Duygu Tosun-Turgut, PhD

Associate Professor
Radiology & Biomedical Imaging
+1 415 221-4810 ext. 23650

Duygu Tosun-Turgut, PhD, is an Associate Professor and Co-Director of the Center for Imaging of Neurodegenerative Diseases (CIND) at the San Francisco Veterans Affairs Medical Center. Dr. Tosun obtained her BSc in Electrical and Electronic Engineering from Bilkent University, Turkey in 1999, and she received her MSE in Electrical and Computer Engineering from The Johns Hopkins University, Maryland in 2001. In 2003, she completed her MA in Mathematics from The Johns Hopkins University, and she earned her PhD in Electrical and Computer Engineering from The Johns Hopkins University in 2005, followed by a postdoctoral fellowship in Neurology from the University of California, Los Angeles in 2008.

Dr. Tosun’s long-term research goal is to develop new algorithmic approaches for processing and analysis of multi-disciplinary/modality data including neuroimages, genetics, proteomics, as well as cognitive functioning measures in a unified framework by using recent advances in image processing, medical physics, and computation medicine. The primary aim is to identify multi-disciplinary/modality biomarkers for detecting the changes associated with disease specific neuropathology, improving understanding of pathophysiological progression and potentially providing a means of monitoring the efficacy and regional specificity of drug therapy for neurodegenerative diseases. This will have a broad use in early diagnosis, facilitating initiation of prevention strategies in those at risk, and boost the power of drug therapy trials by selecting those at greatest risk of neurodegenerative diseases.

Dr. Tosun is a reviewer for 17 scientific journals. She has 29 published articles and she has written 30 peer-reviewed articles, 50 abstracts, and 5 significant publications.

Interests: neuroimaging, frailty, aging, neurodegenerative diseases, dementia, multimodality, MRI, PET, computational medicine, imaging biomarkers, neuropathology

Publications

APOE, ABCA7, and RASGEF1C are associated with earlier onset of amyloid deposition from more than 4000 harmonized positron emission tomography images.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Castellano T, Wang TC, Nolan E, Wu Y, Zhang M, Clifton M, Janve VA, Durant A, Regelson A, Cody K, Harrison T, Engelman CD, Jagust W, Albert M, Johnson S, Resnick SM, Sperling R, Bilgel M, Saykin A, Vardarajan B, Mayeux R, Alzheimer's Disease Neuroimaging Initiative, Betthauser T, Bennett DA, Schneider J, De Jager P, Menon V, Tosun D, Mormino E, Archer DB, Dumitrescu L, Hohman TJ, Koran ME

Hippocampal Atrophy on Magnetic Resonance Imaging as a Surrogate Marker for Clinical Benefit and Neurodegeneration in Early Symptomatic Alzheimer's Disease: Synthesis of Evidence from Observational and Interventional Trials.

CNS drugs

Abushakra S, Doraiswamy PM, Hey JA, Tosun D, Barkhof F, Barakos J, Petrella J, Kesslak JP, Power A, Sabbagh M, Porsteinsson A, Cohen S, Gauthier S, Ritchie C, Watson D, McSweeney E, Boada M, Liang E, Bracoud L, McLaine R, Flint S, Schaefer JF, Yu J, Bray M, Hendrix S, Dickson S, Durrant A, Albayrak A, Tolar M

Neuroanatomical dimensions in major depression linked to cognition, adverse life events, self-harm, metabolomics and genetics.

Communications medicine

Xiao W, Woodham RD, Cui Y, Wen J, Antoniades M, Srinivasan D, Fan Y, Erus G, Garcia JA, Arnott SR, Chen T, Choi KS, Chin Fatt C, Frey BN, Frokjaer VG, Ganz M, Godlewska BR, Hassel S, Ho K, McIntosh AM, Qin K, Rotzinger S, Sacchet MD, Savitz J, Shou H, Singh A, Stolicyn A, Strigo I, Strother SC, Tosun D, Wei D, Anderson IM, Craighead WE, Deakin JFW, Dunlop BW, Elliott R, Gong Q, Gotlib IH, Harmer CJ, Kennedy SH, Knudsen GM, Mayberg HS, Paulus MP, Qiu J, Trivedi MH, Whalley HC, Yan CG, Young AH, Davatzikos C, Fu CHY

Global network and local vulnerabilities underlie brain atrophy across Parkinson's disease stages.

