Alfred Kuo, MD, PhD

Professor
Orthopaedic Surgery
+1 415 221-4810 ext. 3259

Alfred Kuo graduated from the University of California, Berkeley with a degree in biochemistry, and then went on to receive a PhD in biochemistry and his medical degree at UCSF as part of the Medical Scientist Training Program. He was a resident in orthopaedic surgery and a research fellow at the University of California, Davis before completing a fellowship in lower extremity reconstruction at the Scripps Clinic in San Diego.

Kuo has received numerous awards and has published papers in Osteoarthritis and Cartilage, the Journal of Arthroplasty and the Journal of Cell Biology. Here at UCSF, he works closely with Hubert Kim, MD, PhD at San Francisco Veterans Medical Center, attends surgery and clinic at San Francisco General Hospital and continues his basic research.

Interests: Articular cartilage, endochondral ossification, cell-based therapies

Publications: 

A Tool to Estimate Risk of 30-day Mortality and Complications After Hip Fracture Surgery: Accurate Enough for Some but Not All Purposes? A Study From the ACS-NSQIP Database.

Clinical orthopaedics and related research

Harris AHS, Trickey AW, Eddington HS, Seib CD, Kamal RN, Kuo AC, Ding Q, Giori NJ

What Factors Lead to Racial Disparities in Outcomes After Total Knee Arthroplasty?

Journal of racial and ethnic health disparities

Hu DA, Hu JB, Lee A, Rubenstein WJ, Hwang KM, Ibrahim SA, Kuo AC

Hepatitis C infection and complication rates after total shoulder arthroplasty in United States veterans.

JSES international

Su F, Cogan CJ, Bendich I, Zhang N, Whooley MA, Kuo AC

Antibiotic-Laden Bone Cement Use and Revision Risk After Primary Total Knee Arthroplasty in U.S. Veterans.

The Journal of bone and joint surgery. American volume

Bendich I, Zhang N, Barry JJ, Ward DT, Whooley MA, Kuo AC

Social Determinants of Health and Patient-Reported Outcomes Following Total Hip and Knee Arthroplasty in Veterans.

The Journal of arthroplasty

Rubenstein WJ, Harris AHS, Hwang KM, Giori NJ, Kuo AC

Does Implant Choice Affect the Episode Cost of Pertrochanteric Hip Fracture for US Veterans?

Journal of orthopaedic trauma

Patterson JT, Takemoto SK, Shearer DW, Kuo AC

Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis.

Bone research

Mazur CM, Woo JJ, Yee CS, Fields AJ, Acevedo C, Bailey KN, Kaya S, Fowler TW, Lotz JC, Dang A, Kuo AC, Vail TP, Alliston T

Preoperative Treatment of Hepatitis C Is Associated With Lower Prosthetic Joint Infection Rates in US Veterans.

The Journal of arthroplasty

Bendich I, Takemoto S, Patterson JT, Monto A, Barber TC, Kuo AC

Can Machine Learning Methods Produce Accurate and Easy-to-use Prediction Models of 30-day Complications and Mortality After Knee or Hip Arthroplasty?

Clinical orthopaedics and related research

Harris AHS, Kuo AC, Weng Y, Trickey AW, Bowe T, Giori NJ

Freedom From Opioids After Total Knee Arthroplasty.

The Journal of arthroplasty

Kuo AC, Raghunathan K, Lartigue AM, Bryan WE, Pepin MJ, Takemoto S, Wallace AW

Repurposing Human Osteoarthritic Cartilage as a Bone Graft Substitute in an Athymic Rat Posterolateral Spinal Fusion Model.

International journal of spine surgery

Dang ABC, Hong H, Lee K, Luan T, Reddy S, Kuo AC

Acute Pain Is Associated With Chronic Opioid Use After Total Knee Arthroplasty.

Regional anesthesia and pain medicine

Hsia HL, Takemoto S, van de Ven T, Pyati S, Buchheit T, Ray N, Wellman S, Kuo A, Wallace A, Raghunathan K

American Joint Replacement Registry Risk Calculator Does Not Predict 90-day Mortality in Veterans Undergoing Total Joint Replacement.

Clinical orthopaedics and related research

Harris AHS, Kuo AC, Bozic KJ, Lau E, Bowe T, Gupta S, Giori NJ

The Effects of Topical Vancomycin on Mesenchymal Stem Cells: More May Not Be Better.

