Duygu Tosun-Turgut, PhD

Associate Professor
Radiology & Biomedical Imaging
+1 415 221-4810 ext. 23650

Duygu Tosun-Turgut, PhD, is an Associate Professor and Co-Director of the Center for Imaging of Neurodegenerative Diseases (CIND) at the San Francisco Veterans Affairs Medical Center. Dr. Tosun obtained her BSc in Electrical and Electronic Engineering from Bilkent University, Turkey in 1999, and she received her MSE in Electrical and Computer Engineering from The Johns Hopkins University, Maryland in 2001. In 2003, she completed her MA in Mathematics from The Johns Hopkins University, and she earned her PhD in Electrical and Computer Engineering from The Johns Hopkins University in 2005, followed by a postdoctoral fellowship in Neurology from the University of California, Los Angeles in 2008.

Dr. Tosun’s long-term research goal is to develop new algorithmic approaches for processing and analysis of multi-disciplinary/modality data including neuroimages, genetics, proteomics, as well as cognitive functioning measures in a unified framework by using recent advances in image processing, medical physics, and computation medicine. The primary aim is to identify multi-disciplinary/modality biomarkers for detecting the changes associated with disease specific neuropathology, improving understanding of pathophysiological progression and potentially providing a means of monitoring the efficacy and regional specificity of drug therapy for neurodegenerative diseases. This will have a broad use in early diagnosis, facilitating initiation of prevention strategies in those at risk, and boost the power of drug therapy trials by selecting those at greatest risk of neurodegenerative diseases.

Dr. Tosun is a reviewer for 17 scientific journals. She has 29 published articles and she has written 30 peer-reviewed articles, 50 abstracts, and 5 significant publications.

Interests: neuroimaging, frailty, aging, neurodegenerative diseases, dementia, multimodality, MRI, PET, computational medicine, imaging biomarkers, neuropathology

Publications: 

Magnetic resonance imaging of the lumbar spine-recommendations for acquisition and image evaluation from the BACPAC Spine Imaging Working Group.

Pain medicine (Malden, Mass.)

Sollmann N, Fields AJ, O'Neill C, Nardo L, Majumdar S, Chin CT, Tosun D, Han M, Vu AT, Ozhinsky E, Shah LM, Harris RE, Lobo R, Anderst W, Herzog R, Psioda MA, Standaert CJ, Price RT, Lotz JC, Link TM, Krug R

Revealing Individual Neuroanatomical Heterogeneity in Alzheimer Disease Using Neuroanatomical Normative Modeling.

Neurology

Verdi S, Kia SM, Yong KXX, Tosun D, Schott JM, Marquand AF, Cole JH

AI-based dimensional neuroimaging system for characterizing heterogeneity in brain structure and function in major depressive disorder: COORDINATE-MDD consortium design and rationale.

BMC psychiatry

Fu CHY, Erus G, Fan Y, Antoniades M, Arnone D, Arnott SR, Chen T, Choi KS, Fatt CC, Frey BN, Frokjaer VG, Ganz M, Garcia J, Godlewska BR, Hassel S, Ho K, McIntosh AM, Qin K, Rotzinger S, Sacchet MD, Savitz J, Shou H, Singh A, Stolicyn A, Strigo I, Strother SC, Tosun D, Victor TA, Wei D, Wise T, Woodham RD, Zahn R, Anderson IM, Deakin JFW, Dunlop BW, Elliott R, Gong Q, Gotlib IH, Harmer CJ, Kennedy SH, Knudsen GM, Mayberg HS, Paulus MP, Qiu J, Trivedi MH, Whalley HC, Yan CG, Young AH, Davatzikos C

Increasing participant diversity in AD research: Plans for digital screening, blood testing, and a community-engaged approach in the Alzheimer's Disease Neuroimaging Initiative 4.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Weiner MW, Veitch DP, Miller MJ, Aisen PS, Albala B, Beckett LA, Green RC, Harvey D, Jack CR, Jagust W, Landau SM, Morris JC, Nosheny R, Okonkwo OC, Perrin RJ, Petersen RC, Rivera-Mindt M, Saykin AJ, Shaw LM, Toga AW, Tosun D, Trojanowski JQ, Alzheimer's Disease Neuroimaging Initiative

A 1-year randomized controlled trial of a nutritional blend to improve nutritional biomarkers and prevent cognitive decline among community-dwelling older adults: The Nolan Study.

Alzheimer's & dementia (New York, N. Y.)

Giudici KV, Guyonnet S, Cantet C, de Souto Barreto P, Weiner MW, Tosun D, Boschat C, Hudry J, Andrieu S, Vellas B, Schmitt JAJ, Nolan/DSA group

Cognitive outcomes are differentially associated with depression severity trajectories during psychotherapy treatment for late life major depressive disorder.

International journal of geriatric psychiatry

Kassel MT, Rhodes E, Insel PS, Woodworth K, Garrison-Diehn C, Satre DD, Nelson JC, Tosun D, Mackin RS

ß-amyloid PET harmonisation across longitudinal studies: Application to AIBL, ADNI and OASIS3.

NeuroImage

Bourgeat P, Doré V, Burnham SC, Benzinger T, Tosun D, Li S, Goyal M, LaMontagne P, Jin L, Rowe CC, Weiner MW, Morris JC, Masters CL, Fripp J, Villemagne VL, Alzheimer's Disease Neuroimaging Initiative, OASIS3, and the AIBL research group

Traumatic brain injury and post-traumatic stress disorder are not associated with Alzheimer's disease pathology measured with biomarkers.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Weiner MW, Harvey D, Landau SM, Veitch DP, Neylan TC, Grafman JH, Aisen PS, Petersen RC, Jack CR, Tosun D, Shaw LM, Trojanowski JQ, Saykin AJ, Hayes J, De Carli C, Alzheimer's Disease Neuroimaging Initiative and the Department of Defense Alzheimer's Disease Neuroi

Characterizing Heterogeneity in Neuroimaging, Cognition, Clinical Symptoms, and Genetics Among Patients With Late-Life Depression.

JAMA psychiatry

Wen J, Fu CHY, Tosun D, Veturi Y, Yang Z, Abdulkadir A, Mamourian E, Srinivasan D, Skampardoni I, Singh A, Nawani H, Bao J, Erus G, Shou H, Habes M, Doshi J, Varol E, Mackin RS, Sotiras A, Fan Y, Saykin AJ, Sheline YI, Shen L, Ritchie MD, Wolk DA, Albert M, Resnick SM, Davatzikos C, iSTAGING consortium, ADNI, BIOCARD, and BLSA

Network-wise concordance of multimodal neuroimaging features across the Alzheimer's disease continuum.

Alzheimer's & dementia (Amsterdam, Netherlands)

Stocks J, Popuri K, Heywood A, Tosun D, Alpert K, Beg MF, Rosen H, Wang L, Alzheimer's Disease Neuroimaging Initiative

Regional uptakes from early-frame amyloid PET and 18F-FDG PET scans are comparable independent of disease state.

European journal of hybrid imaging

Myoraku A, Klein G, Landau S, Tosun D, Alzheimer’s Disease Neuroimaging Initiative

Age-dependent brain morphometry in Major Depressive disorder.

NeuroImage. Clinical

Myoraku A, Lang A, Taylor CT, Scott Mackin R, Meyerhoff DJ, Mueller S, Strigo IA, Tosun D

Thalamic Dorsomedial Nucleus Free Water Correlates with Cognitive Decline in Parkinson's Disease.

Movement disorders : official journal of the Movement Disorder Society

Guttuso T, Sirica D, Tosun D, Zivadinov R, Pasternak O, Weintraub D, Baglio F, Bergsland N

Deep learning for Alzheimer's disease: Mapping large-scale histological tau protein for neuroimaging biomarker validation.

NeuroImage

Ushizima D, Chen Y, Alegro M, Ovando D, Eser R, Lee W, Poon K, Shankar A, Kantamneni N, Satrawada S, Junior EA, Heinsen H, Tosun D, Grinberg LT

Using imputation to provide harmonized longitudinal measures of cognition across AIBL and ADNI.

Scientific reports

Shishegar R, Cox T, Rolls D, Bourgeat P, Doré V, Lamb F, Robertson J, Laws SM, Porter T, Fripp J, Tosun D, Maruff P, Savage G, Rowe CC, Masters CL, Weiner MW, Villemagne VL, Burnham SC

White matter changes in drug-naïve Parkinson's disease patients with impulse control & probable REM sleep behavior disorders.

Journal of the Neurological Sciences

Dolatshahi M, Ashraf-Ganjouei A, Wu IW, Zhang Y, Aarabi MH, Tosun D, Parkinson's Progression Marker Initiative

Contribution of Alzheimer's biomarkers and risk factors to cognitive impairment and decline across the Alzheimer's disease continuum.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Tosun D, Demir Z, Veitch DP, Weintraub D, Aisen P, Jack CR, Jagust WJ, Petersen RC, Saykin AJ, Shaw LM, Trojanowski JQ, Weiner MW, Alzheimer's Disease Neuroimaging Initiative

Using the Alzheimer's Disease Neuroimaging Initiative to improve early detection, diagnosis, and treatment of Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Veitch DP, Weiner MW, Aisen PS, Beckett LA, DeCarli C, Green RC, Harvey D, Jack CR, Jagust W, Landau SM, Morris JC, Okonkwo O, Perrin RJ, Petersen RC, Rivera-Mindt M, Saykin AJ, Shaw LM, Toga AW, Tosun D, Trojanowski JQ, Alzheimer's Disease Neuroimaging Initiative

Network-constrained technique to characterize pathology progression rate in Alzheimer's disease.

Brain communications

Powell F, Tosun D, Raj A, Alzheimer’s Disease Neuroimaging Initiative

ADAMANT: a placebo-controlled randomized phase 2 study of AADvac1, an active immunotherapy against pathological tau in Alzheimer's disease.

Nature aging

Novak P, Kovacech B, Katina S, Schmidt R, Scheltens P, Kontsekova E, Ropele S, Fialova L, Kramberger M, Paulenka-Ivanovova N, Smisek M, Hanes J, Stevens E, Kovac A, Sutovsky S, Parrak V, Koson P, Prcina M, Galba J, Cente M, Hromadka T, Filipcik P, Piestansky J, Samcova M, Prenn-Gologranc C, Sivak R, Froelich L, Fresser M, Rakusa M, Harrison J, Hort J, Otto M, Tosun D, Ondrus M, Winblad B, Novak M, Zilka N

The search for a convenient procedure to detect one of the earliest signs of Alzheimer's disease: A systematic review of the prediction of brain amyloid status.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Ashford MT, Veitch DP, Neuhaus J, Nosheny RL, Tosun D, Weiner MW

Lower cerebral perfusion is associated with tau-PET in the entorhinal cortex across the Alzheimer's continuum.

Neurobiology of aging

Rubinski A, Tosun D, Franzmeier N, Neitzel J, Frontzkowski L, Weiner M, Ewers M

Detection of β-amyloid positivity in Alzheimer's Disease Neuroimaging Initiative participants with demographics, cognition, MRI and plasma biomarkers.

Brain communications

Tosun D, Veitch D, Aisen P, Jack CR, Jagust WJ, Petersen RC, Saykin AJ, Bollinger J, Ovod V, Mawuenyega KG, Bateman RJ, Shaw LM, Trojanowski JQ, Blennow K, Zetterberg H, Weiner MW

The Impact of Amyloid Burden and APOE on Rates of Cognitive Impairment in Late Life Depression.

Journal of Alzheimer's disease : JAD

Rhodes E, Insel PS, Butters MA, Morin R, Bickford D, Tosun D, Gessert D, Rosen HJ, Aisen P, Raman R, Landau S, Saykin A, Toga A, Jack CR, Weiner MW, Nelson C, Mackin S, Alzheimer’s Disease Neuroimaging Initiative, ADNI Depression Project

Improvements in Functional Disability After Psychotherapy for Depression Are Associated With Reduced Suicide Ideation Among Older Adults.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Lutz J, Mackin RS, Otero MC, Morin R, Bickford D, Tosun D, Satre DD, Gould CE, Nelson JC, Beaudreau SA

Late-Life Depression Is Associated With Reduced Cortical Amyloid Burden: Findings From the Alzheimer's Disease Neuroimaging Initiative Depression Project.

Biological psychiatry

Mackin RS, Insel PS, Landau S, Bickford D, Morin R, Rhodes E, Tosun D, Rosen HJ, Butters M, Aisen P, Raman R, Saykin A, Toga A, Jack C, Koeppe R, Weiner MW, Nelson C, Alzheimer’s Disease Neuroimaging Initiative and the ADNI Depression Project

Clinical and Dopamine Transporter Imaging Characteristics of Leucine Rich Repeat Kinase 2 (LRRK2) and Glucosylceramidase Beta (GBA) Parkinson's Disease Participants in the Parkinson's Progression Markers Initiative: A Cross-Sectional Study.

Movement disorders : official journal of the Movement Disorder Society

Simuni T, Brumm MC, Uribe L, Caspell-Garcia C, Coffey CS, Siderowf A, Alcalay RN, Trojanowski JQ, Shaw LM, Seibyl J, Singleton A, Toga AW, Galasko D, Foroud T, Nudelman K, Tosun-Turgut D, Poston K, Weintraub D, Mollenhauer B, Tanner CM, Kieburtz K, Chahine LM, Reimer A, Hutten S, Bressman S, Marek K, Parkinson's Progression Markers Initiative Investigators

Clinical and dopamine transporter imaging characteristics of non-manifest LRRK2 and GBA mutation carriers in the Parkinson's Progression Markers Initiative (PPMI): a cross-sectional study.

The Lancet. Neurology

Simuni T, Uribe L, Cho HR, Caspell-Garcia C, Coffey CS, Siderowf A, Trojanowski JQ, Shaw LM, Seibyl J, Singleton A, Toga AW, Galasko D, Foroud T, Tosun D, Poston K, Weintraub D, Mollenhauer B, Tanner CM, Kieburtz K, Chahine LM, Reimer A, Hutten SJ, Bressman S, Marek K, PPMI Investigators

Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases.

Brain : a journal of neurology

Betts MJ, Kirilina E, Otaduy MCG, Ivanov D, Acosta-Cabronero J, Callaghan MF, Lambert C, Cardenas-Blanco A, Pine K, Passamonti L, Loane C, Keuken MC, Trujillo P, Lüsebrink F, Mattern H, Liu KY, Priovoulos N, Fliessbach K, Dahl MJ, Maaß A, Madelung CF, Meder D, Ehrenberg AJ, Speck O, Weiskopf N, Dolan R, Inglis B, Tosun D, Morawski M, Zucca FA, Siebner HR, Mather M, Uludag K, Heinsen H, Poser BA, Howard R, Zecca L, Rowe JB, Grinberg LT, Jacobs HIL, Düzel E, Hämmerer D

Associations among amyloid status, age, and longitudinal regional brain atrophy in cognitively unimpaired older adults.

Neurobiology of aging

Nosheny RL, Insel PS, Mattsson N, Tosun D, Buckley S, Truran D, Schuff N, Aisen PS, Weiner MW, Alzheimer's Disease Neuroimaging Initiative

Polygenic hazard score, amyloid deposition and Alzheimer's neurodegeneration.

Brain : a journal of neurology

Tan CH, Bonham LW, Fan CC, Mormino EC, Sugrue LP, Broce IJ, Hess CP, Yokoyama JS, Rabinovici GD, Miller BL, Yaffe K, Schellenberg GD, Kauppi K, Holland D, McEvoy LK, Kukull WA, Tosun D, Weiner MW, Sperling RA, Bennett DA, Hyman BT, Andreassen OA, Dale AM, Desikan RS, Alzheimer’s Disease Neuroimaging Initiative

The Parkinson's progression markers initiative (PPMI) - establishing a PD biomarker cohort.

Annals of clinical and translational neurology

Marek K, Chowdhury S, Siderowf A, Lasch S, Coffey CS, Caspell-Garcia C, Simuni T, Jennings D, Tanner CM, Trojanowski JQ, Shaw LM, Seibyl J, Schuff N, Singleton A, Kieburtz K, Toga AW, Mollenhauer B, Galasko D, Chahine LM, Weintraub D, Foroud T, Tosun-Turgut D, Poston K, Arnedo V, Frasier M, Sherer T, Parkinson's Progression Markers Initiative

Chronic depressive symptomatology and CSF amyloid beta and tau levels in mild cognitive impairment.

International journal of geriatric psychiatry

Gonzales MM, Insel PS, Nelson C, Tosun D, Schöll M, Mattsson N, Sacuiu S, Bickford D, Weiner MW, Mackin RS, Alzheimer's Disease Neuroimaging Initiative

Telomere attrition is associated with declines in medial temporal lobe volume and white matter microstructure in functionally independent older adults.

Neurobiology of aging

Staffaroni AM, Tosun D, Lin J, Elahi FM, Casaletto KB, Wynn MJ, Patel N, Neuhaus J, Walters SM, Epel ES, Blackburn EH, Kramer JH

Longitudinal Change of Clinical and Biological Measures in Early Parkinson's Disease: Parkinson's Progression Markers Initiative Cohort.

Movement disorders : official journal of the Movement Disorder Society

Simuni T, Siderowf A, Lasch S, Coffey CS, Caspell-Garcia C, Jennings D, Tanner CM, Trojanowski JQ, Shaw LM, Seibyl J, Schuff N, Singleton A, Kieburtz K, Toga AW, Mollenhauer B, Galasko D, Chahine LM, Weintraub D, Foroud T, Tosun D, Poston K, Arnedo V, Frasier M, Sherer T, Chowdhury S, Marek K, Parkinson's Progression Marker Initiative*

Preserved Structural Network Organization Mediates Pathology Spread in Alzheimer's Disease Spectrum Despite Loss of White Matter Tract Integrity.

Journal of Alzheimer's disease : JAD

Powell F, Tosun D, Sadeghi R, Weiner M, Raj A, Alzheimer’s Disease Neuroimaging Initiative

Longitudinal white matter change in frontotemporal dementia subtypes and sporadic late onset Alzheimer's disease.

NeuroImage. Clinical

Elahi FM, Marx G, Cobigo Y, Staffaroni AM, Kornak J, Tosun D, Boxer AL, Kramer JH, Miller BL, Rosen HJ

Effects of traumatic brain injury and posttraumatic stress disorder on development of Alzheimer's disease in Vietnam Veterans using the Alzheimer's Disease Neuroimaging Initiative: Preliminary Report.

Alzheimer's & dementia (New York, N. Y.)

Weiner MW, Harvey D, Hayes J, Landau SM, Aisen PS, Petersen RC, Tosun D, Veitch DP, Jack CR, Decarli C, Saykin AJ, Grafman J, Neylan TC, Department of Defense Alzheimer's Disease Neuroimaging Initiative

Multiple modality biomarker prediction of cognitive impairment in prospectively followed de novo Parkinson disease.

PloS one

Caspell-Garcia C, Simuni T, Tosun-Turgut D, Wu IW, Zhang Y, Nalls M, Singleton A, Shaw LA, Kang JH, Trojanowski JQ, Siderowf A, Coffey C, Lasch S, Aarsland D, Burn D, Chahine LM, Espay AJ, Foster ED, Hawkins KA, Litvan I, Richard I, Weintraub D, Parkinson’s Progression Markers Initiative (PPMI)

Association between tau deposition and antecedent amyloid-ß accumulation rates in normal and early symptomatic individuals.

Brain : a journal of neurology

Tosun D, Landau S, Aisen PS, Petersen RC, Mintun M, Jagust W, Weiner MW, Alzheimer’s Disease Neuroimaging Initiative

?Cortical Atrophy is Associated with Accelerated Cognitive Decline in Mild Cognitive Impairment with Subsyndromal Depression.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Gonzales MM, Insel PS, Nelson C, Tosun D, Mattsson N, Mueller SG, Sacuiu S, Bickford D, Weiner MW, Mackin RS, Alzheimer's Disease Neuroimaging Initiative

Independent value added by diffusion MRI for prediction of cognitive function in older adults.

NeuroImage. Clinical

Scott JA, Tosun D, Braskie MN, Maillard P, Thompson PM, Weiner M, DeCarli C, Carmichael OT, ADNI

Progression of Regional Microstructural Degeneration in Parkinson's Disease: A Multicenter Diffusion Tensor Imaging Study.

PloS one

Zhang Y, Wu IW, Tosun D, Foster E, Schuff N, Parkinson’s Progression Markers Initiative

Diagnostic utility of ASL-MRI and FDG-PET in the behavioral variant of FTD and AD.

Annals of clinical and translational neurology

Tosun D, Schuff N, Rabinovici GD, Ayakta N, Miller BL, Jagust W, Kramer J, Weiner MM, Rosen HJ

Cerebral amyloid is associated with greater white-matter hyperintensity accrual in cognitively normal older adults.

Neurobiology of aging

Scott JA, Braskie MN, Tosun D, Maillard P, Thompson PM, Weiner M, DeCarli C, Carmichael OT, ADNI

Amyloid status imputed from a multimodal classifier including structural MRI distinguishes progressors from nonprogressors in a mild Alzheimer's disease clinical trial cohort.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Tosun D, Chen YF, Yu P, Sundell KL, Suhy J, Siemers E, Schwarz AJ, Weiner MW, Alzheimer's Disease Neuroimaging Initiative

Accelerating rates of cognitive decline and imaging markers associated with ß-amyloid pathology.

Neurology

Insel PS, Mattsson N, Mackin RS, Schöll M, Nosheny RL, Tosun D, Donohue MC, Aisen PS, Jagust WJ, Weiner MW, Alzheimer's Disease Neuroimaging Initiative

Preliminary Evidence of Increased Hippocampal Myelin Content in Veterans with Posttraumatic Stress Disorder.

Frontiers in behavioral neuroscience

Chao LL, Tosun D, Woodward SH, Kaufer D, Neylan TC

Cerebral Amyloid and Hypertension are Independently Associated with White Matter Lesions in Elderly.

Frontiers in aging neuroscience

Scott JA, Braskie MN, Tosun D, Thompson PM, Weiner M, DeCarli C, Carmichael OT, Alzheimer’s Disease Neuroimaging Initiative

Chronic Depressive Symptomatology in Mild Cognitive Impairment Is Associated with Frontal Atrophy Rate which Hastens Conversion to Alzheimer Dementia.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Sacuiu S, Insel PS, Mueller S, Tosun D, Mattsson N, Jack CR, DeCarli C, Petersen R, Aisen PS, Weiner MW, Mackin RS, Alzheimer's Disease Neuroimaging Initiative

Biomarkers and cognitive endpoints to optimize trials in Alzheimer's disease.

Annals of clinical and translational neurology

Insel PS, Mattsson N, Mackin RS, Kornak J, Nosheny R, Tosun-Turgut D, Donohue MC, Aisen PS, Weiner MW, Alzheimer's Disease Neuroimaging Initiative

Brain amyloid-ß burden is associated with disruption of intrinsic functional connectivity within the medial temporal lobe in cognitively normal elderly.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Song Z, Insel PS, Buckley S, Yohannes S, Mezher A, Simonson A, Wilkins S, Tosun D, Mueller S, Kramer JH, Miller BL, Weiner MW

Network Diffusion Model of Progression Predicts Longitudinal Patterns of Atrophy and Metabolism in Alzheimer's Disease.

Cell reports

Raj A, LoCastro E, Kuceyeski A, Tosun D, Relkin N, Weiner M, Alzheimer’s Disease Neuroimaging Initiative (ADNI)

Emerging ß-amyloid pathology and accelerated cortical atrophy.

JAMA neurology

Mattsson N, Insel PS, Nosheny R, Tosun D, Trojanowski JQ, Shaw LM, Jack CR, Donohue MC, Weiner MW, Alzheimer’s Disease Neuroimaging Initiative

Parallel ICA of FDG-PET and PiB-PET in three conditions with underlying Alzheimer's pathology.

NeuroImage. Clinical

Laforce R, Tosun D, Ghosh P, Lehmann M, Madison CM, Weiner MW, Miller BL, Jagust WJ, Rabinovici GD

Association of brain amyloid-ß with cerebral perfusion and structure in Alzheimer's disease and mild cognitive impairment.

Brain : a journal of neurology

Mattsson N, Tosun D, Insel PS, Simonson A, Jack CR, Beckett LA, Donohue M, Jagust W, Schuff N, Weiner MW, Alzheimer's Disease Neuroimaging Initiative

Multimodal MRI-based Imputation of the Aß+ in Early Mild Cognitive Impairment.

Annals of clinical and translational neurology

Tosun D, Joshi S, Weiner MW, the Alzheimer’s Disease Neuroimaging Initiative

Effects of baseline CSF a-synuclein on regional brain atrophy rates in healthy elders, mild cognitive impairment and Alzheimer's disease.

PloS one

Mattsson N, Insel P, Tosun D, Zhang J, Jack CR, Galasko D, Weiner M, Alzheimer’s Disease Neuroimaging Initiative

Effects of cerebrospinal fluid proteins on brain atrophy rates in cognitively healthy older adults.

Neurobiology of aging

Mattsson N, Insel P, Nosheny R, Trojanowski JQ, Shaw LM, Jack CR, Tosun D, Weiner M, Alzheimer's Disease Neuroimaging Initiative

Neuroimaging predictors of brain amyloidosis in mild cognitive impairment.

Annals of neurology

Tosun D, Joshi S, Weiner MW, Alzheimer's Disease Neuroimaging Initiative

CSF protein biomarkers predicting longitudinal reduction of CSF ß-amyloid42 in cognitively healthy elders.

Translational psychiatry

Mattsson N, Insel P, Nosheny R, Zetterberg H, Trojanowski JQ, Shaw LM, Tosun D, Weiner M, Alzheimer's Disease Neuroimaging Initiative

Locally linear embedding (LLE) for MRI based Alzheimer's disease classification.

NeuroImage

Liu X, Tosun D, Weiner MW, Schuff N, Alzheimer's Disease Neuroimaging Initiative

Voxel-wise co-analysis of macro- and microstructural brain alteration in mild cognitive impairment and Alzheimer's disease using anatomical and diffusion MRI.

Journal of neuroimaging : official journal of the American Society of Neuroimaging

Cardenas VA, Tosun D, Chao LL, Fletcher PT, Joshi S, Weiner MW, Schuff N

Voxelwise multivariate analysis of multimodality magnetic resonance imaging.

Human brain mapping

Naylor MG, Cardenas VA, Tosun D, Schuff N, Weiner M, Schwartzman A

Patterns of reduced cortical thickness in late-life depression and relationship to psychotherapeutic response.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Mackin RS, Tosun D, Mueller SG, Lee JY, Insel P, Schuff N, Truran-Sacrey D, Arean P, Nelson JC, Weiner MW

The effect of subsyndromal symptoms of depression and white matter lesions on disability for individuals with mild cognitive impairment.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Mackin RS, Insel P, Tosun D, Mueller SG, Schuff N, Truran-Sacrey D, Raptentsetsang ST, Lee JY, Jack CR, Aisen PS, Petersen RC, Weiner MW, Alzheimer's Disease Neuroimaging Initiative

Patterns of Reduced Cortical Thickness in Late-Life Depression and Relationship to Psychotherapeutic Response.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Mackin RS, Tosun D, Mueller SG, Lee JY, Insel P, Schuff N, Truran-Sacrey D, Arean P, Nelson JC, Weiner MW

Increased Cortical Thickness in Male-to-Female Transsexualism.

Journal of behavioral and brain science

Luders E, Sánchez FJ, Tosun D, Shattuck DW, Gaser C, Vilain E, Toga AW

Impact of apolipoprotein E4-cerebrospinal fluid ß-amyloid interaction on hippocampal volume loss over 1 year in mild cognitive impairment.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Chiang GC, Insel PS, Tosun D, Schuff N, Truran-Sacrey D, Raptentsetsang ST, Thompson PM, Reiman EM, Jack CR, Fox NC, Jagust WJ, Harvey DJ, Beckett LA, Gamst A, Aisen PS, Petersen RC, Weiner MW, Alzheimer's Disease Neuroimaging Initiative

Impact of methodologic choice for automatic detection of different aspects of brain atrophy by using temporal lobe epilepsy as a model.

AJNR. American journal of neuroradiology

Scanlon C, Mueller SG, Tosun D, Cheong I, Garcia P, Barakos J, Weiner MW, Laxer KD

Joint assessment of structural, perfusion, and diffusion MRI in Alzheimer's disease and frontotemporal dementia.

International journal of Alzheimer's disease

Zhang Y, Schuff N, Ching C, Tosun D, Zhan W, Nezamzadeh M, Rosen HJ, Kramer JH, Gorno-Tempini ML, Miller BL, Weiner MW

Intelligence and cortical thickness in children with complex partial seizures.