Brain : a journal of neurology

Vo A, Tremblay C, Rahayel S, Al-Bachari S, Berendse HW, Bright JK, Cendes F, d'Angremont E, Dalrymple-Alford JC, Debove I, Dirkx MF, Druzgal J, Garraux G, Helmich RC, Hu MT, Jahanshad N, Johansson ME, Klein JC, Laansma MA, McMillan CT, Melzer TR, Misic B, Mosley P, Owens-Walton C, Parkes LM, Pellicano C, Piras F, Poston KL, Rango M, Rummel C, Schwingenschuh P, Suette M, Thompson PM, Tosun D, Tsai CC, van Balkom TD, van den Heuvel OA, van der Werf YD, van Heese EM, Vriend C, Wang JJ, Wiest R, Yasuda CL, Dagher A

Response to "Brain Amyloid and Cognitive Decline in Late-Life Depression".

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Rhodes E, Insel PS, Kassel M, Kryza-Lacombe M, Butters MA, Bickford D, Tosun D, Morin R, Aisen P, Rosen H, Raman R, Landau S, Saykin A, Toga AW, Jack CR, Weiner MW, Nelson C, Mackin RS

DRIPS: Domain Randomisation for Image-based Perivascular spaces Segmentation.

medRxiv : the preprint server for health sciences

Bitar L, Díaz M, Coello RD, Valdés-Hernández MDC, Mattern H, Neumann K, Pfister M, Beck C, Mai HT, Fuchs E, Tang S, Tosun D, Besteher B, Rocktäschel T, Reuken PA, Stallmach A, Opel N, Gaser C, Walter M, Dörner M, Arndt P, Behme D, Piechowiak C, Lading Y, Müller P, Braun-Dullaeus R, Meuth SG, Wardlaw JM, Schreiber S, Trujillo M, Düzel E, Ziegler G, Bernal J

Revisiting Centiloids using AI.

Research square

Bourgeat P, Fripp J, Lebrat L, Xia Y, Feizpour A, Cox T, Zisis G, Gillman A, Goyal M, Tosun D, Benzinger T, LaMontagne P, Breakspear M, Lupton M, Short C, Adam R, Robertson J, Sperling R, O'Bryant S, Johnson S, Jack C, Schwarz C, Park DC, Barkhof F, Farrar G, Bollack A, Collij L, Landau S, Koeppe R, Morris J, Weiner M, Villemagne V, Masters C, Rowe C, Doré V

Timing of Changes in Alzheimer's Disease Plasma Biomarkers as Assessed by Amyloid and Tau PET Clocks.

Annals of neurology

Milà-Alomà M, Tosun D, Schindler SE, Hausle I, Petersen KK, Li Y, Dage JL, Du-Cuny L, Saad ZS, Saef B, Triana-Baltzer G, Raunig DL, Coomaraswamy J, Baratta M, Meyers EA, Mordashova Y, Rubel CE, Ferber K, Kolb H, Ashton NJ, Zetterberg H, Rosenbaugh EG, Sabandal M, Shaw LM, Bannon AW, Potter WZ, Alzheimer's Disease Neuroimaging Initiative (ADNI), Foundation for the National Institutes of Health (FNIH) Biomarkers Consortium Plasma Aß and Phosphor

White Matter Abnormalities and Cognition in Aging and Alzheimer Disease.

JAMA neurology

Peter C, Sathe A, Shashikumar N, Pechman KR, Workmeister AW, Jackson TB, Huo Y, Mukherjee S, Mez J, Dumitrescu LC, Gifford KA, Bolton CJ, Gaynor LS, Risacher SL, Beason-Held LL, An Y, Arfanakis K, Erus G, Davatzikos C, Tosun-Turgut D, Habes M, Wang D, Toga AW, Thompson PM, Zhang P, Schilling KG, Albert M, Kukull W, Biber SA, Landman BA, Bendlin BB, Johnson SC, Schneider J, Barnes LL, Bennett DA, Jefferson AL, Resnick SM, Saykin AJ, Crane PK, Cuccaro ML, Hohman TJ, Archer DB, and the Alzheimer’s Disease Sequencing Project Phenotype Harmonization Consortium (ADSP-PHC) Analyst, Zaras D, Yang Y, Durant A, Kanakaraj P, Kim ME, Gao C, Newlin NR, Ramadass K, Khairi NM, Li Z, Yao T, Choi SE, Klinedinst B, Lee ML, Scollard P, Trittschuh EH, Sanders EA

Convergent large-scale network and local vulnerabilities underlie brain atrophy across Parkinson's disease stages: a worldwide ENIGMA study.

medRxiv : the preprint server for health sciences

Vo A, Tremblay C, Rahayel S, Al-Bachari S, Berendse HW, Bright JK, Cendes F, d'Angremont E, Dalrymple-Alford JC, Debove I, Dirkx MF, Druzgal J, Garraux G, Helmich RC, Hu M, Jahanshad N, Johansson ME, Klein JC, Laansma MA, McMillan CT, Melzer TR, Misic B, Mosley P, Owens-Walton C, Parkes LM, Pellicano C, Piras F, Poston KL, Rango M, Rummel C, Schwingenschuh P, Suette M, Thompson PM, Tosun D, Tsai CC, van Balkom TD, van den Heuvel OA, van der Werf YD, van Heese EM, Vriend C, Wang JJ, Wiest R, Yasuda C, Dagher A, ENIGMA-Parkinson’s Study

Genetic architecture of the limbic white matter microstructure in aging and Alzheimer's Disease.

medRxiv : the preprint server for health sciences

Lorenz A, Sathe A, Yang Y, Durant A, Wu Y, Kim ME, Gao C, Newlin NR, Ramadass K, Kanakaraj P, Khairi NM, Li Z, Yao T, Huo Y, Dumitrescu L, Shashikumar N, Pechman KR, Risacher SL, Beason-Held LL, An Y, Arfanakis K, Erus G, Davatzikos C, Habes M, Wang D, Tosun D, Toga AW, Thompson PM, Mormino EC, Zhang P, Schilling K, Alzheimer’s Disease Neuroimaging Initiative (ADNI), BIOCARD Study Team, Alzheimer’s Disease Sequencing Project (ADSP), Albert M, Kukull W, Biber SA, Landman BA, Johnson SC, Bendlin B, Schneider J, Bennett DA, Jefferson AL, Resnick SM, Saykin AJ, Hohman TJ, Archer DB

Neuroimaging-based data-driven subtypes of spatiotemporal atrophy due to Parkinson's disease.

Brain communications

Shawa Z, Shand C, Taylor B, Berendse HW, Vriend C, van Balkom TD, van den Heuvel OA, van der Werf YD, Wang JJ, Tsai CC, Druzgal J, Newman BT, Melzer TR, Pitcher TL, Dalrymple-Alford JC, Anderson TJ, Garraux G, Rango M, Schwingenschuh P, Suette M, Parkes LM, Al-Bachari S, Klein J, Hu MTM, McMillan CT, Piras F, Vecchio D, Pellicano C, Zhang C, Poston KL, Ghasemi E, Cendes F, Yasuda CL, Tosun D, Mosley P, Thompson PM, Jahanshad N, Owens-Walton C, d'Angremont E, van Heese EM, Laansma MA, Altmann A, ENIGMA Parkinson’s Disease Working Group , Weil RS, Oxtoby NP

The effect of Alzheimer's disease genetic factors on limbic white matter microstructure.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Lorenz A, Sathe A, Zaras D, Yang Y, Durant A, Kim ME, Gao C, Newlin NR, Ramadass K, Kanakaraj P, Khairi NM, Li Z, Yao T, Huo Y, Dumitrescu L, Shashikumar N, Pechman KR, Jackson TB, Workmeister AW, Risacher SL, Beason-Held LL, An Y, Arfanakis K, Erus G, Davatzikos C, Habes M, Wang D, Tosun D, Toga AW, Thompson PM, Mormino EC, Zhang P, Schilling K, Alzheimer's Disease Neuroimaging Initiative (ADNI)The BIOCARD Study TeamThe Alzheimer's Disease Sequ, Albert M, Kukull W, Biber SA, Landman BA, Johnson SC, Bendlin B, Schneider J, Barnes LL, Bennett DA, Jefferson AL, Resnick SM, Saykin AJ, Hohman TJ, Archer DB

Amyloid PET predicts longitudinal functional and cognitive trajectories in a heterogeneous cohort.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Younes K, Johns E, Young CB, Kennedy G, Mukherjee S, Vossler HA, Winer J, Cody K, Henderson VW, Poston KL, Betthauser TJ, Bevis B, Brooks WM, Burns JM, Coombes SA, DeCarli C, DiFilippo FP, Duara R, Fan AP, Gibbons LE, Golde T, Johnson SC, Lepping RJ, Leverenz J, McDougall S, Rogalski E, Sanders E, Pasaye J, Sridhar J, Saykin AJ, Sridharan A, Swerdlow R, Trittschuh EH, Vaillancourt D, Vidoni E, Wang WE, Mez J, Hohman TJ, Tosun D, Biber S, Kukull WA, Crane PK, Mormino EC

Overview of Alzheimer's Disease Neuroimaging Initiative and future clinical trials.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Weiner MW, Kanoria S, Miller MJ, Aisen PS, Beckett LA, Conti C, Diaz A, Flenniken D, Green RC, Harvey DJ, Jack CR, Jagust W, Lee EB, Morris JC, Nho K, Nosheny R, Okonkwo OC, Perrin RJ, Petersen RC, Rivera-Mindt M, Saykin AJ, Shaw LM, Toga AW, Tosun D, Veitch DP, Alzheimer's Disease Neuroimaging Initiative

Sex and APOE ε4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Peterson A, Sathe A, Zaras D, Yang Y, Durant A, Deters KD, Shashikumar N, Pechman KR, Kim ME, Gao C, Mohd Khairi N, Li Z, Yao T, Huo Y, Dumitrescu L, Gifford KA, Wilson JE, Cambronero FE, Risacher SL, Beason-Held LL, An Y, Arfanakis K, Erus G, Davatzikos C, Tosun D, Toga AW, Thompson PM, Mormino EC, Habes M, Wang D, Zhang P, Schilling K, Alzheimer's Disease Neuroimaging Initiative (ADNI), BIOCARD Study Team, Alzheimer's Disease Sequencing Project (ADSP), Albert M, Kukull W, Biber SA, Landman BA, Johnson SC, Schneider J, Barnes LL, Bennett DA, Jefferson AL, Resnick SM, Saykin AJ, Hohman TJ, Archer DB

Timing of changes in Alzheimer's disease plasma biomarkers as assessed by amyloid and tau PET clocks.

medRxiv : the preprint server for health sciences

Milà-Alomà M, Tosun D, Schindler SE, Hausle Z, Li Y, Petersen KK, Dage JL, Du-Cuny L, Saad ZS, Saef B, Triana-Baltzer G, Raunig DL, Coomaraswamy J, Baratta M, Meyers EA, Mordashova Y, Rubel CE, Ferber K, Kolb H, Ashton NJ, Zetterberg H, Rosenbaugh EG, Sabandal M, Shaw LM, Bannon AW, Potter WZ, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Foundation for the National Institutes of Health (FNIH) Biomarkers Consortium Plasma Aß and Phosphor

Relationship between MRI brain-age heterogeneity, cognition, genetics and Alzheimer's disease neuropathology.

EBioMedicine

Antoniades M, Srinivasan D, Wen J, Erus G, Abdulkadir A, Mamourian E, Melhem R, Hwang G, Cui Y, Govindarajan ST, Chen AA, Zhou Z, Yang Z, Chen J, Pomponio R, Sotardi S, An Y, Bilgel M, LaMontagne P, Singh A, Benzinger T, Beason-Held L, Marcus DS, Yaffe K, Launer L, Morris JC, Tosun D, Ferrucci L, Bryan RN, Resnick SM, Habes M, Wolk D, Fan Y, Nasrallah IM, Shou H, Davatzikos C

Head-to-head comparison of leading blood tests for Alzheimer's disease pathology.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Schindler SE, Petersen KK, Saef B, Tosun D, Shaw LM, Zetterberg H, Dage JL, Ferber K, Triana-Baltzer G, Du-Cuny L, Li Y, Coomaraswamy J, Baratta M, Mordashova Y, Saad ZS, Raunig DL, Ashton NJ, Meyers EA, Rubel CE, Rosenbaugh EG, Bannon AW, Potter WZ, Alzheimer's Disease Neuroimaging Initiative (ADNI) Foundation for the National Institutes of Health

Implementation and validation of face de-identification (de-facing) in ADNI4.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Schwarz CG, Choe M, Rossi S, Das SR, Ittyerah R, Fletcher E, Maillard P, Singh B, Harvey DJ, Malone IB, Prosser L, Senjem ML, Matoush LC, Ward CP, Prakaashana CM, Landau SM, Koeppe RA, Lee J, DeCarli C, Weiner MW, Jack CR, Jagust WJ, Yushkevich PA, Tosun D, Alzheimer's Disease Neuroimaging Initiative

Genetic and clinical correlates of two neuroanatomical AI dimensions in the Alzheimer's disease continuum.

Translational psychiatry

Wen J, Yang Z, Nasrallah IM, Cui Y, Erus G, Srinivasan D, Abdulkadir A, Mamourian E, Hwang G, Singh A, Bergman M, Bao J, Varol E, Zhou Z, Boquet-Pujadas A, Chen J, Toga AW, Saykin AJ, Hohman TJ, Thompson PM, Villeneuve S, Gollub R, Sotiras A, Wittfeld K, Grabe HJ, Tosun D, Bilgel M, An Y, Marcus DS, LaMontagne P, Benzinger TL, Heckbert SR, Austin TR, Launer LJ, Espeland M, Masters CL, Maruff P, Fripp J, Johnson SC, Morris JC, Albert MS, Bryan RN, Resnick SM, Ferrucci L, Fan Y, Habes M, Wolk D, Shen L, Shou H, Davatzikos C

Overview of ADNI MRI.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Jack CR, Arani A, Borowski BJ, Cash DM, Crawford K, Das SR, DeCarli C, Fletcher E, Fox NC, Gunter JL, Ittyerah R, Harvey DJ, Jahanshad N, Maillard P, Malone IB, Nir TM, Reid RI, Reyes DA, Schwarz CG, Senjem ML, Thomas DL, Thompson PM, Tosun D, Yushkevich PA, Ward CP, Weiner MW, Alzheimer's Disease Neuroimaging Initiative

Brain aging patterns in a large and diverse cohort of 49,482 individuals.

Nature medicine

Yang Z, Wen J, Erus G, Govindarajan ST, Melhem R, Mamourian E, Cui Y, Srinivasan D, Abdulkadir A, Parmpi P, Wittfeld K, Grabe HJ, Bülow R, Frenzel S, Tosun D, Bilgel M, An Y, Yi D, Marcus DS, LaMontagne P, Benzinger TLS, Heckbert SR, Austin TR, Waldstein SR, Evans MK, Zonderman AB, Launer LJ, Sotiras A, Espeland MA, Masters CL, Maruff P, Fripp J, Toga AW, O'Bryant S, Chakravarty MM, Villeneuve S, Johnson SC, Morris JC, Albert MS, Yaffe K, Völzke H, Ferrucci L, Nick Bryan R, Shinohara RT, Fan Y, Habes M, Lalousis PA, Koutsouleris N, Wolk DA, Resnick SM, Shou H, Nasrallah IM, Davatzikos C

A worldwide study of white matter microstructural alterations in people living with Parkinson's disease.

NPJ Parkinson's disease

Owens-Walton C, Nir TM, Al-Bachari S, Ambrogi S, Anderson TJ, Aventurato ÍK, Cendes F, Chen YL, Ciullo V, Cook P, Dalrymple-Alford JC, Dirkx MF, Druzgal J, Emsley HCA, Guimarães R, Haroon HA, Helmich RC, Hu MT, Johansson ME, Kim HB, Klein JC, Laansma M, Lawrence KE, Lochner C, Mackay C, McMillan CT, Melzer TR, Nabulsi L, Newman B, Opriessnig P, Parkes LM, Pellicano C, Piras F, Piras F, Pirpamer L, Pitcher TL, Poston KL, Roos A, Silva LS, Schmidt R, Schwingenschuh P, Shahid-Besanti M, Spalletta G, Stein DJ, Thomopoulos SI, Tosun D, Tsai CC, van den Heuvel OA, van Heese E, Vecchio D, Villalón-Reina JE, Vriend C, Wang JJ, Wu YR, Yasuda CL, Thompson PM, Jahanshad N, van der Werf Y

Design and validation of the ADNI MR protocol.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Arani A, Borowski B, Felmlee J, Reid RI, Thomas DL, Gunter JL, Stables L, Buckner RL, Jung Y, Tosun D, Weiner M, Jack CR, Alzheimer's Disease Neuroimaging Initiative

Evolution of white matter hyperintensity segmentation methods and implementation over the past two decades; an incomplete shift towards deep learning.

Brain imaging and behavior

Rahmani M, Dierker D, Yaeger L, Saykin A, Luckett PH, Vlassenko AG, Owens C, Jafri H, Womack K, Fripp J, Xia Y, Tosun D, Benzinger TLS, Masters CL, Lee JM, Morris JC, Goyal MS, Strain JF, ADOPIC, ADNI Investigators, Kukull W, Weiner M, Biostats, Database and Bioinformatics, Burnham S, CoxDoecke TJ, Fedyashov V, Fripp J, Shishegar R, Xiong C, Marcus D, Raniga P, Li S, Cognition, Aschenbrenner A, Hassenstab J, Lim YY, Maruff P, Sohrabi H, Robertson J, Markovic S, Imaging, Bourgeat P, Doré V, Mayo CJ, Mussoumzadeh P, Rowe C, Villemagne V, CSF and Blood, Bateman R, Fowler C, Li QX, Martins R, Schindler S, Shaw L, Genetics, Cruchaga C, Harari O, Laws S, Porter T, O'Brien E, Neuropathology, Perrin R, NACC, Kukull W, DIAN, Bateman R, McDade E, Cerebrovascular Disease (CVD) Risk, Jack C, Morris J, Yassi N, Hippocampal Sclerosis (HS-TDP43) Risk, Bourgeat P, Perrin R, Roberts B, Villemagne V, Artificial Intelligence and Machine Learning, Fedyashov V, Goudey B

Sex, racial, and APOE-ε4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer's disease.

bioRxiv : the preprint server for biology

Peterson A, Sathe A, Zaras D, Yang Y, Durant A, Deters KD, Shashikumar N, Pechman KR, Kim ME, Gao C, Khairi NM, Li Z, Yao T, Huo Y, Dumitrescu L, Gifford KA, Wilson JE, Cambronero F, Risacher SL, Beason-Held LL, An Y, Arfanakis K, Erus G, Davatzikos C, Tosun D, Toga AW, Thompson PM, Mormino EC, Zhang P, Schilling K, Alzheimer’s Disease Neuroimaging Initiative (ADNI), BIOCARD Study Team, Alzheimer’s Disease Sequencing Project (ADSP), Albert M, Kukull W, Biber SA, Landman BA, Johnson SC, Schneider J, Barnes LL, Bennett DA, Jefferson AL, Resnick SM, Saykin AJ, Hohman TJ, Archer DB

Genetic and Clinical Correlates of AI-Based Brain Aging Patterns in Cognitively Unimpaired Individuals.

JAMA psychiatry

Skampardoni I, Nasrallah IM, Abdulkadir A, Wen J, Melhem R, Mamourian E, Erus G, Doshi J, Singh A, Yang Z, Cui Y, Hwang G, Ren Z, Pomponio R, Srinivasan D, Govindarajan ST, Parmpi P, Wittfeld K, Grabe HJ, Bülow R, Frenzel S, Tosun D, Bilgel M, An Y, Marcus DS, LaMontagne P, Heckbert SR, Austin TR, Launer LJ, Sotiras A, Espeland MA, Masters CL, Maruff P, Fripp J, Johnson SC, Morris JC, Albert MS, Bryan RN, Yaffe K, Völzke H, Ferrucci L, Benzinger TLS, Ezzati A, Shinohara RT, Fan Y, Resnick SM, Habes M, Wolk D, Shou H, Nikita K, Davatzikos C

Neuroanatomical dimensions in medication-free individuals with major depressive disorder and treatment response to SSRI antidepressant medications or placebo.

Nature. Mental health

Fu CHY, Antoniades M, Erus G, Garcia JA, Fan Y, Arnone D, Arnott SR, Chen T, Choi KS, Fatt CC, Frey BN, Frokjaer VG, Ganz M, Godlewska BR, Hassel S, Ho K, McIntosh AM, Qin K, Rotzinger S, Sacchet MD, Savitz J, Shou H, Singh A, Stolicyn A, Strigo I, Strother SC, Tosun D, Victor TA, Wei D, Wise T, Zahn R, Anderson IM, Craighead WE, Deakin JFW, Dunlop BW, Elliott R, Gong Q, Gotlib IH, Harmer CJ, Kennedy SH, Knudsen GM, Mayberg HS, Paulus MP, Qiu J, Trivedi MH, Whalley HC, Yan CG, Young AH, Davatzikos C

Five dominant dimensions of brain aging are identified via deep learning: associations with clinical, lifestyle, and genetic measures.

medRxiv : the preprint server for health sciences

Yang Z, Wen J, Erus G, Govindarajan ST, Melhem R, Mamourian E, Cui Y, Srinivasan D, Abdulkadir A, Parmpi P, Wittfeld K, Grabe HJ, Bülow R, Frenzel S, Tosun D, Bilgel M, An Y, Yi D, Marcus DS, LaMontagne P, Benzinger TLS, Heckbert SR, Austin TR, Waldstein SR, Evans MK, Zonderman AB, Launer LJ, Sotiras A, Espeland MA, Masters CL, Maruff P, Fripp J, Toga A, O'Bryant S, Chakravarty MM, Villeneuve S, Johnson SC, Morris JC, Albert MS, Yaffe K, Völzke H, Ferrucci L, Bryan NR, Shinohara RT, Fan Y, Habes M, Lalousis PA, Koutsouleris N, Wolk DA, Resnick SM, Shou H, Nasrallah IM, Davatzikos C

Genomic loci influence patterns of structural covariance in the human brain.

Proceedings of the National Academy of Sciences of the United States of America

Wen J, Nasrallah IM, Abdulkadir A, Satterthwaite TD, Yang Z, Erus G, Robert-Fitzgerald T, Singh A, Sotiras A, Boquet-Pujadas A, Mamourian E, Doshi J, Cui Y, Srinivasan D, Skampardoni I, Chen J, Hwang G, Bergman M, Bao J, Veturi Y, Zhou Z, Yang S, Dazzan P, Kahn RS, Schnack HG, Zanetti MV, Meisenzahl E, Busatto GF, Crespo-Facorro B, Pantelis C, Wood SJ, Zhuo C, Shinohara RT, Gur RC, Gur RE, Koutsouleris N, Wolf DH, Saykin AJ, Ritchie MD, Shen L, Thompson PM, Colliot O, Wittfeld K, Grabe HJ, Tosun D, Bilgel M, An Y, Marcus DS, LaMontagne P, Heckbert SR, Austin TR, Launer LJ, Espeland M, Masters CL, Maruff P, Fripp J, Johnson SC, Morris JC, Albert MS, Bryan RN, Resnick SM, Fan Y, Habes M, Wolk D, Shou H, Davatzikos C

Relationship of Hoarding and Depression Symptoms in Older Adults.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Nutley S, Nguyen BK, Mackin RS, Insel PS, Tosun D, Butters M, Aisen P, Raman R, Saykin AJ, Toga AW, Jack C, Weiner MW, Nelson C, Kassel M, Kryza-Lacombe M, Eichenbaum J, Nosheny RL, Mathews CA

A universal neocortical mask for Centiloid quantification.

Alzheimer's & dementia (Amsterdam, Netherlands)

Bourgeat P, Doré V, Rowe CC, Benzinger T, Tosun D, Goyal MS, LaMontagne P, Jin L, Weiner MW, Masters CL, Fripp J, Villemagne VL, Alzheimer's Disease Neuroimaging Initiative, OASIS3, and the AIBL research group

AI-based dimensional neuroimaging system for characterizing heterogeneity in brain structure and function in major depressive disorder: COORDINATE-MDD consortium design and rationale.

BMC psychiatry

Fu CHY, Erus G, Fan Y, Antoniades M, Arnone D, Arnott SR, Chen T, Choi KS, Fatt CC, Frey BN, Frokjaer VG, Ganz M, Garcia J, Godlewska BR, Hassel S, Ho K, McIntosh AM, Qin K, Rotzinger S, Sacchet MD, Savitz J, Shou H, Singh A, Stolicyn A, Strigo I, Strother SC, Tosun D, Victor TA, Wei D, Wise T, Woodham RD, Zahn R, Anderson IM, Deakin JFW, Dunlop BW, Elliott R, Gong Q, Gotlib IH, Harmer CJ, Kennedy SH, Knudsen GM, Mayberg HS, Paulus MP, Qiu J, Trivedi MH, Whalley HC, Yan CG, Young AH, Davatzikos C

Increasing participant diversity in AD research: Plans for digital screening, blood testing, and a community-engaged approach in the Alzheimer's Disease Neuroimaging Initiative 4.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Weiner MW, Veitch DP, Miller MJ, Aisen PS, Albala B, Beckett LA, Green RC, Harvey D, Jack CR, Jagust W, Landau SM, Morris JC, Nosheny R, Okonkwo OC, Perrin RJ, Petersen RC, Rivera-Mindt M, Saykin AJ, Shaw LM, Toga AW, Tosun D, Trojanowski JQ, Alzheimer's Disease Neuroimaging Initiative

ADAMANT: a placebo-controlled randomized phase 2 study of AADvac1, an active immunotherapy against pathological tau in Alzheimer's disease.

Nature aging

Novak P, Kovacech B, Katina S, Schmidt R, Scheltens P, Kontsekova E, Ropele S, Fialova L, Kramberger M, Paulenka-Ivanovova N, Smisek M, Hanes J, Stevens E, Kovac A, Sutovsky S, Parrak V, Koson P, Prcina M, Galba J, Cente M, Hromadka T, Filipcik P, Piestansky J, Samcova M, Prenn-Gologranc C, Sivak R, Froelich L, Fresser M, Rakusa M, Harrison J, Hort J, Otto M, Tosun D, Ondrus M, Winblad B, Novak M, Zilka N

Clinical and Dopamine Transporter Imaging Characteristics of Leucine Rich Repeat Kinase 2 (LRRK2) and Glucosylceramidase Beta (GBA) Parkinson's Disease Participants in the Parkinson's Progression Markers Initiative: A Cross-Sectional Study.

Movement disorders : official journal of the Movement Disorder Society

Simuni T, Brumm MC, Uribe L, Caspell-Garcia C, Coffey CS, Siderowf A, Alcalay RN, Trojanowski JQ, Shaw LM, Seibyl J, Singleton A, Toga AW, Galasko D, Foroud T, Nudelman K, Tosun-Turgut D, Poston K, Weintraub D, Mollenhauer B, Tanner CM, Kieburtz K, Chahine LM, Reimer A, Hutten S, Bressman S, Marek K, Parkinson's Progression Markers Initiative Investigators

Clinical and dopamine transporter imaging characteristics of non-manifest LRRK2 and GBA mutation carriers in the Parkinson's Progression Markers Initiative (PPMI): a cross-sectional study.

The Lancet. Neurology

Simuni T, Uribe L, Cho HR, Caspell-Garcia C, Coffey CS, Siderowf A, Trojanowski JQ, Shaw LM, Seibyl J, Singleton A, Toga AW, Galasko D, Foroud T, Tosun D, Poston K, Weintraub D, Mollenhauer B, Tanner CM, Kieburtz K, Chahine LM, Reimer A, Hutten SJ, Bressman S, Marek K, PPMI Investigators

Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases.

Brain : a journal of neurology

Betts MJ, Kirilina E, Otaduy MCG, Ivanov D, Acosta-Cabronero J, Callaghan MF, Lambert C, Cardenas-Blanco A, Pine K, Passamonti L, Loane C, Keuken MC, Trujillo P, Lüsebrink F, Mattern H, Liu KY, Priovoulos N, Fliessbach K, Dahl MJ, Maaß A, Madelung CF, Meder D, Ehrenberg AJ, Speck O, Weiskopf N, Dolan R, Inglis B, Tosun D, Morawski M, Zucca FA, Siebner HR, Mather M, Uludag K, Heinsen H, Poser BA, Howard R, Zecca L, Rowe JB, Grinberg LT, Jacobs HIL, Düzel E, Hämmerer D

Polygenic hazard score, amyloid deposition and Alzheimer's neurodegeneration.

Brain : a journal of neurology

Tan CH, Bonham LW, Fan CC, Mormino EC, Sugrue LP, Broce IJ, Hess CP, Yokoyama JS, Rabinovici GD, Miller BL, Yaffe K, Schellenberg GD, Kauppi K, Holland D, McEvoy LK, Kukull WA, Tosun D, Weiner MW, Sperling RA, Bennett DA, Hyman BT, Andreassen OA, Dale AM, Desikan RS, Alzheimer’s Disease Neuroimaging Initiative

The Parkinson's progression markers initiative (PPMI) - establishing a PD biomarker cohort.

Annals of clinical and translational neurology

Marek K, Chowdhury S, Siderowf A, Lasch S, Coffey CS, Caspell-Garcia C, Simuni T, Jennings D, Tanner CM, Trojanowski JQ, Shaw LM, Seibyl J, Schuff N, Singleton A, Kieburtz K, Toga AW, Mollenhauer B, Galasko D, Chahine LM, Weintraub D, Foroud T, Tosun-Turgut D, Poston K, Arnedo V, Frasier M, Sherer T, Parkinson's Progression Markers Initiative

Longitudinal Change of Clinical and Biological Measures in Early Parkinson's Disease: Parkinson's Progression Markers Initiative Cohort.

Movement disorders : official journal of the Movement Disorder Society

Simuni T, Siderowf A, Lasch S, Coffey CS, Caspell-Garcia C, Jennings D, Tanner CM, Trojanowski JQ, Shaw LM, Seibyl J, Schuff N, Singleton A, Kieburtz K, Toga AW, Mollenhauer B, Galasko D, Chahine LM, Weintraub D, Foroud T, Tosun D, Poston K, Arnedo V, Frasier M, Sherer T, Chowdhury S, Marek K, Parkinson's Progression Marker Initiative*