ganz P, Graf J

Methotrexate and a spleen tyrosine kinase inhibitor cooperate to inhibit responses to peripheral blood B cells in rheumatoid arthritis.

Pharmacology research & perspectives

Coffey G, Betz A, Graf J, Stephens G, Hua Lin P, Imboden J, Sinha U

Neutrophilic urticaria with systemic inflammation: a case series.

JAMA dermatology

Belani H, Gensler L, Bajpai U, Meinhardt E, Graf J, Pincus L, Leslie KS

Poor knowledge of methotrexate associated with older age and limited English-language proficiency in a diverse rheumatoid arthritis cohort.

Arthritis research & therapy

Barton JL, Schmajuk G, Trupin L, Graf J, Imboden J, Yelin EH, Schillinger D

Rheumatic manifestations of cocaine use.

Current opinion in rheumatology

Graf J

DEPLETION OF B-CELLS WITH RITUXIMAB IMPROVES ENDOTHELIAL FUNCTION AND REDUCES INFLAMMATION AMONG INDIVIDUALS WITH RHEUMATOID ARTHRITIS.

Journal of the American College of Cardiology

Priscilla Hsue, Carl Grunfeld, John Imboden, Yuaner Wu, Rebecca Scherzer, Saira Mohammed, Gus del Puerto, Amanda Schnell Heringer, Peter Ganz, Jonathan Graf

Purpura, cutaneous necrosis, and antineutrophil cytoplasmic antibodies associated with levamisole-adulterated cocaine.

Arthritis and rheumatism

Graf J, Lynch K, Yeh CL, Tarter L, Richman N, Nguyen T, Kral A, Dominy S, Imboden J

Detection of levamisole exposure in cocaine users by liquid chromatography-tandem mass spectrometry.

Journal of analytical toxicology

Lynch KL, Dominy SS, Graf J, Kral AH

Levels of plasma fibrinogen are elevated in well-controlled rheumatoid arthritis.

Rheumatology (Oxford, England)

Rooney T, Scherzer R, Shigenaga JK, Graf J, Imboden JB, Grunfeld C

Patient-physician discordance in assessments of global disease severity in rheumatoid arthritis.

Arthritis care & research

Barton JL, Imboden J, Graf J, Glidden D, Yelin EH, Schillinger D

Custom Person Type: