Jonathan Graf, MD

Professor
Medicine
[email protected]
+1 628 206-8189

Graf is interested in translational research, moving laboratory discoveries into the clinic to help patients. He directs the UCSF Rheumatoid Arthritis (RA) Observational Cohort, which has enrolled more than 830 patients at UCSF and ZSFG. The cohort collects clinical information and blood samples from participants, making this information available to researchers at UCSF and beyond and jump-starting investigations that seek to improve treatment of patients with RA.

His own research focuses on cardiovascular risk in RA patients. "The inflammatory response is great if you’re bitten by a tiger, but becomes maladaptive if it persists beyond an acute crisis," said Graf. RA patients have chronic inflammation, which damages the body, including the lining of blood vessels – which is linked to increased risk of heart attack and stroke. Even RA patients whose joint swelling is well controlled appear to be at increased risk. He and his colleagues are testing whether offering advanced therapies to patients currently on standard medications leads to improved blood vessel function.

Interests: Rheumatoid arthritis, cardiovascular risk, diagnostic and prognostic biomarkers, immunology, auto-immunity 

Publications

A phase 2 trial of hydroxychloroquine in individuals at risk for rheumatoid arthritis.

Arthritis & rheumatology (Hoboken, N.J.)

Deane KD, Striebich CC, Feser ML, O'Dell JR, James JA, Sparks JA, Davis JM, Graf J, McMahon MA, Solow EB, Forbess L, Tiliakos A, Schiopu E, Danila MI, Horowitz DL, Kay J, Strickland CD, Guthridge JM, Arriens C, Grossman JM, Demoruelle MK, Bemis EA, Frazer-Abel A, Fleischer CL, Fox DA, Mikuls TR, Greenleaf M, York K, Walker S, Keyes-Elstein L, Byron M, Fedler J, Goldmuntz EA, Holers VM

Glucocorticoids and B Cell Depleting Agents Substantially Impair Immunogenicity of mRNA Vaccines to SARS-CoV-2.

medRxiv : the preprint server for health sciences

Deepak P, Kim W, Paley MA, Yang M, Carvidi AB, El-Qunni AA, Haile A, Huang K, Kinnett B, Liebeskind MJ, Liu Z, McMorrow LE, Paez D, Perantie DC, Schriefer RE, Sides SE, Thapa M, Gergely M, Abushamma S, Klebert M, Mitchell L, Nix D, Graf J, Taylor KE, Chahin S, Ciorba MA, Katz P, Matloubian M, O'Halloran JA, Presti RM, Wu GF, Whelan SPJ, Buchser WJ, Gensler LS, Nakamura MC, Ellebedy AH, Kim AHJ

Custom Person Type
Biology and Bio-Engineering