International journal of spine surgery

Chu S, Chen N, Dang ABC, Kuo AC, Dang ABC

Promoting Endochondral Bone Repair Using Human Osteoarthritic Articular Chondrocytes.

Tissue engineering. Part A

Bahney CS, Jacobs L, Tamai R, Hu D, Luan TF, Wang M, Reddy S, Park M, Limburg S, Kim HT, Marcucio R, Kuo AC

Complications of Morbid Obesity in Total Joint Arthroplasty: Risk Stratification Based on BMI.

The Journal of arthroplasty

Ward DT, Metz LN, Horst PK, Kim HT, Kuo AC

Trophic stimulation of articular chondrocytes by late-passage mesenchymal stem cells in coculture.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Wang M, Rahnama R, Cheng T, Grotkopp E, Jacobs L, Limburg S, Kim HT, Kuo AC

Mid-term outcomes in HIV-positive patients after primary total hip or knee arthroplasty.

The Journal of arthroplasty

Lin CA, Takemoto S, Kandemir U, Kuo AC

Peripheral nerve repair in rats using composite hydrogel-filled aligned nanofiber conduits with incorporated nerve growth factor.

Tissue engineering. Part A

Jin J, Limburg S, Joshi SK, Landman R, Park M, Zhang Q, Kim HT, Kuo AC

Comorbidities and perioperative complications in HIV-positive patients undergoing primary total hip and knee arthroplasty.

The Journal of bone and joint surgery. American volume

Lin CA, Kuo AC, Takemoto S

Cytotoxicity of local anesthetics on human mesenchymal stem cells.

The Journal of bone and joint surgery. American volume

Rahnama R, Wang M, Dang AC, Kim HT, Kuo AC

Functional motor recovery after peripheral nerve repair with an aligned nanofiber tubular conduit in a rat model.

Regenerative medicine

Jin J, Park M, Rengarajan A, Zhang Q, Limburg S, Joshi SK, Patel S, Kim HT, Kuo AC

Fibroblast growth factor 2 enhances the kinetics of mesenchymal stem cell chondrogenesis.

Biochemical and biophysical research communications

Cheng T, Yang C, Weber N, Kim HT, Kuo AC

Inducible immortality in hTERT-human mesenchymal stem cells.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Piper SL, Wang M, Yamamoto A, Malek F, Luu A, Kuo AC, Kim HT

Comparison of gene expression patterns in articular cartilage and dedifferentiated articular chondrocytes.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Cheng T, Maddox NC, Wong AW, Rahnama R, Kuo AC

Structured three-dimensional co-culture of mesenchymal stem cells with chondrocytes promotes chondrogenic differentiation without hypertrophy.

Osteoarthritis and Cartilage

Cooke ME, Allon AA, Cheng T, Kuo AC, Kim HT, Vail TP, Marcucio RS, Schneider RA, Lotz JC, Alliston T

In situ Materials Characterization using the Tissue Diagnostic Instrument.

Polymer testing

Tang SY, Mathews P, Randall C, Yurtsev E, Fields K, Wong A, Kuo A, Alliston T, Hansma P

The tissue diagnostic instrument.

The Review of scientific instruments

Hansma P, Yu H, Schultz D, Rodriguez A, Yurtsev EA, Orr J, Tang S, Miller J, Wallace J, Zok F, Li C, Souza R, Proctor A, Brimer D, Nogues-Solan X, Mellbovsky L, Peña MJ, Diez-Ferrer O, Mathews P, Randall C, Kuo A, Chen C, Peters M, Kohn D, Buckley J, Li X, Pruitt L, Diez-Perez A, Alliston T, Weaver V, Lotz J

Total hip arthroplasty in rapidly destructive osteoarthritis of the hip: a case series.

HSS journal : the musculoskeletal journal of Hospital for Special Surgery

Kuo A, Ezzet KA, Patil S, Colwell CW

Microfracture and bone morphogenetic protein 7 (BMP-7) synergistically stimulate articular cartilage repair.

Osteoarthritis and Cartilage

Kuo AC, Rodrigo JJ, Reddi AH, Curtiss S, Grotkopp E, Chiu M

Knee fusion using dual platings with the locking compression plate.

The Journal of arthroplasty

Kuo AC, Meehan JP, Lee M

Association of the transmembrane TGF-alpha precursor with a protein kinase complex.

The Journal of cell biology

Shum L, Reeves SA, Kuo AC, Fromer ES, Derynck R

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