NeuroImage

Tosun D, Caplan R, Siddarth P, Seidenberg M, Gurbani S, Toga AW, Hermann B

Identifying cognitively healthy elderly individuals with subsequent memory decline by using automated MR temporoparietal volumes.

Radiology

Chiang GC, Insel PS, Tosun D, Schuff N, Truran-Sacrey D, Raptentsetsang S, Jack CR, Weiner MW, Alzheimer's Disease Neuroimaging Initiative

Spatial patterns of brain amyloid-beta burden and atrophy rate associations in mild cognitive impairment.

Brain : a journal of neurology

Tosun D, Schuff N, Mathis CA, Jagust W, Weiner MW, Alzheimer's Disease NeuroImaging Initiative

Cortical thickness, surface area, and volume of the brain reward system in alcohol dependence: relationships to relapse and extended abstinence.

Alcoholism, clinical and experimental research

Durazzo TC, Tosun D, Buckley S, Gazdzinski S, Mon A, Fryer SL, Meyerhoff DJ

Deformation-based morphometry of prospective neurodevelopmental changes in new onset paediatric epilepsy.

Brain : a journal of neurology

Tosun D, Dabbs K, Caplan R, Siddarth P, Toga A, Seidenberg M, Hermann B

Relationship between CSF biomarkers of Alzheimer's disease and rates of regional cortical thinning in ADNI data.

Journal of Alzheimer's disease : JAD

Tosun D, Schuff N, Shaw LM, Trojanowski JQ, Weiner MW, Alzheimer's Disease NeuroImaging Initiative

Hippocampal atrophy rates and CSF biomarkers in elderly APOE2 normal subjects.

Neurology

Chiang GC, Insel PS, Tosun D, Schuff N, Truran-Sacrey D, Raptentsetsang ST, Jack CR, Aisen PS, Petersen RC, Weiner MW, Alzheimer's Disease Neuroimaging Initiative

Nonlinear time course of brain volume loss in cognitively normal and impaired elders.

Neurobiology of aging

Schuff N, Tosun D, Insel PS, Chiang GC, Truran D, Aisen PS, Jack CR, Weiner MW, Alzheimer's Disease Neuroimaging Initiative

Relations between brain tissue loss, CSF biomarkers, and the ApoE genetic profile: a longitudinal MRI study.

Neurobiology of aging

Tosun D, Schuff N, Truran-Sacrey D, Shaw LM, Trojanowski JQ, Aisen P, Peterson R, Weiner MW, Alzheimer's Disease Neuroimaging Initiative

Update on the magnetic resonance imaging core of the Alzheimer's disease neuroimaging initiative.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Jack CR, Bernstein MA, Borowski BJ, Gunter JL, Fox NC, Thompson PM, Schuff N, Krueger G, Killiany RJ, Decarli CS, Dale AM, Carmichael OW, Tosun D, Weiner MW, Alzheimer's Disease Neuroimaging Initiative

An integrated multimodality MR brain imaging study: gray matter tissue loss mediates the association between cerebral hypoperfusion and Alzheimer's disease.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

Tosun D, Schuff N, Weiner M

3-D analysis of cortical morphometry in differential diagnosis of Parkinson's plus syndromes: mapping frontal lobe cortical atrophy in progressive supranuclear palsy patients.

Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention

Tosun D, Duchesne S, Rolland Y, Toga AW, Vérin M, Barillot C

Cortical reconstruction using implicit surface evolution: accuracy and precision analysis.

NeuroImage

Tosun D, Rettmann ME, Naiman DQ, Resnick SM, Kraut MA, Prince JL

Program for Assisted Labeling of Sulcal Regions (PALS): description and reliability.

NeuroImage

Rettmann ME, Tosun D, Tao X, Resnick SM, Prince JL

Cortical surface alignment using geometry driven multispectral optical flow.

Information processing in medical imaging : proceedings of the ... conference

Tosun D, Prince JL

CRUISE: cortical reconstruction using implicit surface evolution.

NeuroImage

Han X, Pham DL, Tosun D, Rettmann ME, Xu C, Prince JL

Mapping techniques for aligning sulci across multiple brains.

Medical image analysis

Tosun D, Rettmann ME, Prince JL

Cortical surface segmentation and mapping.

NeuroImage

Tosun D, Rettmann ME, Han X, Tao X, Xu C, Resnick SM, Pham DL, Prince JL